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FLASH GENE
Symbol CDH17 contributors: - updated : 02-03-2007
HGNC name cadherin 17, LI cadherin (liver-intestine)
HGNC id 1756
Location 8q22.1      Physical location : 95.139.393 - 95.229.531
Synonym name liver-intestine cadherin
Synonym symbol(s) HPT1, CDH16, FLJ26931, HPT-1, MGC138218
DNA
TYPE functioning gene
STRUCTURE 81.00 kb     18 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
DKFZp762C1112 8q21.3 hypothetical protein DKFZp762C1112 EFCBP1 8q21.3 EF hand calcium binding protein 1 DKFZp762O076 8q21.3 hypothetical protein DKFZp762O076 CGI-77 8q21.3 CGI-77 protein LOC340451 SLC26A7 8q23 solute carrier family 26, member 7 MRPS16P1 8q21.3 solute carrier family 26, member 7 CBFA2T1 8q22 core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related LOC389675 8 similar to 40S ribosomal protein S26 LOC389676 8 LOC389676 LOC392251 8 similar to KIAA1588 protein LOC137392 8q22.1 similar to CG6405 gene product LOC389677 8 similar to RIKEN cDNA 3000004N20 PRO1905 8q22.1 hypothetical protein PRO1905 MGC26979 8q22.1 hypothetical protein MGC26979 LOC157667 8q22.1 similar to myosin regulatory light chain-like PPM2C 8q22.1 protein phosphatase 2C, magnesium-dependent, catalytic subunit CDH17 8q22.1 cadherin 17, LI cadherin (liver-intestine) GEM 8q22.3 GTP binding protein overexpressed in skeletal muscle LOC392252 8 similar to ribosomal protein S4, X-linked RAD54B 8q21.3-q22 similar to ribosomal protein S4, X-linked FSBP 8q22.1 fibrinogen silencer binding protein DKFZP434I116 8q22.1 DKFZP434I116 protein FLJ20171 8q22.1 hypothetical protein FLJ20171 LOC286148 8q22.1 hypothetical protein LOC286148 FLJ20530 8q22.1 hypothetical protein FLJ20530 CCNE2 8q22.1 cyclin E2 LOC392253 8 similar to Ac2-210 TP53INP1 8q22 tumor protein p53 inducible nuclear protein 1 MGC40214 8q22.1 hypothetical protein MGC40214 PLEKHF2 8q22.1 pleckstrin homology domain containing, family F (with FYVE domain) member 2 LOC157657 8q22.1 hypothetical protein LOC157657 LOC392254 8 similar to glyceraldehyde-3-phosphate dehydrogenase LOC392255 8 similar to growth and differentiation factor 6 UQCRB 8q22 ubiquinol-cytochrome c reductase binding protein CGI-12 8q22.1 CGI-12 protein PTDSS1 8q22 phosphatidylserine synthase 1 SDC2 8q22-q23 syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan) PGCP 8q22.2 plasma glutamate carboxypeptidase KIAA1750 8q22.1 KIAA1750 protein
regionally located . located in a region deleted (LOH) in adult acute leukemia
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
 intestinelarge intestinecolon  
 liver    
Nervousnervecranial nerve   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal hydrophobic domain
  • five extracellular cadherin repeats with four cysteines in the most proximal
  • a transmembrane segment and a highly conserved cytoplasmic tail required for interactions
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    basic FUNCTION
  • transmembrane glycoprotein component of adherens junctioninvolved in cell-cell or cell-ECM interactions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
  • hemophilic,calcium dependent interactions
  • interacting by itsC terminus with the cytoskeleton via beta-catenin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in colorectal carcinoma with a high tumor grade, lymphatic invasion, lymph node metastasis
    tumoral     --over  
    in liver cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS