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FLASH GENE
Symbol CDAN1 contributors: mct - updated : 14-01-2011
HGNC name congenital dyserythropoietic anemia, type I
HGNC id 1713
Corresponding disease
CDAN1 congenital dyserythropoietic anemia, type I
Location 15q15.2      Physical location : 43.015.761 - 43.029.417
Synonym name
  • codanin 1
  • discs lost homolog
  • Synonym symbol(s) CDA1, CDAI, CDA-I, PRO1295, codanin, DLT
    DNA
    TYPE functioning gene
    STRUCTURE 13.66 kb     28 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure proximal CDAN1 gene promoter region, containing five putative E2F binding sites,found to be a direct target of E2F1
    MAPPING cloned Y linked N status provisional
    Physical map
    MAPKBP1 15q14 likely ortholog of mouse mitogen activated protein kinase binding proten 1 PLA2G4B 15q11.2-q21.3 phospholipase A2, group IVB (cytosolic) SPTBN5 15q21 spectrin, beta, non-erythrocytic 5 EHD4 15q11.1-q15 EH-domain containing 4 FLJ45651 15q14 FLJ45651 protein LOC388117 15 LOC388117 cPLA2delta LOC255189 15q14 hypothetical protein LOC255189 VPS39 15q14-q15 vacuolar protein sorting 39 (yeast) DKFZP564G2022 15q14 DKFZP564G2022 protein GANC 15q15.1-q15.2 glucosidase, alpha; neutral C CAPN3 15q15.1-q15.3 calpain 3, (p94) ZFP106 15q14 zinc finger protein 106 homolog (mouse) SNAP23 15q14-q15.1 synaptosomal-associated protein, 23kDa FLJ36812 15q14 hypothetical protein FLJ36812 FLJ10460 15q14 hypothetical protein FLJ10460 LOC390579 15 similar to myosin regulatory light chain-like LOC388118 15 similar to kinesin-like protein STARD9 15q14 START domain containing 9 CDAN1 15q14-q15 congenital dyserythropoietic anemia, type I TTBK2 15q14 tau tubulin kinase 2 LOC390580 15 similar to Ac2-125 UBR1 15q15-q21.1 ubiquitin protein ligase E3 component n-recognin 1 LOC146053 15q14 similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1 LOC255320 15q15.1 similar to Microsomal signal peptidase 25 kDa subunit (SPase 25 kDa subunit) (SPC25) FLJ23375 15q15.1 hypothetical protein FLJ23375 CCNDBP1 15q14-q15 cyclin D-type binding-protein 1 EPB42 15q15 erythrocyte membrane protein band 4.2 TGM5 15q15.2 transglutaminase 5 LOC390581 15 similar to ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d; ATP synthase, H+ transporting, mitochondrial F1F0, subunit d TGM7 15q15.2 similar to ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d; ATP synthase, H+ transporting, mitochondrial F1F0, subunit d LCMT2 15q14 leucine carboxyl methyltransferase 2 LOC161823 15q15.1 similar to Adenosine deaminase CG11994-PA FLJ35867 15q15.1 hypothetical protein FLJ35867 76P 15q15 gamma tubulin ring complex protein (76p gene) TP53BP1 15q15-q21 tumor protein p53 binding protein, 1 MAP1A 15q13-qter microtubule-associated protein 1A KIAA0377 15q15-q21.2 microtubule-associated protein 1A CKMT1 15q15 creatine kinase, mitochondrial 1 (ubiquitous) STRC 15q15.3 stereocilin CATSPER2 15q13-q15 cation channel, sperm associated 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    28 - 4757 - 1227 - 2002 12434312
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerythroid
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, interphase, S
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal 150 aa domain with sequence similarity to collagens
  • two shorter segments that show weak similarities to the microtubule-associated proteins MAP1B and synapsin (SYN1)
  • HOMOLOGY
    interspecies ortholog to murine Cdan1
    ortholog to Dosophila cell survival gene discs lost encoding a cytoplasmic codanin-1-like protein
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus,chromatin/chromosome,heterochromosome
    text
  • localized to heterochromatin in interphase cells
  • at mitosis, underwent phosphorylation, which coincided with its exclusion from condensed chromosomes
  • basic FUNCTION
  • may be involved in nuclear envelope integrity, conceivably related to microtubule attachments
  • cell cycle-regulated protein active in the S phase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDAN1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS