Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CD96 contributors: mct/npt - updated : 03-01-2017
HGNC name CD96 molecule
HGNC id 16892
Corresponding disease
OTGC Opitz trigonocephaly, C syndrome
Location 3q13.13      Physical location : 111.260.925 - 111.371.205
Synonym name
  • CD96 antigen
  • T-cell surface protein tactile
  • cell activation, increased late expression
    • Synonym symbol(s) TACTILE, MGC22596, DKFZp667E2122
    DNA
    TYPE functioning gene
    STRUCTURE 110.28 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 4433 - 569 predominates in all the CD96-expressing cell types and tissues Wang, Fuchs, Meyer (2009)
  • a V-like (variant 2) second domain (Meyer 2009)
    • 15 - 5200 - 585 - Wang, Fuchs, Meyer (2009)
    an I-like (variant 1)domain (Meyer 2009)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    Lymphoid/Immunenatural killer
    Lymphoid/ImmuneT cell
    cell lineage activated B cells very lowly
    cell lines some transormed T cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two immunoglobulin-like V-type domains
  • an immunoglobulin-like C2 type domain
  • a signal peptide, an extracellular region with 15N-linked glycosylation sites
  • 132 residue stretch rich in serine, threonine, and proline, a characteristic of domains with extensive O-linked glycosylation
  • three extracellular immunoglobulin-like domains (Meyer 2009)
  • a membrane proximal region rich in proline/serine/threonine (Meyer 2009)
  • cytoplasmic tail containing a YXXM motif, a potential SH2 domain-binding site for the p85 subunit of the pl3 kinase frequently encountered in coreceptors of the Ig superfamily and involved in signaling (Meyer 2009)
    • conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
    • CATEGORY adhesion , immunity/defense , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION
  • playing a role in antigen presentation and/or lymphocyte activation
  • involved in adhesive interactions of activated T and NK cells during the late phase of the immune response
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text antipathogen response
    PATHWAY
    metabolism
    signaling
    a component
  • homodimer disulfide-linked
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with the poliovirus receptor, CD155, to recognize targets for natural killer (NK) cells
  • binds to CD155 (poliovirus receptor, PVR) and NECTIN1, an adhesion receptor related to PVR (interaction may be crucial in developmental processes) (Meyer 2009)
  • PVR engages the activating receptor CD226, the inhibitory receptor TIGIT, and the CD96 receptor with both activating and inhibitory functions
    • cell & other
    REGULATION
    induced by T cells activator (strongly upregulated after the activating stimulus-peacking 6 to 9 day after activation)
    ASSOCIATED DISORDERS
    corresponding disease(s) OTGC
    Susceptibility
    Variant & Polymorphism
    Candidate gene tumor marker for T-cell acute lymphoblastic leukemia and acute myeloid leukemia (Meyer 2009)
    Marker
    Therapy target
    ANIMAL & CELL MODELS