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FLASH GENE
Symbol CD99L2 contributors: mct - updated : 18-02-2016
HGNC name CD99 antigen-like 2
HGNC id 18237
Location Xq28      Physical location : 149.934.809 - 150.067.289
Synonym name MIC2 like 1
Synonym symbol(s) CD99B, MIC2L1, DKFZp761H2024
DNA
TYPE functioning gene
STRUCTURE 132.48 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
IDS Xq27.3-q28 iduronate 2-sulfatase (Hunter syndrome) IDSP1 Xq28 iduronate 2-sulfatase pseudogene 1 LOC91966 Xq28 hypothetical protein LOC91966 LOC347512 Xq28 similar to Heat shock transcription factor, Y-linked (Heat shock transcription factor 2-like protein) (HSF2-like) LW-1 Xq28 similar to Heat shock transcription factor, Y-linked (Heat shock transcription factor 2-like protein) (HSF2-like) FAM11A Xq28 similar to Heat shock transcription factor, Y-linked (Heat shock transcription factor 2-like protein) (HSF2-like) LOC392556 X similar to Melanoma-associated antigen 11 (MAGE-11 antigen) MAGEA11 Xq28 melanoma antigen, family A, 11 MAGEA9 Xq28 melanoma antigen, family A, 9 MAGEA7 Xq28 melanoma antigen, family A, 7, pseudogene MAGEA8 Xq28 melanoma antigen, family A, 8 LOC389900 X similar to DKFZP586L0724 protein LOC389901 X similar to ATP-dependent DNA helicase II, 70 kDa subunit (Lupus Ku autoantigen protein p70) (Ku70) (70 kDa subunit of Ku antigen) (Thyroid-lupus autoantigen) (TLAA) (CTC box binding factor 75 kDa subunit) (CTCBF) (CTC75) CXorf6 Xq28 chromosome X open reading frame 6 MTM1 Xq28 myotubular myopathy 1 MTMR1 Xq28 myotubularin related protein 1 CD99L2 Xq28 CD99 antigen-like 2 HMGB3 Xq28 high-mobility group box 3 LOC392557 X similar to hypothetical protein GPR50 Xq28 G protein-coupled receptor 50 LOC286456 Xq28 similar to NGFI-A binding protein 1; NGFI-A-binding protein 1; EGR1 binding protein 1 LOC139135 Xq28 hypothetical protein LOC139135 TMG3 Xq28 transmembrane gamma-carboxyglutamic acid protein 3 FATE Xq28 transmembrane gamma-carboxyglutamic acid protein 3 LOC389902 X similar to Cyclic-nucleotide-gated olfactory channel (Cyclic-nucleotide-gated cation channel 2) (CNG channel 2) (CNG-2) (CNG2) (Aorta CNG channel) (RACNG) MAGEA4 Xq28 melanoma antigen, family A, 4 GABRE Xq28 gamma-aminobutyric acid (GABA) A receptor, epsilon LOC392558 X similar to 33K laminin receptor homolog - bovine MAGEA5 Xq28 melanoma antigen, family A, 5 MAGEA10 Xq28 melanoma antigen, family A, 10 GABRA3 Xq28 gamma-aminobutyric acid (GABA) A receptor, alpha 3 GABRQ Xq28 gamma-aminobutyric acid (GABA) receptor, theta TRAG3 Xq28 taxol resistance associated gene 3 MAGEA2b Xq28 melanoma antigen, family A, 2, copy b MAGEA12 Xq28 melanoma antigen, family A, 12 CSAGE Xq28 chondrosarcoma associated gene 1 MAGEA2 Xq28 melanoma antigen, family A, 2 LOC389903 X similar to Taxol resistant associated protein 3 (TRAG-3)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 3736 - 262 - 2003 12706889
9 - 3589 - 213 - 2003 12706889
8 - 3520 - 190 - 2003 12706889
9 - 3517 - 189 - 2003 12706889
12 - 3754 - 272 - 2003 12706889
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
Cardiovascularheart   moderately
Digestiveliver   moderately
Endocrinepancreas   highly
Nervousbrain   highly
Reproductivemale systemprostate  moderately
Respiratorylung   moderately
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Epithelialsecretoryglandularendocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte Homo sapiens
Cardiovascularendothelial cell Homo sapiens
Lymphoid/Immunelymphocyte Homo sapiens
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies ortholog to murine Mic2l1
ortholog to murine CD99
intraspecies paralog to CD99
Homologene
FAMILY
CATEGORY antigen
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
    intracellular
intracellular,cytoplasm,organelle,mitochondria
intracellular,cytoplasm,organelle,membrane
basic FUNCTION
  • CD99 and CD99L2 act independently of PECAM1 in leukocyte extravasation and cooperate in an independent way to help neutrophils overcome the endothelial basement membrane
  • is an essential endothelial Ag for leukocyte extravasation, which does not require homophilic interactions with CD99L2 on leukocytes
  • play likely a role in leukocyte extravasation under various inflammatory conditions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking CD99L2 had a defective inflammatory response in the thioglycollate peritonitis model with a greater than 80p100 block in neutrophil infiltration and a nearly complete block in monocyte emigration into the peritoneal cavity