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FLASH GENE
Symbol CD86 contributors: mct - updated : 14-11-2012
HGNC name CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
HGNC id 1705
Location 3q21      Physical location : 121.774.220 - 121.839.982
Genatlas name cell differentiation antigen CD86,identified by monoclonal antibody FUN1,B7.2
Synonym name
  • B lymphocyte activation antigen B7-2
  • CTLA-4 counter-receptor B7.2
  • Synonym symbol(s) CD28LG2, LAB72, B7.2, B70, MGC34413
    DNA
    TYPE functioning gene
    STRUCTURE 65.00 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure two GAS (gamma-interferon activating site) elements in the promoter region
    MAPPING cloned Y linked   status confirmed
    Physical map
    LOC389143 3 LOC389143 GPR156 3q13.33 G protein-coupled receptor 156 LOC116064 3q13.33 hypothetical protein LOC116064 FSTL1 3q13.33 follistatin-like 1 NDUFB4 3q13.33 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa HGD 3q21-q23 homogentisate 1,2-dioxygenase (homogentisate oxidase) MGC23920 GTF2E1 3q21-q24 general transcription factor IIE, polypeptide 1, alpha 56kDa KIAA1006 3q13.33 general transcription factor IIE, polypeptide 1, alpha 56kDa POLQ 3q13.31 polymerase (DNA directed), theta LOC51725 3q21.1 muscle disease-related protein HCLS1 3q13 hematopoietic cell-specific Lyn substrate 1 GOLGB1 3q13 golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1 KIAA0036 3q21.1 golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1 EAF2 3q21.1 ELL associated factor 2 SLC15A2 3p14.3-p14.1 solute carrier family 15 (H+/peptide transporter), member 2 MGC50831 3q21.1 hypothetical protein MGC50831 CD86 3q21 CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) CASR 3q21-q24 calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism) LOC391570 3 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) CSTA 3q21 cystatin A (stefin A) LOC131076 3q21.1 hypothetical LOC131076 E2IG5 3q21.1 growth and transformation-dependent protein WDR5B 3q21.1 WD repeat domain 5B KPNA1 3q21 karyopherin alpha 1 (importin alpha 5) BAL 3q13-q21 B aggressive lymphoma gene LOC151636 FLJ40597 3q21.1 hypothetical protein FLJ40597 LOC339881 3q21.1 similar to eukaryotic initiation factor 4B KIAA1268 3q21.1 KIAA1268 protein HSPBAP1 3q21 HSPB (heat shock 27kDa) associated protein 1 DIRC2 3q21.1 disrupted in renal carcinoma 2 SEMA5B 3q21.1 sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B PDIR 3q21.1 for protein disulfide isomerase-related SEC22L2 3q21.1 SEC22 vesicle trafficking protein-like 2 (S. cerevisiae) ADCY5 3q13.2-q21 adenylate cyclase 5 PTPLB 3q21.1 protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b MYLK 3q21 myosin, light polypeptide kinase FLJ12892 3q21.2 hypothetical protein FLJ12892
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing initiation site 2797 - 323 - Jellis, Ortiz-Sánchez
    alternate 5' utr exon 1
    - splicing initiation site 2748 - 329 - Jellis, Ortiz-Sánchez
    alternate 5' utr exon 2
    - - - - - serum soluble Jeannin
    biologically active
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Lymphoid/Immunespleen   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide
  • an IgV
  • an IgC-like domains
  • a transmembrane domain (1TM) and a cytoplasmic domain
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY immunoglobulin superfamily
    CATEGORY immunity/defense , antigen , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION
  • costimulatory molecule for the priming and activation of na
  • ve and memory T cells, respectively
  • rapidly internalized in cells expressing MARCH1, leading to lysosome-dependent degradation
  • its ubiquitination appears to promote endocytosis and direct CD86 to lysosomes where it cannot be efficiently retrieved to the cell surface even when lysosomal degradation is inhibited
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IFNG
  • ligand of TCR antigen CD28
  • ubiquitinated in dendritic cells via MARCH1 E3 ubiquitin ligase and that this ubiquitination plays a key role in CD86 regulation
  • CD86 is rapidly endocytosed in the presence of MARCH1 followed by lysosome-dependent degradation
  • CD86 ubiquitination by MARCH1 occurs post-endoplasmic reticulum
  • cell & other
    REGULATION
    induced by interferon gamma
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    or expressed aberrantly on immune cells in a wide array of autoimmune and infectious diseases
    Susceptibility to asthma
    Variant & Polymorphism other I179V polymorphism, may be a novel aetiological factor in the development of asthma and related allergic disorders
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS