Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CDC23 contributors: - updated : 07-02-2006
HGNC name CDC23 (cell division cycle 23, yeast, homolog)
HGNC id 1724
Location 5q31.1      Physical location : 137.523.340 - 137.549.032
Synonym name anaphase-promoting complex subunit 8
Synonym symbol(s) HGNC1724, APC8
DNA
TYPE functioning gene
STRUCTURE 25.00 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map cen - D5S500 - CDC25C - EGR1 - CTNNA1 - CDC23 - KIAA0141 - FGF1 - HARS - HDAC3 - HBEGF - NR3C1 - qter
Authors Zhao (98)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • TPR protein containing nine tetratricopeptide repeats implicated in protein-protein interactions
    • mono polymer heteromer , complex
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae CDC23
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • involved in ubiquitin mediated proteolysis of B-type cycline
  • cell cycle control:mitotic metaphase/anaphase transition
    • CELLULAR PROCESS cell cycle, division, mitosis
    protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the anaphase promoting/cyclosome complex (APC/C) which is a large E3 ubiquitin ligase containing at least ten different, evolutionarily conserved components
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in myeloid leukemia (but unlikely involved in the pathogenesis of this disease)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS