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FLASH GENE
Symbol CDC14A contributors: mct - updated : 01-07-2016
HGNC name CDC14 cell division cycle 14 homolog A (S. cerevisiae)
HGNC id 1718
Corresponding disease
DFNB105 deafness, autosomal recessive 105
Location 1p21.2      Physical location : 100.818.022 - 100.985.832
Synonym name
  • CDC10 (cell division cycle 10, S. cerevisiae, homolog)
  • EC.number 3.1.3.16 /3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 175.27 kb     16 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    DPYD 1p22 dihydropyrimidine dehydrogenase SNX7 1p21.2 sorting nexin 7 LOC388653 1 LOC388653 LOC391058 1 similar to 60S ribosomal protein L5 PRG1 10q22.1 proteoglycan 1, secretory granule PALMD 1p22-p21 palmdelphin LOC391059 1 similar to Stromal cell derived factor receptor 2 AGL 1p21 amylo-1, 6-glucosidase, 4-alpha-glucanotransferase (glycogen debranching enzyme, glycogen storage disease type III) SLC35A3 1p21 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 HIAT1 1p21.3 hippocampus abundant transcript 1 DKFZp761A078 1p21.3 hypothetical protein DKFZp761A078 FLJ10287 1pter-q31.3 hypothetical protein FLJ10287 MGC14816 1p21.3 hypothetical protein MGC14816 DBT 1p31 dihydrolipoamide branched chain transacylase (E2 component of branched chain keto acid dehydrogenase complex; maple syrup urine disease) RTCD1 1p21.1 RTC domain containing 1 CDC14A 1p22 CDC14 cell division cycle 14 homolog A (S. cerevisiae) GPR88 1p21.3 G-protein coupled receptor 88 LOC391060 1 similar to 60S ribosomal protein L7a (Surfeit locus protein 3) (PLA-X polypeptide) LOC391061 1 similar to large subunit ribosomal protein L36a VCAM1 1p21 vascular cell adhesion molecule 1 EXTL2 1p12-p11 exostoses (multiple)-like 2 SLC30A7 1p21.2 solute carrier family 30 (zinc transporter), member 7 CGI-30 1p21.2 CGI-30 protein FLJ20139 1p21.2 hypothetical protein FLJ20139 EDG1 1p21 endothelial differentiation, sphingolipid G-protein-coupled receptor, 1 LOC391062 1 similar to peptidylprolyl isomerase A (cyclophilin A) LOC388654 1 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) OLFM3 1p22-p21 olfactomedin 3 HEJ1 1p22 olfactomedin 3 COL11A1 1p21 collagen, type XI, alpha 1 LOC388655 1 LOC388655
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 4287 66 594 - 2016 27259055
  • variant A1
  • distinct 3' terminal region and 3' UIR
  • 15 - 2453 - 623 - 2016 27259055
    distinct 3' terminal region and 3' UIR
    11 - 2544 - 383 - 2016 27259055
    15 - 2085 - 565 - 2016 27259055
    17 - 4411 - 610 - 2016 27259055
    14 - 2365 - 330 - 2016 27259055
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrineparathyroid   highly
    Hearing/Equilibriumearinnercochlea   Homo sapiens
    Lymphoid/Immunethymus   highly
    Reproductivemale systemtestis  highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Hearing / Equilibriumcochlea cell Homo sapiens
    Hearing / Equilibriumhair cell receptor Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae Cdc 14
    intraspecies homolog to PTEN
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleoplasm
    text
  • dynamically localizes to interphase but not mitotic centrosomes
  • located at the centrosomes during interphase
  • basic FUNCTION
  • dual specificity serine/threonine-tyrosine phosphatase, involved in cell cycle function and in tumorigenesis
  • involved in the exit of cell mitosis and initiation of DNA replication
  • its upregulation prevents targeting of exocyst and SNARE complexes to the midbody, both essential for abscission to occur 5)
  • CDC14A phosphatase prevents premature activation of CDK1 regulating CDC25A and CDC25B at the entry into mitosis 3)
  • down-regulates CDC25 activity at the G2/M transition to prevent premature activation of CDK1-Cyclin B1 complexes and untimely entry into mitosis
  • CDC14A phosphatase plays a role in cell cycle control in higher eukaryotes
  • play a role in the regulation of the centrosome cycle, mitosis, and cytokinesis, thereby influencing chromosome partitioning and genomic stability in cells
  • counteracts CDK1-cyclin B1 activity through WEE1 dephosphorylation
  • redundancy between CDC14B and CDC14A in DNA Double-Strand Break Repair repair
  • role for CDC14A in cell migration and adhesion that is clearly distinct from the mitotic and cytokinesis functions of Cdc14/Flp1 in budding and fission yeast
  • is the second DFNB gene reported to be involved in the control of kinocilium growth
  • CELLULAR PROCESS cell cycle
    cell life, proliferation/growth
    nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TP53
  • impacts the emerging signaling pathway between MAPK4 and MK5, a MAPK-activated protein kinase
  • CDC14A plays an important role in the regulation of WEE1 stability
  • CDC14A counteracts CDK1-CCNB1 activity through WEE1 dephosphorylation
  • DAPK3 may be involved in the regulation of the cell cycle in human cells, by interacting with CDC14A
  • cell & other
    REGULATION
    Other regulated by BRAP (facilitates CDC14A Lys-63 linked ubiquitin modification) (Chen 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNB105
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS