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FLASH GENE

Symbol

CD97

contributors: mct - updated : 20-10-2012

HGNC name	CD97 molecule
HGNC id	1711

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.12      Physical location : 14.492.212 - 14.519.533
Synonym name	cell differentiation antigen CD97 identified by monoclonal antibodies BL-Ac/F2, VIM3, VIM3B, VIM3C
	heterodimeric receptor associated with inflammation
	leukocyte antigen CD97
	seven transmembrane helix receptor
Synonym symbol(s)	TM7LN1

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster, opposite orientation
text	in opposite direction with EMR2
	clustered with EMRs (1, 2, 3 or 4)
STRUCTURE	27.58 kb     24 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	cytosine-phosphate-guanine/HTF
	Binding site   transcription factor
text structure	TATA box-lacking promoter possesses several GC-rich regions as putative Sp1/Sp3 binding sites, and activity of CD97 promoter which is controlled by Sp1/Sp3 transcription factors in smooth muscle cells

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_078481 24 splicing 3500 NP_510966 91.9 835 - 2007 17056209 four EGF-like domains one GPS domain possible suppressive properties in gastric carcinoma NM_001784 18 splicing 3221 NP_001775 81.7 742 - 2010 20428763 lacking exons 5 and 6 two EGF-like domains tumor promoting role of CD97 small isoform in cancer progression NM_001025160 19 splicing 3353 NP_001020331 86.6 786 - 2007 17056209 two EGF-like domains Variant 4 - splicing - Variant 4 - - - 2007 17056209 three EGF-like domains lacking the seven transmebmrane region (7TM) lacking the GPS domain coding for a non-fonctional product

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       moderately   stomach       highly Lymphoid/Immune spleen       highly   thymus       highly Nervous brain       moderately Reproductive female system uterus cervix   highly   male system prostate     moderately Respiratory lung       moderately Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular smooth       Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Lymphoid/Immune activated leukocyte Lymphoid/Immune macrophage

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains	four tandem EGF-like domains
	two of them with calcium-binding sites
	a single RGD motif, including several potential N and O glycosylation sites, coupled to a seven-span transmembrane segment (7TM) by a mucin-like spacer domain (site-specific N-glycosylation is an important determinant of (GPCR) proteolytic site proteolysis)

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to murine Cd97
	homolog to rattus Rn.7386
	homolog to C.elegans F09A5.2

Homologene

FAMILY	G-protein coupled receptor 2 family
	secretin-receptor superfamily
	EGF-TM7 family of class II seven-span transmembrane (7-TM) molecules

CATEGORY

adhesion , antigen , receptor membrane G

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION	acting as a receptor potentially involved in both adhesion and signaling processes early after leucocyte activation
	shows different features of expression and function in muscle cells compared to hematopoetic and tumor cells
	is induced in multiple epithelial cancer lineages
	plays an important role in tumor aggressiveness by binding its cellular ligand CD55
	CD97 and CD55 both play important roles in tumor dedifferentiation, migration, invasiveness, and metastasis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense , inflammation

PATHWAY

metabolism

signaling

signal transduction

a component

CD97 heterodimerized and functionally synergized with LPAR1, a GPCR implicated in cancer progression

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+

protein	binding to CD95, decay accelerating factor (DAF,CD55)
	CD97 functioned to mediate invasion in prostate cancer cells, at least in part, by associating with lysophosphatidic acid receptor 1 (LPAR1)
	CD97, present on peripheral myeloid cells, is a novel interacting partner for THY1 (is an interacting partner for CD97 on activated endothelial cells)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in gastrointestinal carcinomas tumoral     --over   in primary gallbladder carcinoma constitutional     --over   on polymorphonuclear cells (PMNC) of patients with psoriasis tumoral     --over   of CD97 and its ligand CD55 at the invasion front correlate with rectal tumor recurrence and metastasis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive prostate potential therapeutic cancer target

ANIMAL & CELL MODELS