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FLASH GENE
Symbol CDC7 contributors: mct - updated : 04-01-2012
HGNC name CDC7 cell division cycle 7 (S. cerevisiae)
HGNC id 1745
Location 1p22.2      Physical location : 91.966.403 - 91.991.320
Synonym name
  • CDC7 cell division cycle 7-like 1 (S. cerevisiae)
  • Cell division cycle 7, S. Cerevisiae, homolog-like 1
  • Synonym symbol(s) HSK1, CDC7L1, MGC117361, MGC126237, MGC126238
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 24.92 kb     12 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    FLJ20403 1p22.2 hypothetical protein FLJ20403 BARHL2 1p22 BarH-like 2 (Drosophila) LOC388648 1 LOC388648 LOC343474 1p22.2 similar to Phosphorylase B kinase alpha regulatory chain, skeletal muscle isoform (Phosphorylase kinase alpha M subunit) KIAA1221 1p22.1 similar to Phosphorylase B kinase alpha regulatory chain, skeletal muscle isoform (Phosphorylase kinase alpha M subunit) BM-005 LOC391054 1 similar to ribosomal protein L5; 60S ribosomal protein L5 FLJ36760 1p22.2 FLJ36760 protein LOC284696 1p22.2 similar to flap structure-specific endonuclease 1; maturation factor-1; DNase IV LOC391055 1 similar to hypothetical protein LOC164045 1p22.2 hypothetical protein LOC164045 CDC7 1p22 CDC7 cell division cycle 7 (S. cerevisiae) LOC391056 1 similar to RIKEN cDNA 9430077D24 gene TRAP2 1p22 tumor rejection antigen (gp96) pseudogene 2 TGFBR3 1p33-p32 transforming growth factor, beta receptor III (betaglycan, 300kDa) BRDT 1p21-p22 bromodomain, testis-specific ABHD7 1p22.1 abhydrolase domain containing 7 LOC339526 1p22.1 similar to hypothetical protein FLJ20481 LOC126598 1p22.1 similar to template acyivating factor-I alpha LOC284697 1p22.1 similar to agCP5986 KIAA1107 1p22.1 KIAA1107 protein LOC388649 1 similar to 1700028K03 protein GLMN 1p22.1 glomulin, FKBP associated protein FLJ13150 1p22.1 hypothetical protein FLJ13150 GFI1 1p22 growth factor independent 1 EVI5 1p22 ecotropic viral integration site 5 RPL5 1p22.1-p21.3 ribosomal protein L5 LOC388650 1 similar to RIKEN cDNA 2900024C23
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 3222 63 574 - 2007 17711849
    12 - 3188 - 574 - 2007 17711849
    12 - 3316 - 574 - 2007 17711849
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, interphase, S
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a protein kinase domain
  • C-terminal 143-amino acid polypeptide (432-574) containing DAM-1 and DAM-2 can interact with DBF4
  • mono polymer complex
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae cdc7p
    homolog to murine Cdc7 (81.4pc)
    intraspecies homolog to cell division cycle CDC7 related kinase
    Homologene
    FAMILY
  • protein kinase superfamily
  • ser/thr protein kinase family
  • CDC7 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text nuclear import is mediated directly by importin-beta
    basic FUNCTION
  • serine/threonine kinase, putative regulator of G1/S phase transition and so cell cycle progression
  • playing an essential role in meiotic process
  • activating the initiation of DNA replication by modulating MCM functions (phosphorylating, MCM4, MCM2 proteins)
  • involved in initiation and progression of DNA replication
  • CDC7-DBF4 is a conserved protein kinase required for the initiation of DNA replication
  • CDC7-DBF4 prevents inappropriate exit from mitosis by inhibiting Polo kinase and functions in the spindle position checkpoint
  • phosphorylates the minichromosome maintenance protein 2 (MCM2), a component of the DNA replicative helicase needed for genome duplication
  • play a key role in the regulation of initiation at each replication origin
  • CELLULAR PROCESS cell cycle,division,meiosis
    cell cycle, progression
    nucleotide, replication
    PHYSIOLOGICAL PROCESS
    text
  • regulator of DNA replication
  • PATHWAY
    metabolism
    signaling
    a component
  • forming a complex with either DBF4/DBF4A or DBF4B, leading to the activation of the kinase activity
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP binding
  • protein
  • interacting with CRM1, leading to the translocation of CDC7 from nucleus to cytoplasm
  • interacts with and phosphorylates Claspin (CLSPN) (CDC7 is potentially required for activation of the ATR-CHEK1 checkpoint pathway through regulation of Claspin)
  • RAD18 is a substrate of the essential protein kinase CDC7
  • CDC7-DBF4 interaction with CDC5
  • bipartite interaction between CDC7 and DBF4 subunits facilitates ATP binding and substrate recognition by the CDC7 kinase
  • role for CDC7 -mediated phosphorylation of MCM2 in the response to replicative stress, including some forms of DNA damage
  • cell & other
    REGULATION
    Other may be down-regulated by the binding of CRM1, masking its kinase domain
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    overexpression of the protein may be associated with neoplastic transformation for some tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    inhibition of CDC7 kinase activity in cancer cells restricts DNA replication and induces apoptotic cell death by an unprecedented molecular mechanism of action
    cancerreproductiveovary
    potent anticancer target in epithelial ovarian carcinoma
    ANIMAL & CELL MODELS