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FLASH GENE
Symbol CD84 contributors: mct - updated : 16-02-2016
HGNC name CD84 molecule
HGNC id 1704
Location 1q23.3      Physical location : 160.510.884 - 160.549.306
Synonym name
  • CD84 antigen (leukocyte antigen)
  • cell surface antigen MAX.3
  • signaling lymphocytic activation molecule 5
  • Synonym symbol(s) LY9B, MAX3, SLAMF5, hCD84, mCD84, DKFZp781E2378, Hly9-beta
    DNA
    TYPE functioning gene
    STRUCTURE 38.42 kb     7 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391124 1 similar to ribosomal protein L27a; ribosomal protein L29 homolog (yeast) PIGM 1q22 phosphatidylinositol glycan, class M KCNJ10 1q22 potassium inwardly-rectifying channel, subfamily J, member 10 KCNJ9 1q22 potassium inwardly-rectifying channel, subfamily J, member 9 IGSF8 1q23.1 immunoglobulin superfamily, member 8 ATP1A2 1q22 ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide ATP1A4 1q22 ATPase, Na+/K+ transporting, alpha 4 polypeptide CASQ1 1q22 calsequestrin 1 (fast-twitch, skeletal muscle) PEA15 1q22 phosphoprotein enriched in astrocytes 15 H326 1q22-q23 H326 LOC388707 1 hypothetical gene supported by BC005391; NM_002295 COPA 1q22 coatomer protein complex, subunit alpha PXF 1q22 peroxisomal farnesylated protein NCSTN 1q22 peroxisomal farnesylated protein NHLH1 1q22 nescient helix loop helix 1 VANGL2 1q22 vang-like 2 (van gogh, Drosophila) SLAMF6 1q23.1 SLAM family member 6 CD84 1q22-q23 CD84 antigen (leukocyte antigen) SLAMF1 1q21.3-1q23.2 signaling lymphocytic activation molecule family member 1 CD48 1q23 CD48 antigen (B-cell membrane protein) SLAMF7 1q23.1-q24.1 SLAM family member 7 LY9 1q21.3-q22 lymphocyte antigen 9 CD244 1q23.1 CD244 natural killer cell receptor 2B4 ITLN1 1q21.3 intelectin 1 (galactofuranose binding) LOC284679 1q23.1 similar to spermine synthase; spermidine aminopropyltransferase ITLN2 1q22-q23.5 intelectin 2 F11R 1q21.2-q21.3 F11 receptor USF1 1q22-q23 upstream transcription factor 1 LOC388708 1 similar to KAT protein LOC257106 1q23.1 hypothetical protein LOC257106
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 8245 36.7 328 - 2007 17563375
    6 - 7902 - 214 - 2007 17563375
    6 - 8147 - 272 - 2007 17563375
    8 - 8296 - 345 - 2007 17563375
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Respiratorylung   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticgranulocyte Homo sapiens
    Blood/Hematopoieticmonocyte Homo sapiens
    Blood/Hematopoieticplatelet Homo sapiens
    Lymphoid/ImmuneB cell Homo sapiens
    Lymphoid/Immunedendritic cell Homo sapiens
    Lymphoid/Immunemacrophage Homo sapiens
    Lymphoid/ImmuneT cell Homo sapiens
    not specificmast cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four potential N linked
  • 29 potential O linked glycosylation sites
  • an ectodomain that is highly glycosylated,
  • a cytoplasmic tail containing 2 copies of an ITSM, which can be phosphorylated
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin subtype
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • SLAMF1, CD48, CD84, CD244, LY9, SLAMF6, SLAMF7 play an essential and non-redundant role in the control of humoral immune responses
  • important immunomodulatory receptor with roles in cytotoxicity, humoral immunity, autoimmunity, cell survival, lymphocyte development, and cell adhesion
  • negatively regulates IgE high-affinity receptor signaling in human mast cells
  • natural killer T (NKT) cells and innate CD8(+) T cell development can be regulated in a SAP-dependent and -independent fashion by SLAMF receptors, in which SLAMF1, SLAMF6, and SLAMF8 affect development of NKT cells, and CD84, SLAMF7, and SLAMF8 affect the development of innate CD8(+) T cells
  • is dispensable for thrombus formation and stabilization, indicating that its deficiency may be functionally compensated by other receptors or that it may be important for platelet functions different from platelet-platelet interactions
  • central role for germinal center (GC) B cell-specific CD84 and SLAMF6 expression in maintaining B cell tolerance in GCs and in preventing autoimmunity
  • SLAMF1, CD84, and SLAMF6 are important negative regulators of humoral immune response, consistent with the notion that SLAM family receptors have dual functions in immune responses
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other dual regulation mechanism for platelet CD84 by simultaneous extra- and intracellular cleavage that may modulate platelet-platelet and platelet-immune cell interactions
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in Kawasaki disease (KD)coronary arteries in patients with acute and chronic arterial disease
    tumoral     --over  
    in CLL is an important survival mechanism that appears to be an early event in the pathogenesis of the disease
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    therapeutic strategies based on the blockade of the CD84-dependent survival pathway in Chronic lymphocytic leukemia (CLL)
    ANIMAL & CELL MODELS
  • Cd84(-/-) mice exhibited unaltered hemostatic function and arterial thrombus formation