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FLASH GENE
Symbol CDA contributors: mct/npt - updated : 28-02-2009
HGNC name cytidine deaminase
HGNC id 1712
Location 1p36.12      Physical location : 20.915.443 - 20.945.398
Synonym name
  • small cytidine deaminase
  • cytidine aminohydrolase
  • cytosine nucleoside deaminase
  • Synonym symbol(s) CDD, HCD
    EC.number 3.5.4.5
    DNA
    TYPE functioning gene
    SPECIAL FEATURE gene in gene, antisens
    text containing antisense sequences in their 5' utr
    STRUCTURE 29.96 kb     4 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    motif
    text structure binding sites for several transcription factors regulating CDA expression
    MAPPING cloned Y linked N status inconsistent : contradictory evidence
    Map pter - D1S2547 - D1S2607 - CDA - D1S1269 - D1S1376 - cen
    RNA
    TRANSCRIPTS type messenger
    text two types of transcripts.Multiple minor transcripts diffring by their initiation site (Demontis)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 985 - 146 - Kuhn, Lisboa (2007)
    2 splicing 550 9.8 - - Lisboa (2007)
  • also called HSCD
  • exons 1 and 4 should be joined and all sequences of introns and exons 2 and 3 should be deleted by splicing
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Lymphoid/Immunespleen   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivecartilage   
    cells
    SystemCellPubmedSpeciesStageRna symbol
     chondrocyte
     fibroblast
    Blood/Hematopoieticgranulocyte
    Blood/Hematopoieticmonocyte
    cell lineage
    cell lines nucleotide cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a catalytically important zinc finger domain
  • mono polymer homomer , tetramer
    HOMOLOGY
    interspecies homolog to rattus Rn.6887
    homolog to C.elegans C47D2.2
    homolog to murine 2210401N16Rik
    Homologene
    FAMILY
  • cytidine and deoxycytidylate deaminases family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • catalyzes the deamination of cytidine or deoxycytidine to uridine or deoxyuridine, respectively (Lisboa 2007)
  • scavenging exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
  • deaminating and irreversibly deactivating the chemotherapeutic agent cytosine arabinoside (Ara-C), a deoxycytidine analog used for treatment of acute leukemias and lymphomas
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    nucleotides and nucleic acid metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS