SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,lysosome
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text
| type II membrane protein |
basic FUNCTION
| playing a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis |
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directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place |
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forms functional complexes with CXCR4 that mediate MIF-specific signaling  |
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is a survival receptor on colon epithelial cells  |
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MIF and CD74 play roles in CCL2-induced macrophage adhesion and migration, and they indicate that MIF and CD74 mediate this effect via both common and independent mechanisms  |
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MIF and its receptor, CD74, are involved in regulating the migration of human mesenchymal stem cells (MSCs  |
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presence of CD74 on statoacoustic ganglion (SAG) neurons supports the existence of a signaling pathway by which MIF influences SAG survival and outgrowth  |
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mediates targeting of the MHCII complex to endosomal compartments, where CD74 undergoes degradation allowing MHCII to acquire peptides  |