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FLASH GENE
Symbol CDCA4 contributors: mct - updated : 15-02-2011
HGNC name cell division cycle associated 4
HGNC id 14625
Location 14q32.33      Physical location : 105.475.909 - 105.487.425
Synonym name hematopoeitic progenitor protein
Synonym symbol(s) HEPP, FLJ20764, TRIP-BR3, FLJ52878, MGC19517, SEI-3/HEPP
DNA
TYPE functioning gene
STRUCTURE 11.22 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure
  • an E2F-responsive sequence in the vicinity of the transcription initiation site is necessary for the E2F1-4-induced activation of CDCA4 gene transcription
  • MAPPING cloned Y linked N status provisional
    Physical map
    LOC388021 14 similar to expressed sequence AI839735 MGC13251 14q32.33 hypothetical protein MGC13251 FLJ22056 14q32.33 hypothetical protein FLJ22056 LOC388022 14 hypothetical gene supported by AK131040 ADSSL1 14q32.33 adenylosuccinate synthase like 1 SIVA 14q32.33 CD27-binding (Siva) protein AKT1 14q32.32 v-akt murine thymoma viral oncogene homolog 1 LOC390508 14 similar to MGC53446 protein MGC23270 14q32.33 hypothetical protein MGC23270 RPS2P4 14q32.33 ribosomal protein S2 pseudogene 4 KIAA0284 14q32.33 KIAA0284 LOC122618 14q32.33 hypothetical protein BC015003 C14orf78 14 chromosome 14 open reading frame 78 C14orf157 14q32.33 chromosome 14 open reading frame 157 C14orf79 14q32.33 chromosome 14 open reading frame 79 CDCA4 14q32.33 cell division cycle associated 4 GPR132 14q32.3 G protein-coupled receptor 132 JAG2 14q32 jagged 2 NUDT14 14q32.33 nudix (nucleoside diphosphate linked moiety X)-type motif 14 LOC390509 14 similar to chloride intracellular channel 6; chloride channel form A BRF1 14q32.33 BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae) BTBD6 14q32 BTB (POZ) domain containing 6 MTA1 14q32.3 metastasis associated 1 CRIP1 7q11.23 cysteine-rich protein 1 (intestinal) CRIP2 14q32.3 cysteine-rich protein 2 LOC388024 14 LOC388024 C14orf80 14q32.33 chromosome 14 open reading frame 80
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 2453 26.1 241 - 2001 11482882
  • containing an additional segment in the 3' UTR
  • encoding the same protein
  • - splicing 1927 26.1 241 - 2001 11482882
  • encoding the same protein
  • lacking the additional segemt in the 3' UTR
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveesophagus   highly
     liver   highly
    Lymphoid/Immunelymph node   highly
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly Homo sapiens
    Connectivebone   
    Lymphoid    
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmature hematopoietic Homo sapiens
    Blood/Hematopoieticprogenitor cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text progenitor cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal KRKC domain appears to be the nuclear localization signal
  • HOMOLOGY
    interspecies homolog to Drosophila CG13890
    homolog to C.elegans R06F6.9
    homolog to murine Hepp
    Homologene
    FAMILY
  • TRIP-Br family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text localizes at metaphase spindle poles and the midzone in later stages
    basic FUNCTION
  • molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation
  • stimulate TP53 activity and also lead to TP53-independent growth inhibition when overexpressed
  • may be acting as a dormant regulator of the TRIP-Br family awaiting proper regulatory cues
  • functions as a suppressor at the E2F-responsive promoter
  • participates in the regulation of cell proliferation, mainly through the E2F/retinoblastoma protein pathway
  • transcriptional co-factor CDCA4 participates in the regulation of JUN oncogene expression
  • nuclearmitotic apparatus protein, involved in spindle organization from prometaphase
  • when anaphase begins, may play a different role as a midzone factor involved in chromosome segregation or cytokinesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS