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FLASH GENE
Symbol CDC5L contributors: mct/pgu - updated : 02-06-2015
HGNC name CDC5 cell division cycle 5-like (S. pombe)
HGNC id 1743
Location 6p21.1      Physical location : 44.355.301 - 44.414.779
Synonym name
  • Cdc5-related protein
  • cell division cycle 5, S. pombe, homolog-like
  • dJ319D22.1 (CDC5-like protein)
  • pombe cdc5-related protein
  • Cdc5-like protein
  • Synonym symbol(s) CDC5RP, KIAA0432, CEF1, hCDC5, PCDC5RP, dJ319D22.1
    DNA
    TYPE functioning gene
    STRUCTURE 59.48 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map pter - D6S271 /D6S451 /D6S282 - [ ] - D6S459 - cen
    Text [ ]:breakpoint in CDC5L
    Physical map
    VEGF 6p12 vascular endothelial growth factor LOC389392 6 LOC389392 MGC45491 6p21.1 hypothetical protein MGC45491 LOC391921 6 similar to 60S ribosomal protein L29 (Cell surface heparin binding protein HIP) MRPL14 6p21.3 mitochondrial ribosomal protein L14 C6orf110 6p21.1 chromosome 6 open reading frame 110 CAPN11 6p12 calpain 11 LOC389393 6 LOC389393 SLC29A1 6p21.2-p21.1 solute carrier family 29 (nucleoside transporters), member 1 HSPCB 6p12 heat shock 90kDa protein 1, beta SLC35B2 6p12.1-p11.2 solute carrier family 35, member B2 NFKBIE 6p21.1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon LOC391922 6 similar to hypothetical protein MGC33486 MGC33600 6p21.1 hypothetical protein MGC33600 AARSL 6p21.1 alanyl-tRNA synthetase like SPATS1 6p21.1 spermatogenesis associated, serine-rich 1 CDC5L 6p21 CDC5 cell division cycle 5-like (S. pombe) SUPT3H 6p21.3-p21.1 suppressor of Ty 3 homolog (S. cerevisiae)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 3012 - 802 - 2008 18583928
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text fetal tissue
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two HTH myb-type DNA binding domains
  • conjugated PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Cdc5l (98.0pc)
    homolog to rattus Cdc5l (97.9pc)
    intraspecies homolog to CDC5-like-sequence
    homolog to Myb
    Homologene
    FAMILY
  • CEF1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text may shuttle between cytoplasm and nucleus
    basic FUNCTION
  • acts as a positive regulator of cell cycle G2/M progression
  • may act as a transcriptional activator
  • seems to be involved in the second catalytic step of pre-mRNA splicing
  • a cell cycle regulator important for the G2-M transition, that possesses potential oncogenic activity in osteosarcoma
  • involved in the cellular response to DNA damage
  • is required for the activation of downstream effectors or mediators of ATR checkpoint function such as CHEK1, RAD17 and FANCD2
  • spliceosomal subcomplex that also plays a role in DNA repair
  • CELLULAR PROCESS cell cycle, checkpoint
    cell cycle, progression
    nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the spliceosome complex (CDC5l, PLRG1, SPF27, CCAP1, CCAP3, CCAP6)
  • INTERACTION
    DNA binding to adeno-pre-mRNA in an ATP-stimulated manner
    RNA
    small molecule
    protein
  • interaction between CDC5L and PLRG1 essential for pre-mRNA splicing
  • interacting with DAPK3
  • interacting with ATR
  • CTNNBL1 associates with the PRPF19 complex of the spliceosome, interacting with its CDC5L component
  • BCAS2 directly interacts with each component of the PRPF19/CDC5L complex core
  • interaction between HNRPM and the spliceosome proteins cell division cycle 5-like (CDC5L) and pleiotropic regulator 1 (PLRG1) that was inhibited during the heat-shock stress response
  • cell & other
    REGULATION
    Other phosphorylation of CDC5L is required for CDC5L-mediated pre-mRNA splicing
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    translocation t(6;19) (p21;q13),in multicystic renal dysplasia (see also PUJO)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • may be an oncogene for the 6p12-p21 amplicon found in osteosarcoma
  • Marker
    Therapy target
    ANIMAL & CELL MODELS