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FLASH GENE

Symbol

CDAN1

contributors: mct - updated : 14-01-2011

HGNC name	congenital dyserythropoietic anemia, type I
HGNC id	1713

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	CDAN1 congenital dyserythropoietic anemia, type I
Location	15q15.2      Physical location : 43.015.761 - 43.029.417
Synonym name	codanin 1
	discs lost homolog
Synonym symbol(s)	CDA1, CDAI, CDA-I, PRO1295, codanin, DLT

DNA

TYPE	functioning gene
STRUCTURE	13.66 kb     28 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site   transcription factor
text structure	proximal CDAN1 gene promoter region, containing five putative E2F binding sites,found to be a direct target of E2F1

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_138477 28 - 4757 NP_612486 - 1227 - 2002 12434312

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system ovary

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic erythroid

cell lineage

cell lines

fluid/secretion

at STAGE

cell cycle

cell cycle, interphase, S

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal 150 aa domain with sequence similarity to collagens
	two shorter segments that show weak similarities to the microtubule-associated proteins MAP1B and synapsin (SYN1)

HOMOLOGY

interspecies	ortholog to murine Cdan1
	ortholog to Dosophila cell survival gene discs lost encoding a cytoplasmic codanin-1-like protein

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,nucleus,chromatin/chromosome,heterochromosome
text	localized to heterochromatin in interphase cells
	at mitosis, underwent phosphorylation, which coincided with its exclusion from condensed chromosomes

basic FUNCTION	may be involved in nuclear envelope integrity, conceivably related to microtubule attachments
	cell cycle-regulated protein active in the S phase

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CDAN1

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS