Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CDCA5 contributors: mct - updated : 03-09-2015
HGNC name cell division cycle associated 5
HGNC id 14626
Location 11q13.1      Physical location : 64.844.926 - 64.851.615
Synonym name
  • sororin
  • Synonym symbol(s) MGC16386
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    STRUCTURE 6.69 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    RASGRP2 11q13 RAS guanyl releasing protein 2 (calcium and DAG-regulated) PYGM 11q13.2 phosphorylase, glycogen; muscle (McArdle syndrome, glycogen storage disease type V) SF1 11q13.2 splicing factor 1 MAP4K2 11q13 mitogen-activated protein kinase kinase kinase kinase 2 MEN1 11q13.2 multiple endocrine neoplasia I HSMDPKIN 11q13 multiple endocrine neoplasia I EHD1 11q13 EH-domain containing 1 KIAA0404 11q13.3-q13.5 EH-domain containing 1 PPP2R5B 11q13 protein phosphatase 2, regulatory subunit B (B56), beta isoform GPHA2 11q13.1 glycoprotein hormone alpha 2 LOC283129 11q13.1 hypothetical protein LOC283129 LOC116071 11q13.1 hypothetical protein BC012330 SNX15 11q12 sorting nexin 15 ARL2 11q13 ADP-ribosylation factor-like 2 LOC390210 11 similar to Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1) (eEF1A-1) (Elongation factor Tu) (EF-Tu) HSU79266 11q13.1 protein predicted by clone 23627 NAALADL1 11q12 N-acetylated alpha-linked acidic dipeptidase-like 1 LOC256676 11q13.1 hypothetical LOC256676 CDCA5 11q12.1 cell division cycle associated 5 ZFPL1 11q13 zinc finger protein-like 1 C11orf2 11q13 chromosome 11 open reading frame2 TM7SF2 11q13 transmembrane 7 superfamily member 2 C11orf5 11q13 chromosome 11 open reading frame 5 FAU 11q12-q13.1 Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived); ribosomal protein S30 MRPL49 11q13 mitochondrial ribosomal protein L49 HRD1 11q13 HRD1 protein LOC387778 11 similar to p33 ringo LOC387779 11 similar to Phosphoglycerate mutase 1 (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1) CAPN1 11q13 calpain 1, (mu/I) large subunit LOC387780 11 similar to solute carrier family 22 member 6; organic cationic transporter-like 1; solute carrier family 22 (organic anion transporter), member 6 POLA2 11q13.1 polymerase (DNA-directed), alpha (70kD) CDC42EP2 11q13 CDC42 effector protein (Rho GTPase binding) 2 DPF2 11q13 D4, zinc and double PHD fingers family 2 TIGD3 11q13.2 tigger transposable element derived 3 LOC283130 11q13.1 hypothetical protein LOC283130 FKSG44 11q13 hypothetical protein FKSG44
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2599 - 252 - 2005 15837422
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systembreastmammary gland highly
    Respiratoryrespiratory tractlarynx  highly
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a KEN box for APC-dependent ubiquitination
  • highly conserved motif at the C terminus interacting with the cohesin complex is critical to its ability to mediate sister chromatid cohesion
  • HOMOLOGY
    interspecies homolog to Drosophila CG13890
    homolog to C.elegans R06F6.9
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase
  • regulates the ability of the cohesin complex to mediate sister chromatid cohesion, perhaps by altering the nature of the interaction of cohesin with the chromosomes
  • implicated in promoting cohesion through effects on cohesin complexes, and is involved in maintenance of cohesion in response to the spindle checkpoint
  • sororin (CDCA5) and Shugoshin (SGOL1) protect centromeric cohesion in response to the spindle checkpoint, but prevent the removal of cohesion by a mechanism independent of the APC/C
  • required for the increased stability of the cohesin complex on chromatin following DNA replication and sister chromatid cohesion during G2
  • associates with the cohesin complex and regulates the segregation of sister chromatids
  • cohesin dynamics are controlled by the releasing factors PDS5B and WAPL and the cohesin stabilizer CDCA5
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with chromatin-bound cohesin and functions during the establishment or maintenance of cohesion in S or G2 phase, respectively
  • interacting with SGOL1
  • interaction of sororin with cohesin, either directly or indirectly, is potentially important for function
  • stepwise loss of cohesion between chromosome arms and centromeres is caused by local regulation of WAPL activity, which is controlled by the phosphorylation state of CDCA5
  • in addition to recruiting PPP2CA to dephosphorylate cohesin and CDCA5, SGO1 physically shields cohesin from WAPL
  • SMC3 acetylation leads to recruitment of CDCA5, inhibition of WAPL, and stabilization of cohesin on DNA
  • cell & other
    REGULATION
    Other regulation by CDK1-mediated phosphorylation, and its phosphorylation causes its release from chromatin in mitosis
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in the majority of lung cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    suppression of the ERK-CDCA5 pathway could be a promising strategy for cancer therapy
    ANIMAL & CELL MODELS