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FLASH GENE
Symbol CDH16 contributors: mct - updated : 19-11-2013
HGNC name cadherin 16, KSP-cadherin
HGNC id 1755
Location 16q22.1      Physical location : 66.942.025 - 66.952.766
Synonym name
  • kidney-specific cadherin
  • Synonym symbol(s) PCADL1
    DNA
    TYPE like-sequence
    STRUCTURE 10.00 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • CDH16 minimal promoter is transcriptionally active in thyroid cells as well as in kidney cells
  • MAPPING cloned Y linked N status confirmed
    Map cen - D16S514 - D16S3019 - CDH16 - CDH1 - D16S496 - qter
    Authors Baudry (00)
    Physical map
    LOC390736 16 similar to Spermatogenesis associated protein 2 (Spermatogenesis associated protein PD1) TK2 16q22 thymidine kinase 2, mitochondrial FLJ20006 16q22.1 hypothetical protein FLJ20006 CKLF 16q22.1 chemokine-like factor CKLFSF1 16q22.1 chemokine-like factor super family 1 CKLFSF2 16q22.1 chemokine-like factor super family 2 CKLFSF3 16q22.1 chemokine-like factor super family 3 CKLFSF4 16q22.1 chemokine-like factor super family 4 DNCLI2 16q22.1 dynein, cytoplasmic, light intermediate polypeptide 2 FLJ35894 16q22.1 hypothetical protein FLJ35894 APPBP1 16q22 amyloid beta precursor protein binding protein 1, 59kDa CA7 16q22.1 carbonic anhydrase VII KIAA1348 CDH16 16q22.1 cadherin 16, KSP-cadherin RRAD 16q22 Ras-related associated with diabetes CGI-128 16q22.1-q22.3 CGI-128 protein CES2 16q22.1 carboxylesterase 2 (intestine, liver) FLJ21736 16q22.1 esterase 31 FLJ37464 16q22.1 hypothetical protein FLJ37464 CBFB 16q22.1 core-binding factor, beta subunit Lin10 16q22.1 lin-10 protein homolog MGC4655 16q22.1 hypothetical protein MGC4655 TRADD 16q22 TNFRSF1A-associated via death domain FBXL8 16q23.1 F-box and leucine-rich repeat protein 8 HSF4 16q21 heat shock transcription factor 4 NOL3 16qp21-q23 nucleolar protein 3 (apoptosis repressor with CARD domain) LOC283849 16q22.1 hypothetical protein LOC283849 E2F4 16q22.1 E2F transcription factor 4, p107/p130-binding ELMO3 16q23.1 engulfment and cell motility 3 (ced-12 homolog, C. elegans) FBXL9 16q23-q31 F-box and leucine-rich repeat protein 9 HSPC171 16q22.1 HSPC171 protein FHOD1 16q22 formin homology 2 domain containing 1 SLC9A5 16q22.1 solute carrier family 9 (sodium/hydrogen exchanger), isoform 5 DKFZP434I216 16q22.1 DKFZP434I216 protein FLJ40162 16q22.1 FLJ40162 protein FLJ11004 16q22.1 hypothetical protein FLJ11004
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid     Mus musculus
    Urinarykidney   specific SELECTED Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrinethyroid cell Mus musculus
    Urinaryepithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal hydrophobic domain
  • five extracellular cadherin repeats with four cysteines in the most proximal (MPED)
  • a transmembrane segment
  • a highly conserved cytoplasmic tail required for interactions
  • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to CDH17
    Homologene
    FAMILY cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    basic FUNCTION
  • transmembrane glycoprotein component of adherens junction
  • cell-cell or cell-ECM interactions
  • playing a role in tumour suppression
  • functional cell-cell adhesion molecule related to CDH17
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component transmembrane glycoprotein constituent of adherens junction
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • hemophilic,calcium dependent interactions
  • interacting by its C terminus with the cytoskeleton via beta-catenin
  • is a novel downstream target of the transcription factor PAX8, likely since the early steps of thyroid development, and its expression is associated with the fully differentiated state of the thyroid cell
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS