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FLASH GENE
Symbol CDCP1 contributors: mct - updated : 23-08-2012
HGNC name CUB domain containing protein 1
HGNC id 24357
Location 3p21.31      Physical location : 45.123.769 - 45.187.914
Synonym name transmembrane and associated with src kinases
Synonym symbol(s) CD318, TRASK, SIMA135, UNQ2486/PRO5773, gp140
DNA
TYPE functioning gene
STRUCTURE 64.15 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (CAAT box) (TATA box)
cytosine-phosphate-guanine/HTF
MAPPING cloned Y linked N status provisional
Physical map
FLJ36157 3p21.32 FLJ36157 protein DKFZp313N0621 3p21.32 hypothetical protein DKFZp313N0621 LOC285344 3p21.32 similar to hypothetical protein MG11009.4 ZNF445 3p21.32 zinc finger protein 445 LOC285346 3p21.32 hypothetical protein LOC285346 ZNF167 3p22-p21 zinc finger protein 167 LOC389115 3 hypothetical gene supported by BC009982; NM_015134 FLJ36870 3p21.32 hypothetical protein FLJ36870 ZNF197 3p21.2-p21.1 zinc finger protein 197 ZNF35 3p21 zinc finger protein 35 (clone HF.10) LOC391531 3 similar to zinc finger protein 347; zinc finger 1111 LOC389116 3 hypothetical gene supported by AL136896; NM_014011 ZNF502 3p21.32 zinc finger protein 502 ZNF501 3p21.32 zinc finger protein 501 KIAA1143 3p21.32 KIAA1143 protein KNSL7 3p21.33 kinesin-like 7 MGC29956 3p21.32 hypothetical protein MGC29956 LOC391532 3 similar to peptidyl-Pro cis trans isomerase TGM4 3p22-p21.3 transglutaminase 4 (prostate) FLJ20209 3p21.32 hypothetical protein FLJ20209 ZDHHC3 3p21.32 zinc finger, DHHC domain containing 3 KIAA0116 3p21 Homo sapiens KIAA0116 protein (KIAA0116), mRNA. TNA 3p21.3 tetranectin (plasminogen binding protein) CDCP1 3p24.3-p22.1 tetranectin (plasminogen binding protein) RIS1 3p21.3 tetranectin (plasminogen binding protein) LARS2 3p21.3 leucyl-tRNA synthetase 2, mitochondrial LIMD1 3p21.3 LIM domains containing 1 SACM1L 3p21.3 SAC1 suppressor of actin mutations 1-like (yeast) XT3 3p21.3 SAC1 suppressor of actin mutations 1-like (yeast) LZTFL1 3p21.3 leucine zipper transcription factor-like 1 CCR9 3p21.3 chemokine (C-C motif) receptor 9 FYCO1 3p21.3 FYVE and coiled-coil domain containing 1 CXCR6 3p21.3 chemokine (C-X-C motif) receptor 6
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 6017 92 836 - 2011 21220330
4 splicing 1410 37 343 - 2011 21220330
  • differs in the 3' UTR
  • has a distinct and shorter C-terminus
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     stomach    
    Reproductivemale systemprostate   
    Urinarybladder    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticprogenitor cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    three extracellular CUB domains
    HOMOLOGY
    interspecies ortholog to murine Cdcp1
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • likely involved in cell adhesion or interacting with the extracellular matrix
  • functions as an antiapoptotic molecule and indicate that during metastasis CDCP1 facilitates tumor cell survival likely during or soon after extravasation
  • regulates anoikis resistance as well as cancer cell migration and invasion
  • CDCP1 expression might play a crucial role in poor outcome of pancreatic cancer through promotion of invasion and metastasis
  • having functions to regulate cell adhesion
  • is not only a surface marker for cells with higher metastatic potential, but also functionally involved in enhancing tumor metastasis
  • key requirement for CDCP1-mediated activation of SRC (and perhaps other SFKs) in the functions of CDCP1 in altered cell–cell and cell–substratum adhesion and in metastasis
  • CDCP1 expression might play a crucial role in poor outcome of clear cell renal cell carcinoma patients through stimulation of migration and metastasis
  • hypoxia-inducible and VHL-regulated gene
  • plays a critical role in the process of metastasis and in the survival of cells at distant sites of metastasis
  • SRC-associated protein CDCP1 regulates adhesion and motility
  • CELLULAR PROCESS cell life
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • hypoxia activates a CDCP1-SRC signaling pathway that appears to play a critical role in migration under hypoxic conditions
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • modulates the enzymatic activity of PRKCD through the tyrosine phosphorylation of PRKCD by recruiting PRKCD to SRC family kinases
  • specifically regulates phosphorylation of PRKCD, but not of focal adhesion kinase or Crk-associated substrate
  • downstream target of HIFs and plays a critical role in kidney cancer migration
  • SRC substrate potentially involved in metastasis
  • is a key regulator of EGF/EGFR-induced cell migration
  • critical role for CDCP1 as a unique EPAS1 target gene involved in the regulation of cancer metastasis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colon and lung cancer
    tumoral     --over  
    in pancreatic cancer, significantly correlated with overall survival
    tumoral     --over  
    in highly metastatic melanomas
    tumoral     --over  
    can be correlated with low overall patient survival in kidney cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • biomarker for metastatic cancers, especially clear cell renal cell carcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerurinary 
    might serve as a therapeutic target for clear cell renal cell carcinoma
    cancerendocrinepancreas
    molecules blocking the expression, phosphorylation, or the PRKCD-binding site of CDCP1 are potential therapeutic candidates for pancreatic cancer
    cancerlung 
    novel target for treating cancer-specific disorders, such as metastasis, by regulating anoikis in lung adenocarcinoma
    cancer  
    targeting of CDCP1 may be a rational approach to inhibit progression of cancers driven by EGFR signaling including those resistant to anti-EGFR drugs because of activating mutations in the RAS/RAF/MEK/ERK pathway
    cancermetastases 
    potential therapeutic target for metastatic cancers
    ANIMAL & CELL MODELS