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FLASH GENE
Symbol CDC42BPA contributors: - updated : 23-11-2004
HGNC name CDC42 binding protein kinase alpha (DMPK-like)
HGNC id 1737
Location 1q41-q42      Physical location : 227.177.566 - 227.505.826
Synonym name
  • ser-thr protein kinase PK428
  • CDC42 binidng protein kinase beta
  • CDC42-binding protein kinase alpha (DMPK-like)
  • myotonic dystrophy kinase-related CDC42-binding protein kinase alpha
  • ser-thr protein kinase related to the myotonic dystrophy protein kinase
  • Synonym symbol(s) MRCK, MRCKA, PK428, FLJ23347, KIAA0451
    EC.number 2.7.1.37
    DNA
    TYPE functioning gene
    STRUCTURE 325.00 kb     41 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status provisional
    Physical map
    SRP9 1q42.13 signal recognition particle 9kDa LEFTY3 1q42.1 LEFTY family pseudogene EPHX1 1q42.1 epoxide hydrolase 1, microsomal (xenobiotic) KIAA0792 1q42.13 epoxide hydrolase 1, microsomal (xenobiotic) LEFTB 1q42.1 left-right determination, factor B P5CR2 1q42.13 pyrroline 5-carboxylate reductase isoform EBAF 1q42.1 endometrial bleeding associated factor (left-right determination, factor A; transforming growth factor beta superfamily) FLJ35382 1q42.13 hypothetical protein FLJ35382 H3F3A 1q41 H3 histone, family 3A ACBD3 1q42.13 acyl-Coenzyme A binding domain containing 3 MIXL1 1q41 Mix1 homeobox-like 1 (Xenopus laevis) TGS 1q42.13 TUDOR gene similar ADPRT 1q42 ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) LOC391168 1 similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1 LOC391169 1 similar to hypothetical protein D11Ertd497e LOC388748 1 LOC388748 LOC388749 1 LOC388749 ITPKB 1q41-q42 inositol 1,4,5-trisphosphate 3-kinase B LOC391170 1 similar to hypothetical protein PSEN2 1q42.1 presenilin 2 (Alzheimer disease 4) CABC1 1q42.11 chaperone, ABC1 activity of bc1 complex like (S. pombe) CDC42BPA 1q42.11 CDC42 binding protein kinase alpha (DMPK-like) LOC343363 1q42.13 similar to basic transcription factor 3 LOC391171 1 similar to beta-tubulin 4Q LOC255208 1q42.13 HSA1q42.3 beta-tubulin 4Q pseudogene MGC42493 1q42.13 hypothetical protein MGC42493 MRP63P2 1q42.13 mitochondrial ribosomal protein 63 pseudogene 2 MGC15634 1q42.13 hypothetical protein MGC15634 FLJ12517 1q42.13 hypothetical protein FLJ12517 IMAGE3451454 1q42.13 SVAP1 protein MPN2 1q42.13 marapsin 2 WNT9A 1q42 wingless-type MMTV integration site family, member 9A LOC340346 1q42.13 hypothetical gene supported by AK093729; AK096776; AL117642 LOC391173 1 similar to capicua homolog WNT3A 1q42 wingless-type MMTV integration site family, member 3A DKFZp434C0923 1q42.13 hypothetical protein DKFZp434C0923 ARF1 1q42 ADP-ribosylation factor 1 C1orf35 1q42.13 chromosome 1 open reading frame 35 MRPL55 1p36.3 mitochondrial ribosomal protein L55 LOC391174 1 similar to hypothetical protein FLJ22875
    regionally located same location than STK6P, same gene ?
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 8019 195 1719 - Tan
    - - 7776 186 1638 - Tan
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinepancreas    
    Nervousbrain    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines various cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal domain
  • highly similar to the kinase kinase domain of DMPK followed by a predicted helical domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Pk428
    Homologene
    FAMILY Ser/Thr protein kinase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • protein serine/threonine kinase activity
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP binding
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS