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FLASH GENE
Symbol CDCA3 contributors: npt/mct - updated : 28/10/2008
HGNC name cell division cycle associated 3
HGNC id 14624
Location 12p13      Physical location : 6.957.971 - 6.960.456
Synonym name
  • trigger of mitotic entry protein 1
  • gene-rich cluster protein C8
    • Synonym symbol(s) TOME-1, GRCC8, C8, MGC2577
    DNA
    TYPE functioning gene
    STRUCTURE 2.43 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (CAAT box)
    text structure . promoter activity is activated at the G2/M phase
  • CCAAT box located upstream of the transcription initiation site is important for the basal promoter activity
  • a repressor element (cell-cycle-dependent element/cell cycle gene homology region) in the vicinity of the transcription start site
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1170 28 268 - Yoshida (2005)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
    Lymphoid/Immunelymph node   highly
     thymus   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to Drosophila CG13890
    homolog to C.elegans R06F6.9
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • mediates the destruction of mitosis-inhibitory kinase WEE1 via E3 ligase KITLG
  • required for proper activation of CDC2/cyclin B and mitotic entry
  • may trigger entry into mitosis by interfering with this kinase/phosphatase 'switch'
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein substrate of APC
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS