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FLASH GENE
Symbol CDHR2 contributors: npt/ - updated : 23-02-2006
HGNC name cadherin-related family member 2
HGNC id 18231
Location 5q35.2      Physical location : 175.969.511 - 176.022.769
Synonym name
  • protocadherin 24
  • protocadherin LKC
  • Synonym symbol(s) FLJ20124, FLJ20383, PCLKC, PCDH24, MGC163154
    DNA
    TYPE functioning gene
    STRUCTURE 46.41 kb     32 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    32 - 4127 141 1310 - -
    - - 4313 141 1310 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestine   
     liver    
     mouth    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide
  • nine cadherin repeat domains
  • a unique cytoplasmic region
  • HOMOLOGY
    interspecies ortholog to murine BC040758
    Homologene
    FAMILY
  • cadherin superfamily
  • protocadherin family
  • CATEGORY adhesion , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • putative molecular switch for contact inhibition of epithelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • PDZ protein
  • MAST2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in kidney, colon and liver cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS