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FLASH GENE
Symbol CD79B contributors: np/ - updated : 22-07-2006
HGNC name CD79b molecule, immunoglobulin-associated beta
HGNC id 1699
Corresponding disease
AGM6 agammaglobulinemia 6
Location 17q23.3      Physical location : 62.006.097 - 62.009.704
Synonym name
  • immunoglobulin-associated B29 in B-cell membrane antigen receptor
  • cell differentiation antigen CD79B
  • CD79B antigen (immunoglobulin-associated beta)
  • B-cell antigen receptor complex-associated protein beta chain
  • immunoglobulin-associated B29 protein
    • Synonym symbol(s) IGB, IGHB, B29
    DNA
    TYPE functioning gene
    STRUCTURE 3.61 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 splicing 1300 26.1 229 - Cragg, Koyama, Hashimoto (1995)
    5 splicing 988 14 125 up-regulated in B-CLL Cragg, Koyama, Hashimoto (1995)
  • containing a 312 bp (104 amino acid) in-frame deletion in the coding region
    • 6 - 1303 - 230 - Kremyanskaya (2005)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     spleen   highly
     tonsils   highly
    Reproductivemale systemprostate  moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    cell lineage
    cell lines
    fluid/secretion lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an immunoglobulin-like V-type domain (ITAM)
    • conjugated GlycoP , PhosphoP
    HOMOLOGY
    interspecies ortholog to murine Igb
    homolog to rattus Igb
    homolog to C.elegans Y119C1B.B
    Homologene
    FAMILY
  • immunoglobulin superfamily
    • CATEGORY antigen , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION
  • encodes the Ig-beta protein of the B-cell antigen component
  • associated to surface IgM-receptor, may be involved in signal transduction
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • B-cell antigen component
  • heterodimer of alpha and beta chains, disulfide-linked
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other phosphorylated on tyrosine as a result of B cell activation
    ASSOCIATED DISORDERS
    corresponding disease(s) AGM6
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS