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FLASH GENE
Symbol CDC16 contributors: mct - updated : 11-08-2021
HGNC name CDC16 cell division cycle 16 homolog (S. cerevisiae)
HGNC id 1720
Location 13q34      Physical location : 115.000.361 - 115.038.150
Synonym name
  • anaphase-promoting complex, subunit 6
  • cyclosome subunit 6
  • Synonym symbol(s) HGNC17839, APC6, CUT9, ANAPC6, CDC16Hs
    DNA
    TYPE functioning gene
    STRUCTURE 37.83 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 2331 - 620 - 1997 9405394
    18 - 2328 - 619 - 1997 9405394
    17 - 2175 - 568 - 1997 9405394
    17 - 2276 - 526 - 1997 9405394
    19 - 2201 - 620 - 1997 9405394
    19 - 2198 - 619 - 1997 9405394
    18 - 2146 - 526 - 1997 9405394
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Cardiovascularheart    
    Digestiveliver    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    seven tetratricopeptide repeats (TPR)
    HOMOLOGY
    interspecies homolog to murine Cdc16
    homolog to Drosophila cdc16
    homolog to C.elegans emb-27
    homolog to yeast S.cerevisiae cdc16
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleoplasm
    text
  • strongly expressed in the nucleus, it was also expressed in the cytosol
  • basic FUNCTION
  • has an essential role in the metaphase to anaphase transition (involved in cyclin degradation)
  • CDC16 might be located in the upstream of YDJC and inhibit the action of YDJC on K8
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell life, proliferation/growth
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    text control of mitosis
    PATHWAY
    metabolism
    signaling
    a component
  • component of the anaphase promoting/cyclosome complex (APC/C) is a large E3 ubiquitin ligase containing at least ten different, evolutionarily conserved components
  • core component among the eight protein subunits of the anaphase-promoting complex (APC)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CDC26 stabilizes the structure of CDC16, a core TPR protein required for APC integrity
  • CDC26-CDC16 association involves an intermolecular TPR mimic composed of one helix from each protein
  • LATS1-mediated phosphorylation of the T7 residue of CDC26 disrupts its interaction with CDC16
  • YDJC binds to CDC16
  • CDC16 overexpression increased the ubiquitination of YDJC
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in esophageal squamous cell carcinomas and hepatocellular carcinoma
    tumoral     --over  
    in some cell lines
    tumoral     --over  
    associated with early and advanced stages, lymph nodes, distant metastases and risk factors such as H. pylori in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    suppression of YDJC or boosting of CDC16 interaction with YDJC might be a novel way to prevent progression of lung cancer
    ANIMAL & CELL MODELS