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FLASH GENE
Symbol CD72 contributors: - updated : 03-01-2005
HGNC name CD72 antigen
HGNC id 1696
Location 9p13.1      Physical location : 35.609.975 - 35.618.424
Genatlas name cell differentiation antigen CD72,B cell surface protein,CD5 ligand,identified by monoclonal antibodies S-HCL2,Bu-40,Bu-41,J3-109
Synonym name B cell surface protein expressed in preB and mature cells,mouse Lyb-2 antigen homolog
Synonym symbol(s) BCSP, LYB2
DNA
TYPE functioning gene
STRUCTURE 9.00 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a C-type lectin family domain
conjugated GlycoP
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to murine Lyb-2
ortholog to murine Cd72
homolog to C.elegans Y39A1B.1
Homologene
FAMILY
CATEGORY adhesion , antigen , receptor membrane
SUBCELLULAR LOCALIZATION     plasma membrane
text type II membrane protein
basic FUNCTION involved in control of B cell proliferation and differentiation
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component homodimer disulfide-linked
INTERACTION
DNA
RNA
small molecule
protein
  • binding to CD5
  • interacting with FCGR2B to modify susceptibility to systemic lupus erythematosus
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS