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FLASH GENE
Symbol CD83 contributors: mct - updated : 03-03-2012
HGNC name CD83 molecule
HGNC id 1703
Location 6p23      Physical location : 14.117.864 - 14.137.146
Synonym name
  • cell differentiation antigen precursor CD83 dendritic cell marker, recognized by monoclonal antibody HB15
  • CD83 antigen (activated B lymphocytes, immunoglobulin superfamily)
  • cell surface protein HB15
  • B-cell activation protein
  • Synonym symbol(s) BL11, HB15
    DNA
    TYPE functioning gene
    STRUCTURE 19.28 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    GCM2 6p23 glial cells missing homolog 2 (Drosophila) LOC221711 6p24.1 hypothetical protein LOC221711 ELOVL2 6p22.3 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 LOC389367 6 LOC389367 LOC389368 6 similar to hypothetical protein D930020E02 NEDD9 6p25-p24 neural precursor cell expressed, developmentally down-regulated 9 C6orf105 6p24.1 chromosome 6 open reading frame 105 LOC389369 6 LOC389369 HIVEP1 6p24.1 human immunodeficiency virus type I enhancer binding protein 1 EDN1 6p24.1 endothelin 1 RPEL1 6p23 RPEL repeat containing 1 TBC1D7 6p23 TBC1 domain family, member 7 GFOD1 6pter-p22.1 glucose-fructose oxidoreductase domain containing 1 C6orf114 6p23 chromosome 6 open reading frame 114 LOC391870 6 similar to ribosomal protein S4, X-linked SIRT5 6p23 sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) RARG-1 RANBP9 6p23 RAN binding protein 9 C6orf79 6p24.3-p23 chromosome 6 open reading frame 79 MGC33993 6p23 hypothetical protein MGC33993 MRPL35P1 6q23 hypothetical protein MGC33993 CD83 6p23 CD83 antigen (activated B lymphocytes, immunoglobulin superfamily) JMJ 6p24-p23 jumonji homolog (mouse) DTNBP1 6p22.3 dystrobrevin binding protein 1 LOC346113 6p22.3 similar to ARP2/3 complex 21 kDa subunit (p21-ARC) (Actin-related protein 2/3 complex subunit 3) LOC391871 6 similar to malate dehydrogenase 1; malate dehydrogenase, soluble; Malate dehydrogenase-like enzyme MYLIP 6p23-p22.3 myosin regulatory light chain interacting protein MRPL42P2 6p22.3 myosin regulatory light chain interacting protein GMPR 6p23 guanosine monophosphate reductase SCA1 6p23 spinocerebellar ataxia 1 (olivopontocerebellar ataxia 1, autosomal dominant, ataxin 1) RNPC6 6p22.3 RNA-binding region (RNP1, RRM) containing 6
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 splicing 2475 22.8 204 - 2005 15905506
  • putative soluble CD83 protein
  • 5 splicing 2478 23 205 - 2005 15905506
    transmembrane CD83 (CD83-TM)
    - splicing 2307 - 146 - 2005 15905506
  • putative soluble CD83 protein
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Lymphoid/Immunelymph node    
     tonsils    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    Lymphoid    
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell Homo sapiens
    Lymphoid/Immunedendritic cell Homo sapiens
    Lymphoid/ImmuneT cell Homo sapiens
    Skin/Tegumentepidermal dendritic cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a single extracellular V type Ig-like domain
  • a transmembrane region
  • a cytoplasmic tail
  • six cystein residues in the extracellular region and one in the membrane spanning domain
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • SIGLEC family
  • immunoglobulin subtype
  • CATEGORY immunity/defense , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • transported from the nucleus to the cytoplasm by an uncommon route, involving the cellular RNA-binding protein ELAVL1 and the nuclear export receptor XPO1
  • basic FUNCTION
  • regulatory compoment for CD4+ T cell development in the thymus
  • expression on T cells and DC (dendritic cells) modulates the immune response by activating DC and by delivering costimulatory signals for the stimulation of naive and memory T cells, respectively
  • CD83 expression can contribute to the immunosuppressive function of CD4(+) T cells
  • fulfil an important role in efficient T-cell activation
  • important regulator of both thymic T cell maturation and peripheral T cell response
  • transduces regulatory signals into the very B cell on which it is expressed
  • also involved in the regulation of B cell maturation, homeostasis and function
  • specific marker for mature dendritic cells
  • important for CD4(+) T-cell development in the thymus
  • CD83-stimulated monocytes suppress T-cell immune responses through production of prostaglandin E2
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with RNF128 (can down-modulate the expression of CD83 on CD4 T cells)
  • cell & other
    REGULATION
    induced by activated T cells that induce CD83 on B cells via CD40 engagement but independent of TCR/MHC binding and thus independent of antigen-specificity of B cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to invasive cervical cancer
  • Variant & Polymorphism other
  • polymorphisms increasing susceptibility to human invasive cervical cancer
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS