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FLASH GENE
Symbol CDCA7 contributors: mct - updated : 07-12-2017
HGNC name cell division cycle associated 7
HGNC id 14628
Corresponding disease
ICF3 immunodeficiency, centromeric instability, and facial anomalies syndrome 3
Location 2q31.1      Physical location : 174.219.560 - 174.233.718
Synonym name
  • c-Myc target JPO1
  • cell division cycle associated protein 7 isoform 2 variant
  • Synonym symbol(s) JPO1, FLJ14722, FLJ14736, MGC34109
    DNA
    TYPE functioning gene
    STRUCTURE 14.97 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391460 2 similar to 60S ribosomal protein L21 DNCI2 2q24-q31 dynein, cytoplasmic, intermediate polypeptide 2 SLC25A12 2q24-q31 solute carrier family 25 (mitochondrial carrier, Aralar), member 12 HAT1 2q31.2-q33.1 histone acetyltransferase 1 MAP1D 2q31.1 methionine aminopeptidase 1D DLX1 2q32 distal-less homeo box 1 DLX2 2q32 distal-less homeo box 2 ITGA6 2q22-q31 integrin, alpha 6 PDK1 2q31.1 pyruvate dehydrogenase kinase, isoenzyme 1 CGEF2 2q31 pyruvate dehydrogenase kinase, isoenzyme 1 ZAK 2q24.2 pyruvate dehydrogenase kinase, isoenzyme 1 LOC391461 2 similar to ribosomal protein S2; 40S ribosomal protein S2 CDCA7 2q31 cell division cycle associated 7 LOC344178 2q31.1 similar to peptidylprolyl isomerase A (cyclophilin A) LOC344181 2q31.1 similar to ribosomal protein L5; 60S ribosomal protein L5 SP3 2q31 Sp3 transcription factor LOC389061 2 LOC389061 LOC389062 2 LOC389062 LOC391462 2 similar to protein 40kD PTD004 2q31.1 hypothetical protein PTD004 LOC391463 2 similar to Leucine-rich repeat-containing protein 2 LOC389063 2 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) LOC389064 2 hypothetical gene supported by AK128215 CIR 2q31.1 CBF1 interacting corepressor SES3 2q31.1 secernin 3 GPR155 2q31.1 G protein-coupled receptor 155 WASPIP 2q31.1 Wiskott-Aldrich syndrome protein interacting protein LOC151561 2q31.2 similar to H3 histone, family 3B CHRNA1 2q31-q32 cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) CHN1 2q31-q32.1 chimerin (chimaerin) 1 ATF2 2q32 activating transcription factor 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 splicing 2839 51.4 450 - 2006 16580749
  • CDCA7-V1
  • encodes the longer isoform
  • 9 splicing 2602 42.6 371 - 2006 16580749
  • CDCA7-V2
  • lacks an internal region, as compared to isoform 1
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   lowly
     thymus   highly
    Cardiovascularheart    
    Digestiveintestinelarge intestinecolon highly
     intestinesmall intestine  highly
     liver    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to Drosophila CG13890
    homolog to C.elegans R06F6.9
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • participating in MYC-mediated transformation
  • MYC-responsive gene that participates in neoplastic transformation
  • being a unique transcription regulator whose expression is activated by E2F1 as well as MYC
  • is a recently identified target of MYC-dependent transcriptional regulation
  • is an evolutionary conserved NOTCH1 target involved in hematopoietic stem cell (HSC) emergence
  • ZBTB24, HELLS, CDCA7 gene products are not involved in establishing or maintaining subtelomeric methylation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • HELLS-CDCA7 complex possesses nucleosome remodeling activity
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MYC target gene
  • direct transcriptional target of transcription factor E2F1
  • CDCA7 associates with MYC and this association is modulated in a phosphorylation-dependent manner
  • ZBTB24 can likely function as a transcription factor directly controlling CDCA7 expression
  • cell & other
    REGULATION
    induced by c.Myc
    ASSOCIATED DISORDERS
    corresponding disease(s) ICF3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS