Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CD97 contributors: mct - updated : 20-10-2012
HGNC name CD97 molecule
HGNC id 1711
Location 19p13.12      Physical location : 14.492.212 - 14.519.533
Synonym name
  • cell differentiation antigen CD97 identified by monoclonal antibodies BL-Ac/F2, VIM3, VIM3B, VIM3C
  • heterodimeric receptor associated with inflammation
  • leukocyte antigen CD97
  • seven transmembrane helix receptor
  • Synonym symbol(s) TM7LN1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster, opposite orientation
    text
  • in opposite direction with EMR2
  • clustered with EMRs (1, 2, 3 or 4)
  • STRUCTURE 27.58 kb     24 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    Binding site   transcription factor
    text structure
  • TATA box-lacking promoter possesses several GC-rich regions as putative Sp1/Sp3 binding sites, and activity of CD97 promoter which is controlled by Sp1/Sp3 transcription factors in smooth muscle cells
  • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    24 splicing 3500 91.9 835 - 2007 17056209
  • four EGF-like domains
  • one GPS domain
  • possible suppressive properties in gastric carcinoma
  • 18 splicing 3221 81.7 742 - 2010 20428763
  • lacking exons 5 and 6
  • two EGF-like domains
  • tumor promoting role of CD97 small isoform in cancer progression
  • 19 splicing 3353 86.6 786 - 2007 17056209
  • two EGF-like domains
  • - splicing - - - - 2007 17056209
  • three EGF-like domains
  • lacking the seven transmebmrane region (7TM)
  • lacking the GPS domain
  • coding for a non-fonctional product
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   moderately
     stomach   highly
    Lymphoid/Immunespleen   highly
     thymus   highly
    Nervousbrain   moderately
    Reproductivefemale systemuteruscervix highly
     male systemprostate  moderately
    Respiratorylung   moderately
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularsmooth   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Lymphoid/Immuneactivated leukocyte
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • four tandem EGF-like domains
  • two of them with calcium-binding sites
  • a single RGD motif, including several potential N and O glycosylation sites, coupled to a seven-span transmembrane segment (7TM) by a mucin-like spacer domain (site-specific N-glycosylation is an important determinant of (GPCR) proteolytic site proteolysis)
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Cd97
    homolog to rattus Rn.7386
    homolog to C.elegans F09A5.2
    Homologene
    FAMILY
  • G-protein coupled receptor 2 family
  • secretin-receptor superfamily
  • EGF-TM7 family of class II seven-span transmembrane (7-TM) molecules
  • CATEGORY adhesion , antigen , receptor membrane G
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • acting as a receptor potentially involved in both adhesion and signaling processes early after leucocyte activation
  • shows different features of expression and function in muscle cells compared to hematopoetic and tumor cells
  • is induced in multiple epithelial cancer lineages
  • plays an important role in tumor aggressiveness by binding its cellular ligand CD55
  • CD97 and CD55 both play important roles in tumor dedifferentiation, migration, invasiveness, and metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • CD97 heterodimerized and functionally synergized with LPAR1, a GPCR implicated in cancer progression
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • binding to CD95, decay accelerating factor (DAF,CD55)
  • CD97 functioned to mediate invasion in prostate cancer cells, at least in part, by associating with lysophosphatidic acid receptor 1 (LPAR1)
  • CD97, present on peripheral myeloid cells, is a novel interacting partner for THY1 (is an interacting partner for CD97 on activated endothelial cells)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastrointestinal carcinomas
    tumoral     --over  
    in primary gallbladder carcinoma
    constitutional     --over  
    on polymorphonuclear cells (PMNC) of patients with psoriasis
    tumoral     --over  
    of CD97 and its ligand CD55 at the invasion front correlate with rectal tumor recurrence and metastasis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    potential therapeutic cancer target
    ANIMAL & CELL MODELS