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FLASH GENE
Symbol CD93 contributors: mct - updated : 25-10-2017
HGNC name CD93 molecule
HGNC id 15855
Location 20p11.21      Physical location : 23.059.993 - 23.066.977
Synonym name
  • collectin receptor
  • complement component 1
  • q subcomponent, receptor 1
  • CD93 antigen
  • matrix-remodelling associated 4
  • C1q/MBL/SPA receptor
  • Synonym symbol(s) C1QRP, C1QR1, MXRA4, C1qR(P), dJ737E23.1, CDw93, ECSM3
    DNA
    TYPE functioning gene
    STRUCTURE 6.99 kb     2 Exon(s)    1 Copie(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 6701 66.4 652 - 1997 9047234
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet
    Cardiovascularendothelial cell
    Lymphoid/ImmuneB cell Homo sapiens
    cell lineage myeloid origin
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text placenta, umbilical cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N linked glycosylation site
  • lectin C type domain, a C-type carbohydrate recognition domain
  • five calcium binding EGF-like domain
  • carbohydrate recognition domain
  • 47 AA cytoplasmic tail with a potential tyrosine kinase phosphorylation site, containing a highly charged juxtamembrane domain of 15 AA shared with other adhesion molecules, such as CD43, CD44
  • a transmembrane domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine C1qr
    Homologene
    FAMILY C-type lectin domain containing group 14 family
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • modulating phagocytosis of suboptimally opsonized immunoglobulin G and complement particles in vitro
  • modulating phagocytosis of apoptotic cells in vivo
  • plays a role in C1q/MBL/SPA-mediated removal or destruction of pathogens and immune complexes by phagocytosis
  • involved in the C1q-mediated enhancement of phagocytosis in innate and adaptive immune responses
  • receptor expressed during early B-cell development, is reinduced during plasma-cell differentiation
  • crucial role in the maintenance of plasma cells in the bone marrow
  • play an important role in the regulation of the angiogenic process
  • CD93 mediates adhesion in the endothelium
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text C1qR(P) is a highly glycosylated transmembrane protein that is the human C1q receptor/receptor component that in vitro mediates enhancement of Fc- and C3b-mediated phagocytosis
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor for complement component 1, subcomponent q phagocytosis
  • binding of GIPC to the cytoplamic tail of CD93 involving a newly identified class I PDZ-binding domain in the CD93 carboxyl terminus
  • interact with the moesin protein, a member of the Ezrin/Radixin/Moesin family
  • MMRN2 pan-endothelial extracellular matrix protein, is a specific ligand for CD93 (
  • cell & other
  • O-glycosylation stabilazing cell surface expression of C1qRP/CD93
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS