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FLASH GENE
Symbol CD80 contributors: mct - updated : 13-02-2015
HGNC name CD80 antigen (CD28 antigen ligand 1, B7-1 antigen)
HGNC id 1700
Location 3q13.33      Physical location : 119.243.141 - 119.278.481
Synonym name
  • B7 activation antigen
  • cell differentiation antigen CD80, identified by monoclonal antibody BB1, B7.1
  • costimulatory molecule variant IgV-CD80
  • Synonym symbol(s) B7A, CD28LG, MIC17, CD28LG1, LAB7, B7, B7-1, B7.1, BB1
    DNA
    TYPE functioning gene
    STRUCTURE 35.00 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    IGSF11 3q21.2 immunoglobulin superfamily, member 11 FLJ32859 3q13.33 hypothetical protein FLJ32859 UPK1B 3q13.3-q21 uroplakin 1B B4GALT4 3q13.3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 CDGAP 3q13.33 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 FLJ10902 3q13.33 hypothetical protein FLJ10902 MDS010 3q13.33 x 010 protein C3orf1 3q13.33 chromosome 3 open reading frame 1 CD80 3q13.3-q21 CD80 antigen (CD28 antigen ligand 1, B7-1 antigen) CSRP2P 3q21.1 cysteine and glycine-rich protein 2 pseudogene ADPRH 3q13.31-q13.33 ADP-ribosylarginine hydrolase PLA1A 3q13.13-q13.2 phospholipase A1 member A LOC391569 3 similar to 60S ribosomal protein L10 (QM protein) (Tumor suppressor QM) (Laminin receptor homolog) POPDC2 3q13.33 popeye domain containing 2 COX17 3p14.3-p14.1 COX17 homolog, cytochrome c oxidase assembly protein (yeast) AAT1 3q12-q13.3 AAT1-alpha NR1I2 3q12-q13.3 nuclear receptor subfamily 1, group I, member 2 GSK3B 3q13.3 glycogen synthase kinase 3 beta LOC389143 3 LOC389143 GPR156 3q13.33 G protein-coupled receptor 156 LOC116064 3q13.33 hypothetical protein LOC116064 FSTL1 3q13.33 follistatin-like 1
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
     tonsils    
    Reproductivefemale systembreastmammary gland  
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Lymphoid/ImmuneB cell
    Lymphoid/Immunedendritic cell
    Lymphoid/Immunelymphocyte
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • Ig variable-like (IgV) domains, Ig constant-like (IgC) domains and intracellular domains
  • a transmembrane domain (1TM)
  • a cytoplasmic domain, component of a costimulatory signal with B7-2 (CD86) and CD28
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Cd80
    Homologene
    FAMILY Ig superfamily, k1 B box family, B7 family
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    text membrane protein type 1
    basic FUNCTION
  • involved in the costimulatory signal essential for t lymphocytes activation
  • T cell proliferation and cytokine production
  • playing a role in stimulating T lymphocyte activation
  • direct signaling through CD86/CD80 is a potent regulator of IgG secretion by previously activated B cells
  • CD80/CD86 engagement results in DC production of the pro-inflammatory cytokine IL6, which is necessary for full T cell activation
  • distinct but complementary roles of CD80 and CD86 IgV and IgC domains in T cell activation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CD28, CD86 ligand
  • SPI1 is a critical factor for the expression of CD80 and CD86
  • interaction of CD86, CD80 with appropriate receptors is essential for an effective T cell response
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    inadequate expression during early oral squamous carcinoma formation may contribute to the escape of tumors from immune elimination
    Susceptibility
  • putative susceptibility gene for rheumatoid arthritis
  • Systemic lupus erythematosus (SLE)
  • Variant & Polymorphism other genetic variants increasing the risk of Systemic lupus erythematosus (SLE)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS