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FLASH GENE
Symbol CDC20 contributors: mct/pgu - updated : 22-12-2015
HGNC name CDC20 cell division cycle 20 homolog (S. cerevisiae)
HGNC id 1723
Location 1p34.2      Physical location : 43.824.625 - 43.828.871
Synonym name cell division cycle 20
Synonym symbol(s) CDC55, p55CDC, MGC102824, bA276H19.3, CDC20A, APC/C(Cdc20)
DNA
TYPE functioning gene
STRUCTURE 4.25 kb     11 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D9S175 - D9S167 - D9S1812 - CDC20 /D9S1680 - D9S257 - qter
Physical map
PPIH 1p34.1 peptidyl prolyl isomerase H (cyclophilin H) NSEP1 1p34 nuclease sensitive element binding protein 1 CLDN19 1p33-34.2 claudin 19 LEPRE1 1p34.1 leucine proline-enriched proteoglycan (leprecan) 1 MGC955 1p34.1 hypothetical protein MGC955 LOC388624 1 LOC388624 ERMAP 1p34.1 erythroblast membrane-associated protein LOC51058 1p34.1 hypothetical protein LOC51058 LOC391032 1 similar to EVIN1; expressed in activated T/LAK lymphocytes LOC391033 1 similar to Makorin 1 LOC343515 1p34.1 similar to ATPase, H+ transporting, lysosomal 31kD, V1 subunit E isoform 1; V-ATPase, subunit E; H(+)-transporting two-sector ATPase, 31kDa subunit; H+-transporting ATP synthase chain E, vacuolar; vacuolar proton pump, 31-kd subunit SLC2A1 1p35-p31.3 solute carrier family 2 (facilitated glucose transporter), member 1 EBNA1BP2 1p35-p33 EBNA1 binding protein 2 FLJ32000 1p34.1 hypothetical protein FLJ32000 LOC256339 1p34.1 similar to ENSANGP00000010412 MGC17299 1p34.1 hypothetical protein MGC17299 MGC52423 1p34.1 hypothetical protein MGC52423 TIE 1p34 tyrosine kinase with immunoglobulin and epidermal growth factor homology domains CDC20 9q13-q21 CDC20 cell division cycle 20 homolog (S. cerevisiae) MPL 1p34 myeloproliferative leukemia virus oncogene ELOVL1 1p34.1 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1 MED8 1p34.1 mediator of RNA polymerase II transcription, subunit 8 homolog (yeast) LOC388625 1 similar to FLJ00408 protein HT036 1p34.1 hypothetical protein HT036 PTPRF 1p34 protein tyrosine phosphatase, receptor type, F JMJD2 1p34.1 jumonji domain containing 2 SIAT6 1p34.1 sialyltransferase 6 (N-acetyllacosaminide alpha 2,3-sialyltransferase) ARTN 1p32-p31.3 artemin IPO13 1p34.1 importin 13 DPH2L2 1p34 diptheria toxin resistance protein required for diphthamide biosynthesis-like 2 (S. cerevisiae) ATP6V0B 1p32.3 ATPase, H+ transporting, lysosomal 21kDa, V0 subunit c'' B4GALT2 1p34-p33 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 MGC45441 1p34.1 hypothetical protein MGC45441 SLC6A9 1p33 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 1697 - 499 - 1998 9682218
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine   highly
Reproductivefemale systemuteruscervix highly
 female systemovary  highly
cells
SystemCellPubmedSpeciesStageRna symbol
 proliferating cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text highly, in proliferating cells
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal peptide containing AAs 111-150 to bind MAD2L1
  • seven WD40-repeats
  • another MAD2L1-binding domain from AAs 342-355 within the WD repeat region
  • a unique polyhistidine motif with metal binding property adjacent to this second binding domain that may be important for maintaining the overall conformation of CDC20 for its binding to MAD2L1
  • CDC20/fizzy domain
  • two previously described motifs, the C box and the isoleucine-arginine (IR) tail, which are needed for CDC20 to bind to the APC/C as a coactivator
  • the KILR motif was necessary for CDC20 to bind to the APC/C when the spindle assembly checkpoint (SAC) was active
  • mono polymer heteromer , complex
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae CDC20p
    homolog to murine Cdc20 (94.6pc)
    Homologene
    FAMILY
  • WD repeat CDC20/Fizzy family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text enriched at the centrosome in neurons
    basic FUNCTION
  • involved in ubiquitin mediated proteolysis
  • mediating the association of the mitotic spindle checkpoint protein MAD1L1 with the cyclosome/anaphase-promoting complex (ANAPC/C)
  • required for microtubule dependant nuclear movement prior to anaphase and chromosomes sepration
  • is an essential ANPC/C activator
  • is involved in dendrite morphogenesis in postmitotic neurons
  • CDC20-ANPC regulates presynaptic differentiation in primary postmitotic mammalian neurons
  • activator of the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase, initiates the destruction of key mitotic regulators to facilitate mitosis, while it is negatively regulated by the spindle assembly checkpoint (SAC) to prevent premature anaphase entry
  • its transcriptional regulatory function was observed to be cell cycle-specific
  • orders passage through the meiotic divisions by ensuring a balance of phosphatases
  • co-activator of the anaphase-promoting complex/cyclosome (APC/C complex), which recruits substrates at particular phases of the cell cycle and mediates their degradation
  • is involved the degradation of SP100 and this process requires the D-box module
  • MAD2L1 competes directly for CDC20 with the anaphase-promoting complex/cyclosome (APC/C), which would contribute to the rapid and potent inhibition of CDC20
  • MAD2L1 is one of the key components of the spindle and mitotic checkpoint complex that regulates the fidelity of cell division along with MAD1L1, CDC20, BUB1B
  • CELLULAR PROCESS cell cycle, division, mitosis
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming a complex with BUB1B
  • CDC20-ANAPC regulates presynaptic differentiation in primary postmitotic mammalian neurons
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • activating the anaphase promoting complex (APC/C)
  • SPATC1
  • interacting with HDAC6 that stimulates activity of CDC20-ANPC and drives the differentiation of neurons
  • NEUROD2 might be a target of CDC20-ANPC in the control of presynaptic development
  • interaction between HSF2 and the APC/C subunit CDC27 and coactivator CDC20 is enhanced by moderate heat stress, and the degradation of HSF2 is induced during the acute phase of the heat shock response
  • specifically targets E2F1 for degradation in early mitosis and reveal a novel mechanism for limiting free E2F1 levels in cells, failure of which may compromise cell survival and/or homeostasis
  • transcriptionally up-regulates UBE2C expression through its WD40 domain
  • BUB1B-dependent CDC20 proteasomal degradation in G0 phase is required for ciliogenesis
  • FBXW52 is a substrate of both PLK4 and CDC20, two established regulators of centriole duplication
  • binds to key mitotic substrates, targeting them for ubiquitin modification by the APC/C, ultimately resulting in their degradation
  • stable interaction of CDC20 with MAD2 is required to maintain spindle assembly checkpoint (SAC) signaling
  • PHF8 is regulated by CDC20 and plays an important role in the G2/M transition
  • switch from activation of the anaphase-promoting complex/cyclosome (APC/C) by CDC20 to CDH1 during anaphase is crucial for accurate mitosis
  • CHEK1 is required for the metaphase-anaphase transition via regulating the subcellular localization and the expression of CDC20 and MAD2L1
  • cell & other
    REGULATION
    inhibited by FBXO5
    RASSF1 (RASSF1 inhibits APC/C(Cdc20) function through its D-box motifs)
    repressed by TP53 (TP53 inhibits tumor cell growth through the indirect regulation of CDC20)
    Other is ubiquitinated by APC/C and degraded to maintain mitotic arrest
    polyubiquitinated by HDAC6
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in many types of malignancies and remarkably suppressed by ectopic introduction of TP53
    tumoral     --over  
    of CDC20 and MAD2L1 is related to poor prognosis of urothelial bladder cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    might be a good potential therapeutic target for a broad spectrum of human cancer
    ANIMAL & CELL MODELS