protein
| bind directly to minichromosome maintenance 7 protein (MCM7) and to the p70 subunit of DNA polymerase alpha (Kukimoto 1999) |
|
DNA polymerase alpha |
|
ORC2L |
|
associates with CDT1 and CDC7 kinase (CDT1 recruiting CDC45 to chromatin) (Ballabeni 2009) |
|
interacting with TOPBP1 (required for chromatin loading of the replication protein CDC45) (Schmidt 2008) |
|
interacts with the putative eukaryotic replicative DNA helicase, the MCM (mini-chromosome maintenance) complex, and forms a helicase active 'supercomplex', the CMG [Cdc45-MCM2-7-GINS (go-ichi-ni-san)] complex (Broderick 2009) |
|
coordinated binding of DTD1 and CDC45 to origins and the physical interactions of DTD1, CDC45, and TOPBP1 suggest that complexes of these proteins are necessary for replication initiation |
|
GINS1, GINS2, GINS3, GINS4 and TICRR compete with one another for MCM2-7 and CDC45 binding |
|
is a critical effector of myc-dependent DNA replication stress |
|
MCM10 and CDC45 directly interact and establish a mutual co-operation in DNA binding |
|
HELB interacts directly with two initiation factors TOPBP1 and CDC45 (both, the N-terminus and helicase domain of HELB bind to the N-terminus of CDC45) |
|
initiation factor TICRR coordinating the assembly and activation of the eukaryotic replication fork helicase by recruiting CDC45 to MCM2-7 |