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FLASH GENE
Symbol CDCA2 contributors: npt/mct - updated : 24-09-2015
HGNC name cell division cycle associated 2
HGNC id 14623
Location 8p21.2      Physical location : 25.316.512 - 25.365.425
Synonym name
  • recruits PP1 onto mitotic chromatin at anaphase protein
  • protein phosphatase 1 [gamma] (PPP1R3A) binding protein Repo-Man
  • Synonym symbol(s) Repo-Man, FLJ25804, MGC129906, MGC129907, PPP1R81
    DNA
    TYPE functioning gene
    STRUCTURE 48.91 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 3735 - 1023 - 2006 1649280
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • PPP1CA binding domain
  • HOMOLOGY
    interspecies homolog to Drosophila CG13890
    homolog to C.elegans R06F6.9
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • forms an essential complex with PPP1CA gamma and is required for the recruitment of PPP1CA to chromatin
  • controls a protein phosphatase 1-dependent threshold for DNA damage checkpoint activation
  • is a key factor that coordinates chromatin remodeling and early events of nuclear envelope reformation during mitotic exit
  • might be associated closely with oral squamous cell carcinoma (OSCC) progression by preventing cell-cycle arrest and apoptosis
  • is a targeting subunit for the protein phosphatase 1 involved in the dephosphorylation of histone H3 during mitotic exit
  • is also essential for proper nuclear envelope reformation and the regulation of DNA damage responses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complex CDCA2/PPP1CA inactivating mitotic chromosome structure during anaphase
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PPP1CA binding protein, which selectively recruits PPP1CAgamma onto mitotic chromatin at anaphase and into the following interphase
  • co-operating with condensin in the regulation of chromosome architecture during mitosis
  • two PP1-targeting subunits, PPP1R7 and CDCA2, counteracted AURKB-dependent phosphorylation of the outer kinetochore component DSN1 during anaphase
  • recruits protein phosphatase 1 to chromatin to antagonize activation of ataxia telangiectasia mutated (ATM)-dependent signal transduction
  • CDCA2-associated PP1 and PP2A collaborate to oppose the chromosomal targeting of AURKB
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    up-regulated in oral squamous cell carcinoma (OSCC) cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a very strong prognostic marker for poor patient survival in cancer
  • Therapy target
    ANIMAL & CELL MODELS