basic FUNCTION
| required for the initiation of DNA replication regulated by p53 through CDC6 protein stability |
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acting as a regulator at the early steps of DNA replication |
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substrate for the APC/C complex |
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CDC6 stabilization by cyclin E promotes pre-RC assembly |
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participating in checkpoint controls that ensure DNA replication is completed before mitosis is initiated |
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plays a key role in the sequential molecular events leading to repression of origin licensing and loss of proliferative capacity during execution of the differentiation programme |
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also plays important roles in the activation and maintenance of the checkpoint mechanisms that coordinate S phase and mitosis |
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essential for DNA replication and its deregulation is involved in carcinogenesis |
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with CDT1 are destabilized by rereplication-induced DNA damage |
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essential to promote the assembly of pre-replicative complexes in the early G1 phase of the cell cycle, a process requiring tight regulation to ensure that proper origin licensing occurs once per cell cycle |
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acts as a molecular switch at the CDH1 locus, linking transcriptional repression to activation of replication |
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role in spindle formation in addition to its role as a DNA replication factor |
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during the G(1)-S transition, is essential for chromosomal replication is activated by the E2F transcriptional factor |
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is an AAA+ ATPase with three functions, all working for life |