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FLASH GENE
Symbol CDC37 contributors: shn/npt - updated : 17-07-2012
HGNC name CDC37 cell division cycle 37 homolog (S. cerevisiae)
HGNC id 1735
Location 19p13.2      Physical location : 10.501.808 - 10.514.271
Synonym name
  • cell division cycle 37 protein
  • CDC37 cell division cycle 37 homolog
  • Hsp90 co-chaperone Cdc37
  • Hsp90 chaperone protein kinase-targeting subunit p50Cdc37
  • CDC37 (cell division cycle 37, S. cerevisiae, homolog
    Synonym symbol(s) P50CDC37, CDC37A
    DNA
    TYPE functioning gene
    STRUCTURE 12.46 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D19S586 - D19S583 - Cdc37 - D8S2285 - D19S584 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1693 44.5 378 - 2003 12861001
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     liver    
    Nervousbrain     Homo sapiens
    Reproductivefemale systemuteruscervix  
    Skin/Tegumentskin   highly
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal, pregnancy
    Text small intestine, stomach, proliferating zones during development, placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N-terminal domain (residues 1127)contains a unique phosphorylation site for CKII kinase
  • a middle domain (residues 147276) comprises the Hsp90 binding site and a putative dimerization region
  • and a C-terminal domain (residues 283378)
  • conjugated PhosphoP
    mono polymer monomer
    HOMOLOGY
    interspecies ortholog to cdc37, Danio rerio
    homolog to CDC37, Saccharomyces cerevisiae
    ortholog to Cdc37, Mus musculus
    ortholog to CDC37, Pan troglodytes
    ortholog to Cdc37, Rattus norvegicus
    Homologene
    FAMILY
  • CDC37 family
  • CATEGORY chaperone/stress , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text
  • colocalizing with HSP90
  • co-localize with MAPT in neuronal cells and to physically interact with MAPT from human brain
  • basic FUNCTION
  • potential regulator of cell cycle progression
  • protein kinase targeting subunit of HSP90 that binds and stabilizes CDK4 (HSPC*)
  • regulator of the stress-responsive mitogen-activated protein kinase
  • play a critical role in directing Hsp90 to its target kinases
  • important for CDK4 stability and play a positive role in cell cycle progression
  • crucial element in the protein signaling pathway
  • promotes the association of HSP90 with the protein kinase subset of client proteins to maintain their stability and signalling functions
  • essential role for CDC37 in concert with HSP90 in maintaining oncogenic protein kinase clients
  • HSP90AA2 and CDC37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail
  • plays potentially an essential role in regulating RYK ICD stability and therefore in RYK-mediated signal transduction
  • co-chaperone that can regulate aspects of tau pathogenesis
  • CDC37 is essential for the stability of TARDBP and can be affected by MAPT accumulation
  • CELLULAR PROCESS cell cycle, progression
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • high molecular weight complex with HSP90 and CDK4
  • CDC37-HSP90 complexes are responsive to nucleotide-induced conformational changes and binding of further cofactors
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Hsp90, CDK4, CDK6, SRC, RAF-1, MOK, and eIF2 alpha kinases
  • androgen receptor (AR), ErbB2, Sti1 and lkb1
  • I-kappa-B kinase (IKK)
  • is a RYK intracellular domain (ICD)-interacting protein that inhibits proteasomal degradation of the RYK ICD
  • FGFR3 associates with Hsp90 and CDC37
  • HSP90AA1 and CDC37 cochaperone complex-mediated protein folding is thus an important part of the RIPK3 activation process during necroptosis.
  • cell & other
  • hyaluronan binding protein
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    loss of CDC37 function induces irreversible growth arrest in androgen receptor-positive and -negative prostate carcinoma cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    therapeutic potential of targeting CDC37 in cancer
    cancerreproductiveprostate
    essential for maintaining prostate tumor cell growth and may represent a novel target in the search for multitargeted therapies based on the HSP90 chaperone system
    neurologyneurodegenerativealzheimer
    new therapeutic targets that could be used to effectively treat neurologic devastating diseases (Alzheimer disease)
    ANIMAL & CELL MODELS