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FLASH GENE

Symbol

CD83

contributors: mct - updated : 03-03-2016

HGNC name	CD83 molecule
HGNC id	1703

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6p23      Physical location : 14.117.864 - 14.137.146
Synonym name	cell differentiation antigen precursor CD83 dendritic cell marker, recognized by monoclonal antibody HB15
	CD83 antigen (activated B lymphocytes, immunoglobulin superfamily)
	cell surface protein HB15
	B-cell activation protein
Synonym symbol(s)	BL11, HB15

DNA

TYPE	functioning gene
STRUCTURE	19.28 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001040280 5 splicing 2475 NP_001035370 22.8 204 - 2005 15905506 putative soluble CD83 protein NM_004233 5 splicing 2478 NP_004224 23 205 - 2005 15905506 transmembrane CD83 (CD83-TM) NM_001251901 - splicing 2307 NP_001238830 - 146 - 2005 15905506 putative soluble CD83 protein

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Lymphoid/Immune lymph node           tonsils

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining       Lymphoid         Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune B cell Homo sapiens Lymphoid/Immune dendritic cell Homo sapiens Lymphoid/Immune T cell Homo sapiens Skin/Tegument epidermal dendritic cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a single extracellular V type Ig-like domain
	a transmembrane region
	a cytoplasmic tail
	six cystein residues in the extracellular region and one in the membrane spanning domain

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY	SIGLEC family
	immunoglobulin subtype

CATEGORY

immunity/defense , antigen

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	transported from the nucleus to the cytoplasm by an uncommon route, involving the cellular RNA-binding protein ELAVL1 and the nuclear export receptor XPO1

basic FUNCTION	regulatory compoment for CD4+ T cell development in the thymus
	expression on T cells and DC (dendritic cells) modulates the immune response by activating DC and by delivering costimulatory signals for the stimulation of naive and memory T cells, respectively
	CD83 expression can contribute to the immunosuppressive function of CD4(+) T cells
	fulfil an important role in efficient T-cell activation
	important regulator of both thymic T cell maturation and peripheral T cell response
	transduces regulatory signals into the very B cell on which it is expressed
	also involved in the regulation of B cell maturation, homeostasis and function
	specific marker for mature dendritic cells
	important for CD4(+) T-cell development in the thymus
	CD83-stimulated monocytes suppress T-cell immune responses through production of prostaglandin E2

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with RNF128 (can down-modulate the expression of CD83 on CD4 T cells)
	MARCHF8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selection

cell & other

REGULATION

induced by

activated T cells that induce CD83 on B cells via CD40 engagement but independent of TCR/MHC binding and thus independent of antigen-specificity of B cells

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to invasive cervical cancer

Variant & Polymorphism other	polymorphisms increasing susceptibility to human invasive cervical cancer

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS