basic FUNCTION
| potential regulator of cell cycle progression |
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protein kinase targeting subunit of HSP90 that binds and stabilizes CDK4 (HSPC*) |
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regulator of the stress-responsive mitogen-activated protein kinase |
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play a critical role in directing Hsp90 to its target kinases |
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important for CDK4 stability and play a positive role in cell cycle progression |
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crucial element in the protein signaling pathway |
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promotes the association of HSP90 with the protein kinase subset of client proteins to maintain their stability and signalling functions |
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essential role for CDC37 in concert with HSP90 in maintaining oncogenic protein kinase clients |
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HSP90AA2 and CDC37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail |
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plays potentially an essential role in regulating RYK ICD stability and therefore in RYK-mediated signal transduction |
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co-chaperone that can regulate aspects of tau pathogenesis |
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CDC37 is essential for the stability of TARDBP and can be affected by MAPT accumulation |