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FLASH GENE
Symbol CD97 contributors: mct - updated : 20-10-2012
HGNC name CD97 molecule
HGNC id 1711
Location 19p13.12      Physical location : 14.492.212 - 14.519.533
Synonym name
  • cell differentiation antigen CD97 identified by monoclonal antibodies BL-Ac/F2, VIM3, VIM3B, VIM3C
  • heterodimeric receptor associated with inflammation
  • leukocyte antigen CD97
  • seven transmembrane helix receptor
    • Synonym symbol(s) TM7LN1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster, opposite orientation
    text
  • in opposite direction with EMR2
  • clustered with EMRs (1, 2, 3 or 4)
    • STRUCTURE 27.58 kb     24 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    Binding site   transcription factor
    text structure
  • TATA box-lacking promoter possesses several GC-rich regions as putative Sp1/Sp3 binding sites, and activity of CD97 promoter which is controlled by Sp1/Sp3 transcription factors in smooth muscle cells
    • MAPPING cloned Y linked N status confirmed
    Physical map
    ZSWIM4 19p13.13 zinc finger, SWIM domain containing 4 NANOS3 19p13.13 nanos homolog 3 (Drosophila) MGC11271 19p13.13 hypothetical protein MGC11271 FLJ20241 19p13.13 putative NFkB activating protein FLJ23447 19p13.13 hypothetical protein FLJ23447 LOC90379 19p13.13 hypothetical protein BC002926 RFX1 19p13.1 regulatory factor X, 1 (influences HLA class II expression) RLN3 19p13.2 relaxin 3 (H3) WSX1 LOC342979 19p13.13 hypothetical LOC342979 LOC126037 19p13.13 similar to eukaryotic translation elongation factor 1 delta isoform 1; guanine nucleotide exchange protein LOC113230 19p13.13 hypothetical protein LOC113230 PRKACA 19p13.1 protein kinase, cAMP-dependent, catalytic, alpha ASF1B 19p13.12 ASF1 anti-silencing function 1 homolog B (S. cerevisiae) LPHN1 19p13.2 latrophilin 1 CD97 19p13.2-p13.12 CD97 antigen DDX39 19p13.13 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39 PRKCL1 19p13.1-p12 protein kinase C-like 1 PTGER1 19p13.1 prostaglandin E receptor 1 (subtype EP1), 42kDa RGS19IP1 19p13.2-p13.1 regulator of G-protein signalling 19 interacting protein 1 DNAJB1 19p13.2 DnaJ (Hsp40) homolog, subfmaily B, member 1 GPSN2 19p13.12 glycoprotein, synaptic 2 NDUFB7 19p13.12-p13.11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa LOC388512 19 similar to Asialoglycoprotein receptor 2 (Hepatic lectin H2) (ASGP-R) (ASGPR) EMR3 19p13.1 egf-like module containing, mucin-like, hormone receptor-like 3 ZNF333 19p13 zinc finger protein 333 EMR2 19p13.1 egf-like module containing, mucin-like, hormone receptor-like sequence 2 OR7C1 19p13.1 olfactory receptor, family 7, subfamily C, member 1 OR7A5 19p13.1 olfactory receptor, family 7, subfamily A, member 5 pseudogene LOC390892 19 similar to Olfactory receptor 7A10 (OST027) LOC390893 19 similar to Olfactory receptor 7A10 (OST027) LOC390894 19 similar to Olfactory receptor 7A2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    24 splicing 3500 91.9 835 - 2007 17056209
  • four EGF-like domains
  • one GPS domain
  • possible suppressive properties in gastric carcinoma
    • 18 splicing 3221 81.7 742 - 2010 20428763
  • lacking exons 5 and 6
  • two EGF-like domains
  • tumor promoting role of CD97 small isoform in cancer progression
    • 19 splicing 3353 86.6 786 - 2007 17056209
  • two EGF-like domains
    • - splicing - - - - 2007 17056209
  • three EGF-like domains
  • lacking the seven transmebmrane region (7TM)
  • lacking the GPS domain
  • coding for a non-fonctional product
    		•
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   moderately
     stomach   highly
    Lymphoid/Immunespleen   highly
     thymus   highly
    Nervousbrain   moderately
    Reproductivefemale systemuteruscervix highly
     male systemprostate  moderately
    Respiratorylung   moderately
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularsmooth   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Lymphoid/Immuneactivated leukocyte
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • four tandem EGF-like domains
  • two of them with calcium-binding sites
  • a single RGD motif, including several potential N and O glycosylation sites, coupled to a seven-span transmembrane segment (7TM) by a mucin-like spacer domain (site-specific N-glycosylation is an important determinant of (GPCR) proteolytic site proteolysis)
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Cd97
    homolog to rattus Rn.7386
    homolog to C.elegans F09A5.2
    Homologene
    FAMILY
  • G-protein coupled receptor 2 family
  • secretin-receptor superfamily
  • EGF-TM7 family of class II seven-span transmembrane (7-TM) molecules
    • CATEGORY adhesion , antigen , receptor membrane G
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • acting as a receptor potentially involved in both adhesion and signaling processes early after leucocyte activation
  • shows different features of expression and function in muscle cells compared to hematopoetic and tumor cells
  • is induced in multiple epithelial cancer lineages
  • plays an important role in tumor aggressiveness by binding its cellular ligand CD55
  • CD97 and CD55 both play important roles in tumor dedifferentiation, migration, invasiveness, and metastasis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • CD97 heterodimerized and functionally synergized with LPAR1, a GPCR implicated in cancer progression
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • binding to CD95, decay accelerating factor (DAF,CD55)
  • CD97 functioned to mediate invasion in prostate cancer cells, at least in part, by associating with lysophosphatidic acid receptor 1 (LPAR1)
  • CD97, present on peripheral myeloid cells, is a novel interacting partner for THY1 (is an interacting partner for CD97 on activated endothelial cells)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastrointestinal carcinomas
    tumoral     --over  
    in primary gallbladder carcinoma
    constitutional     --over  
    on polymorphonuclear cells (PMNC) of patients with psoriasis
    tumoral     --over  
    of CD97 and its ligand CD55 at the invasion front correlate with rectal tumor recurrence and metastasis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    potential therapeutic cancer target
    ANIMAL & CELL MODELS