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FLASH GENE
Symbol CDCA4 contributors: mct - updated : 26-08-2019
HGNC name cell division cycle associated 4
HGNC id 14625
Location 14q32.33      Physical location : 105.475.909 - 105.487.425
Synonym name hematopoeitic progenitor protein
Synonym symbol(s) HEPP, FLJ20764, TRIP-BR3, FLJ52878, MGC19517, SEI-3/HEPP
DNA
TYPE functioning gene
STRUCTURE 11.51 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure
  • an E2F-responsive sequence in the vicinity of the transcription initiation site is necessary for the E2F1-4-induced activation of CDCA4 gene transcription
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 splicing 2453 26.1 241 - 2001 11482882
  • containing an additional segment in the 3' UTR
  • encoding the same protein
  • 3 splicing 1927 26.1 241 - 2001 11482882
  • encoding the same protein
  • lacking the additional segemt in the 3' UTR
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveesophagus   highly
     liver   highly
    Lymphoid/Immunelymph node   highly
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly Homo sapiens
    Connectivebone   
    Lymphoid    
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmature hematopoietic Homo sapiens
    Blood/Hematopoieticprogenitor cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text progenitor cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal KRKC domain appears to be the nuclear localization signal
  • a SERTA motif in addition to cyclin A-binding and PHD bromodomain-binding regions of homology
  • HOMOLOGY
    interspecies homolog to Drosophila CG13890
    homolog to C.elegans R06F6.9
    homolog to murine Hepp
    intraspecies homolog to SERTAD3
    Homologene
    FAMILY
  • SERTA domain family of proteins
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text
  • localizes at metaphase spindle poles and the midzone in later stages
  • resides predominantly in the nucleus throughout all stages of the cell cycle
  • basic FUNCTION
  • molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation
  • stimulate TP53 activity and also lead to TP53-independent growth inhibition when overexpressed
  • may likely be involved in the development of a range of tissues during embryogenesis
  • is likely to also play an important role in embryogenesis (pMID: 16546331)
  • may be acting as a dormant regulator of the TRIP-Br family awaiting proper regulatory cues
  • functions as a suppressor at the E2F-responsive promoter
  • participates in the regulation of cell proliferation, mainly through the E2F/retinoblastoma protein pathway
  • transcriptional co-factor CDCA4 participates in the regulation of JUN oncogene expression
  • nuclearmitotic apparatus protein, involved in spindle organization from prometaphase
  • when anaphase begins, may play a different role as a midzone factor involved in chromosome segregation or cytokinesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a target gene of transcription factor E2F and represses E2F-dependent transcriptional activation and cell proliferation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    targeting CDCA4 expression could be useful as a novel strategy in future triple negative breast cancer treatment
    ANIMAL & CELL MODELS