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FLASH GENE
Symbol CDA contributors: mct/npt - updated : 28-02-2009
HGNC name cytidine deaminase
HGNC id 1712
Location 1p36.12      Physical location : 20.915.443 - 20.945.398
Synonym name
  • small cytidine deaminase
  • cytidine aminohydrolase
  • cytosine nucleoside deaminase
  • Synonym symbol(s) CDD, HCD
    EC.number 3.5.4.5
    DNA
    TYPE functioning gene
    SPECIAL FEATURE gene in gene, antisens
    text containing antisense sequences in their 5' utr
    STRUCTURE 29.96 kb     4 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    motif
    text structure binding sites for several transcription factors regulating CDA expression
    MAPPING cloned Y linked N status inconsistent : contradictory evidence
    Map pter - D1S2547 - D1S2607 - CDA - D1S1269 - D1S1376 - cen
    Physical map
    KIAA0090 1p36.13 ubiquitin specific protease 31 C1orf33 1p36.13 chromosome 1 open reading frame 33 AFAR3  aflatoxin B1 aldehyde reductase 3 AKR7A3 1p35.1-p36.23 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) AKR7A2 1p36.1-p35 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) FLJ20320 CAPZB 1p36.1 capping protein (actin filament) muscle Z-line, beta LOC388600 1 similar to protein of fungal metazoan origin like (11.1 kD) (2C514) NBL1 1p36.13-p36.11 neuroblastoma, suppression of tumorigenicity 1 HTR6 1p36-p35 5-hydroxytryptamine (serotonin) receptor 6 LOC255104 1p36.13 hypothetical protein LOC255104 FLJ20225 1p36.13 hypothetical protein FLJ20225 LOC254897 1p36.13 similar to OSJNBa0043A12.32 PLA2G2E 1p36.13 similar to OSJNBa0043A12.32 PLA2G2A 1p36.1-p35 phospholipase A2, group IIA (platelets, synovial fluid) PLA2G5 1p36-p34 phospholipase A2, group V PLA2G2D 1p36.12 phospholipase A2, group IID PLA2G2F 1p35 phospholipase A2, group IID LOC391013 1 similar to Group IIC secretory phospholipase A2 precursor (Phosphatidylcholine 2-acylhydrolase GIIC) (GIIC sPLA2) (PLA2-8) (14 kDa phospholipase A2) FLJ25429 FLJ32784 1p36.13 hypothetical protein FLJ32784 LOC388601 1 LOC388601 CaMKIINalpha 1p36.13 calcium/calmodulin-dependent protein kinase II FLJ12875 1p36.13 hypothetical protein FLJ12875 LOC163933 1p36.12 similar to cDNA sequence BC022623 CDA 1p36.2-p35 cytidine deaminase PINK1 1p36 PTEN induced putative kinase 1 DDOST 1p36.1 dolichyl-diphosphooligosaccharide-protein glycosyltransferase KIF17 1p36.13 kinesin family member 17 LOC388602 1 LOC388602 LOC388603 1 LOC388603 HP1-BP74 1p36.12 HP1-BP74 EIF4G3 11p15 eukaryotic translation initiation factor 4 gamma, 3 LOC388604 1 LOC388604 ECE1 1p36.1 endothelin converting enzyme 1 LOC391014 1 similar to protein phosphatase 1, regulatory (inhibitor) subunit 11 isoform 1; hemochromatosis candidate gene V; t-complex-associated-testis-expressed 5; inhibitor-3 LOC343381 1p36.12 similar to KIAA0454 protein LOC391015 1 similar to hypothetical protein AE2 LOC388605 1 similar to heparan-sulfate 6-sulfotransferase LOC391016 1 similar to KIAA0445 protein AE2 1p36.12 hypothetical protein AE2 ALPL 1p36.1 alkaline phosphatase, liver/bone/kidney RAP1GA1 1p36.1 RAP1, GTPase activating protein 1 USP31 1p36.12 ubiquitin specific protease 31 HSPG2 1p36.11-p35 heparan sulfate proteoglycan 2 (perlecan)
    RNA
    TRANSCRIPTS type messenger
    text two types of transcripts.Multiple minor transcripts diffring by their initiation site (Demontis)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 985 - 146 - Kuhn, Lisboa (2007)
    2 splicing 550 9.8 - - Lisboa (2007)
  • also called HSCD
  • exons 1 and 4 should be joined and all sequences of introns and exons 2 and 3 should be deleted by splicing
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Lymphoid/Immunespleen   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivecartilage   
    cells
    SystemCellPubmedSpeciesStageRna symbol
     chondrocyte
     fibroblast
    Blood/Hematopoieticgranulocyte
    Blood/Hematopoieticmonocyte
    cell lineage
    cell lines nucleotide cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a catalytically important zinc finger domain
  • mono polymer homomer , tetramer
    HOMOLOGY
    interspecies homolog to rattus Rn.6887
    homolog to C.elegans C47D2.2
    homolog to murine 2210401N16Rik
    Homologene
    FAMILY
  • cytidine and deoxycytidylate deaminases family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • catalyzes the deamination of cytidine or deoxycytidine to uridine or deoxyuridine, respectively (Lisboa 2007)
  • scavenging exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
  • deaminating and irreversibly deactivating the chemotherapeutic agent cytosine arabinoside (Ara-C), a deoxycytidine analog used for treatment of acute leukemias and lymphomas
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    nucleotides and nucleic acid metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS