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FLASH GENE
Symbol CDC42EP2 contributors: npt/mct - updated : 24/10/2008
HGNC name CDC42 effector protein (Rho GTPase binding) 2
HGNC id 16263
Location 11q13      Physical location : 65.082.330 - 65.089.899
Synonym name
  • binder of RhoGTPases 1
  • CRIB-containing BOGR1 protein
  • Synonym symbol(s) CEP2, BORG1
    DNA
    TYPE functioning gene
    STRUCTURE 7.57 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    PPP2R5B 11q13 protein phosphatase 2, regulatory subunit B (B56), beta isoform GPHA2 11q13.1 glycoprotein hormone alpha 2 LOC283129 11q13.1 hypothetical protein LOC283129 LOC116071 11q13.1 hypothetical protein BC012330 SNX15 11q12 sorting nexin 15 ARL2 11q13 ADP-ribosylation factor-like 2 LOC390210 11 similar to Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1) (eEF1A-1) (Elongation factor Tu) (EF-Tu) HSU79266 11q13.1 protein predicted by clone 23627 NAALADL1 11q12 N-acetylated alpha-linked acidic dipeptidase-like 1 LOC256676 11q13.1 hypothetical LOC256676 CDCA5 11q12.1 cell division cycle associated 5 ZFPL1 11q13 zinc finger protein-like 1 C11orf2 11q13 chromosome 11 open reading frame2 TM7SF2 11q13 transmembrane 7 superfamily member 2 C11orf5 11q13 chromosome 11 open reading frame 5 FAU 11q12-q13.1 Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived); ribosomal protein S30 MRPL49 11q13 mitochondrial ribosomal protein L49 HRD1 11q13 HRD1 protein LOC387778 11 similar to p33 ringo LOC387779 11 similar to Phosphoglycerate mutase 1 (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1) CAPN1 11q13 calpain 1, (mu/I) large subunit LOC387780 11 similar to solute carrier family 22 member 6; organic cationic transporter-like 1; solute carrier family 22 (organic anion transporter), member 6 POLA2 11q13.1 polymerase (DNA-directed), alpha (70kD) CDC42EP2 11q13 CDC42 effector protein (Rho GTPase binding) 2 DPF2 11q13 D4, zinc and double PHD fingers family 2 TIGD3 11q13.2 tigger transposable element derived 3 LOC283130 11q13.1 hypothetical protein LOC283130 FKSG44 11q13 hypothetical protein FKSG44 LOC387781 11 similar to UBIQUITIN-LIKE PROTEIN FUBI SCYL1 11q11-q12 SCY1-like 1 (S. cerevisiae) LTBP3 11q12 latent transforming growth factor beta binding protein 3 MTVR1 11q23 Mouse Mammary Turmor Virus Receptor homolog 1 SSSCA1 11q13.1 Sjogren's syndrome/scleroderma autoantigen 1 DKFZp762C186 11q13.1 tangerin KCNK7 11q13 potassium channel, subfamily K, member 7 MAP3K11 11q13.3 mitogen-activated protein kinase kinase kinase 11
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2001 22 210 - Joberty (2001)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveesophagus   highly
     liver   lowly
    Endocrinepancreas   lowly
     thyroid   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal CRIB motif
  • a conserved 12AA BORG-homology 1 (BH1)
  • 11AA BH2 domain in the central region
  • 22AA BH3 domain at the C terminus
  • a Cdc42 binding domain
  • two unique domains called CI and CII
  • HOMOLOGY
    interspecies homolog to murine Cep2
    homolog to Drosophila CG3493
    homolog to C.elegans T10G3.5
    Homologene
    FAMILY
  • CDC42 binding protein family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    text perinuclear cytoplamsic compartment
    basic FUNCTION regulator of mammalian septin organization
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP
    protein
  • binding to TC10 and CDC42
  • bind to septin GTPases
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS