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FLASH GENE
Symbol CDH12 contributors: mct - updated : 26-03-2008
HGNC name cadherin 12, type 2 (N-cadherin 2)
HGNC id 1751
Location 5p14-p13      Physical location : 21.750.972 - 22.853.731
Synonym name
  • brain-cadherin; cadherin 12, type 2
  • cadherin, neural type, 2
  • cadherin-12
  • Synonym symbol(s) BCAD, CDHB, FLJ34857
    DNA
    TYPE functioning gene
    STRUCTURE 1098.00 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    LOC391763 5 similar to Transcription initiation factor TFIID 28 kDa subunit (TAFII-28) (TAFII28) (TFIID subunit p30-beta) LOC391764 5 similar to TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor LOC391765 5 similar to H3.3 like histone MH321 - mouse LOC391766 5 similar to Transcription initiation factor TFIID 28 kDa subunit (TAFII-28) (TAFII28) (TFIID subunit p30-beta) LOC391767 5 similar to Transcription initiation factor TFIID 28 kDa subunit (TAFII-28) (TAFII28) (TFIID subunit p30-beta) LOC391768 5 similar to TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor LOC391769 5 similar to histone (15.4 kD) (his-72) LOC391770 5 similar to ENSANGP00000014197 CDH18 5p15.2-p14.3 cadherin 18, type 2 LOC266786 5p14 nucleoporin 50 kDa pseudogene SMA4 5q13 SMA4 CDH12 5p14-p13 cadherin 12, type 2 (N-cadherin 2) PMCHL1 5p14 pro-melanin-concentrating hormone-like 1 LOC391771 5 similar to protein tyrosine phosphatase, non-receptor type 11; protein-tyrosine phosphatase 2C; Noonan syndrome 1 LOC389276 5 similar to CDNA sequence BC012016 PRDM9 5p14 PR domain containing 9 FLJ34836 5p14.2 hypothetical protein FLJ34836 LOC389277 5 hypothetical gene supported by NM_022476 CDH10 5p14-p13 cadherin 10, type 2 (T2-cadherin)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 4164 - 794 - Shimoyama (2000)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivemale systemtestis   
    Respiratoryrespiratory tracttrachea   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal hydrophobic domain
  • five extracellular cadherin repeats with four cysteines in the most proximal (MPED)
  • a transmembrane segment (1TM) and a highly conserved cytoplasmic tail required for interactions
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    basic FUNCTION
  • putatively involved in synaptic adhesion
  • axon outgrowth and guidance
  • cell-cell or cell-ECM interactions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component constituent of transmembrane glycoprotein component of adherens junction
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • hemophilic, calcium dependent interactions
  • interacting by its C terminus with the cytoskeleton via beta-catenin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS