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FLASH GENE
Symbol CDH10 contributors: mct/npt - updated : 15-09-2009
HGNC name cadherin 10, type 2 (T2-cadherin)
HGNC id 1749
Location 5p14.2      Physical location : 24.487.209 - 24.645.085
Synonym name
  • T2-cadherin
  • cadherin-10
  • DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    STRUCTURE 157.00 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 3261 - 788 - Gil (2002)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland    
    Nervousbrain   predominantly
    Reproductivefemale systemuteruscervix  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text lung
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal hydrophobic domain
  • five extracellular cadherin repeats with four cysteines in the most proximal (MPED)
  • a transmembrane segment
  • a highly conserved cytoplasmic tail required for interactions
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    basic FUNCTION
  • transmembrane glycoprotein, component of adherens junction, putatively involved in synaptic adhesions
  • cell-cell or cell-ECM interactions
  • putatively involved in synaptic adhesions, axon outgrowth and guidance
  • mediate calcium-dependent cell-cell adhesion
  • playing a specific role in secretory cell terminal differentiation, and in normal prostate organisation and function (Walker 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • homophilic, calcium dependent interactions
  • interacting by its C terminus with the cytoskeleton via beta-catenin
  • interact with catenins and function in cell-cell adhesion as do other classic cadherins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to autism spectrum disorder
    Variant & Polymorphism SNP rs4307059 increasing the risk of autism spectrum disorder (Wang 2009)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS