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FLASH GENE
Symbol CD86 contributors: mct - updated : 24-10-2017
HGNC name CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
HGNC id 1705
Location 3q13.33      Physical location : 121.774.220 - 121.839.982
Genatlas name cell differentiation antigen CD86,identified by monoclonal antibody FUN1,B7.2
Synonym name
  • B lymphocyte activation antigen B7-2
  • CTLA-4 counter-receptor B7.2
  • Synonym symbol(s) CD28LG2, LAB72, B7.2, B70, MGC34413
    DNA
    TYPE functioning gene
    STRUCTURE 65.78 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • two GAS (gamma-interferon activating site) elements in the promoter region
  • methylation pattern in the CD86 promoter and CpG island is closely related to the expression of this co-stimulatory molecule in keratinocytes
  • MAPPING cloned Y linked   status confirmed
    Physical map
    LOC389143 3 LOC389143 GPR156 3q13.33 G protein-coupled receptor 156 LOC116064 3q13.33 hypothetical protein LOC116064 FSTL1 3q13.33 follistatin-like 1 NDUFB4 3q13.33 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa HGD 3q21-q23 homogentisate 1,2-dioxygenase (homogentisate oxidase) MGC23920 GTF2E1 3q21-q24 general transcription factor IIE, polypeptide 1, alpha 56kDa KIAA1006 3q13.33 general transcription factor IIE, polypeptide 1, alpha 56kDa POLQ 3q13.31 polymerase (DNA directed), theta LOC51725 3q21.1 muscle disease-related protein HCLS1 3q13 hematopoietic cell-specific Lyn substrate 1 GOLGB1 3q13 golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1 KIAA0036 3q21.1 golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1 EAF2 3q21.1 ELL associated factor 2 SLC15A2 3p14.3-p14.1 solute carrier family 15 (H+/peptide transporter), member 2 MGC50831 3q21.1 hypothetical protein MGC50831 CD86 3q21 CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) CASR 3q21-q24 calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism) LOC391570 3 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) CSTA 3q21 cystatin A (stefin A) LOC131076 3q21.1 hypothetical LOC131076 E2IG5 3q21.1 growth and transformation-dependent protein WDR5B 3q21.1 WD repeat domain 5B KPNA1 3q21 karyopherin alpha 1 (importin alpha 5) BAL 3q13-q21 B aggressive lymphoma gene LOC151636 FLJ40597 3q21.1 hypothetical protein FLJ40597 LOC339881 3q21.1 similar to eukaryotic initiation factor 4B KIAA1268 3q21.1 KIAA1268 protein HSPBAP1 3q21 HSPB (heat shock 27kDa) associated protein 1 DIRC2 3q21.1 disrupted in renal carcinoma 2 SEMA5B 3q21.1 sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B PDIR 3q21.1 for protein disulfide isomerase-related SEC22L2 3q21.1 SEC22 vesicle trafficking protein-like 2 (S. cerevisiae) ADCY5 3q13.2-q21 adenylate cyclase 5 PTPLB 3q21.1 protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b MYLK 3q21 myosin, light polypeptide kinase FLJ12892 3q21.2 hypothetical protein FLJ12892
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing initiation site 2790 - 323 - 2000 1102152
    alternate 5' utr exon 1
    7 splicing initiation site 2735 - 329 - 2000 1102152
    alternate 5' utr exon 2
    - - 2646 - 275 serum soluble 2000 1102152
  • CD86 delta TM
  • biologically active
  • 6 - 2399 - 217 - 2000 1102152
    6 - 2685 - 247 - 2000 1102152
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Lymphoid/Immunespleen   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Skin/Tegumentkeratinocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide
  • Ig variable-like (IgV) domains, Ig constant-like (IgC) domains and intracellular domains
  • a transmembrane domain (1TM) and a cytoplasmic domain
  • highly conserved polylysine motif in CD86 cytoplasmic tail, referred to as the K4 motif, is responsible for the constitutive association of CD86 to the cytoskeleton in primary antigen presenting cells (APC)
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY immunoglobulin superfamily, B7 family
    CATEGORY immunity/defense , antigen , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text type I membrane protein
    basic FUNCTION
  • costimulatory molecule for the priming and activation of na
  • ve and memory T cells, respectively
  • expression of CD86 on islet endothelial cells facilitates T cell adhesion and migration
  • direct signaling through CD86/CD80 is a potent regulator of IgG secretion by previously activated B cells
  • rapidly internalized in cells expressing MARCH1, leading to lysosome-dependent degradation
  • its ubiquitination appears to promote endocytosis and direct CD86 to lysosomes where it cannot be efficiently retrieved to the cell surface even when lysosomal degradation is inhibited
  • critical importance of the cytoskeleton-dependent CD86 polarization to the immunological synapse (IS) and more specifically the K4 motif for effective co-signaling
  • CD80/CD86 engagement results in DC production of the pro-inflammatory cytokine IL6, which is necessary for full T cell activation
  • expression levels of CD86 are tightly regulated, being actively decreased by regulatory T cells and increased in response to pathogen-derived signals
  • distinct but complementary roles of CD80 and CD86 IgV and IgC domains in T cell activation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IFNG
  • ligand of TCR antigen CD28
  • SPI1 is a critical factor for the expression of CD80 and CD86
  • ubiquitinated in dendritic cells via MARCH1 E3 ubiquitin ligase and that this ubiquitination plays a key role in CD86 regulation
  • CD86 is rapidly endocytosed in the presence of MARCH1 followed by lysosome-dependent degradation
  • CD86 ubiquitination by MARCH1 occurs post-endoplasmic reticulum
  • IL2 upregulates CD86 expression on human CD4(+) and CD8(+) T cells via a receptor-dependent mechanism that involves the NFATC1 and mammalian target of rapamycin pathways
  • PHB/PHB2 and the CD86 cytoplasmic domain cooperate to mediate CD86 signaling in a B cell through differential phosphorylation of distal signaling intermediates required to increase IGHG1
  • interaction of CD86, CD80 with appropriate receptors is essential for an effective T cell response
  • role for IL21 as an inducer of the costimulatory ligand CD86 on B lymphocytes
  • DEF103B induces the costimulatory molecule CD86 on primary monocytes by a mechanism involving autocrine activation of ionotropic P2RX7 by ATP
  • decreased CD1D is associated with CD86 over-expression in B cells from systemic lupus erythematosus
  • cell & other
    REGULATION
    induced by interferon gamma
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    or expressed aberrantly on immune cells in a wide array of autoimmune and infectious diseases
    constitutional     --low  
    of CD86 expression by transitional B-cells due to the autocrine effect of IL10, which in turn leads to decreased T-cell proliferation and TNF production
    Susceptibility to asthma
    Variant & Polymorphism other I179V polymorphism, may be a novel aetiological factor in the development of asthma and related allergic disorders
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS