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FLASH GENE
Symbol CD72 contributors: - updated : 03-01-2005
HGNC name CD72 antigen
HGNC id 1696
Location 9p13.1      Physical location : 35.609.975 - 35.618.424
Genatlas name cell differentiation antigen CD72,B cell surface protein,CD5 ligand,identified by monoclonal antibodies S-HCL2,Bu-40,Bu-41,J3-109
Synonym name B cell surface protein expressed in preB and mature cells,mouse Lyb-2 antigen homolog
Synonym symbol(s) BCSP, LYB2
DNA
TYPE functioning gene
STRUCTURE 9.00 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC392305 9 similar to GLUL protein LOC158383 9p13.2 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta pseudogene KIAA1045 9p13.2 KIAA1045 DNAJB5 9p11.2 DnaJ (Hsp40) homolog, subfamily B, member 5 LOC392306 9 similar to GCIP-interacting protein p29 LOC138724 VCP 9p13-p12 valosin-containing protein FANCG 9p13 Fanconi anemia, complementation group G PIGO 9p13.2 phosphatidylinositol glycan, class O STOML2 9p13 stomatin (EPB72)-like 2 FLJ11560 9p13.2 hypothetical protein FLJ11560 LOC347241 9p13.2 similar to Zinc finger protein 492 UNC13B 9p12-p11 unc-13 homolog B (C. elegans) PRO0038 9p13.2 PRO0038 protein LOC389717 9 hypothetical gene supported by BC035229; BC047452 RUSC2 9p13.2 RUN and SH3 domain containing 2 LOC138729 9p13.2 hypothetical gene LOC138729 TESK1 9p13 testis-specific kinase 1 CD72 9p13.1 CD72 antigen SIT 9p13-p12 CD72 antigen MGC31967 9p13.2 hypothetical protein MGC31967 FLJ14642 9p13.2 hypothetical protein FLJ14642 CA9 9p13-p12 carbonic anhydrase IX TPM2 9p13.2-p13.1 tropomyosin 2 (beta) TLN1 9p13 talin 1 CREB3 9p13.2 cAMP responsive element binding protein 3 (luman) GBA2 9p13.3-p11.2 glucosidase, beta (bile acid) 2 KIAA0258 9pter-p22.1 KIAA0258 protein NPR2 9p21-p12 natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) SPAG8 9p13-p12 sperm associated antigen 8 HINT2 9p11.2 histidine triad nucleotide binding protein 2 LOC392307 9 similar to RIKEN cDNA 4930412F15 gene NGX6 9p13.1 nasopharyngeal carcinoma related protein LOC389718 9 LOC389718 LOC392308 9 similar to Olfactory receptor 70 LOC392309 9 similar to Olfactory receptor 13J1 LOC392310 9 similar to Phosphoglycerate mutase 1 (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1) OR2S2 9p13.3-p13.1 olfactory receptor, family 2, subfamily S, member 2 LOC389719 9 hypothetical gene supported by M24070; NM_004559 LOC392311 9 similar to seven transmembrane helix receptor OR13C7P 9 olfactory receptor, family 13, subfamily C, member 7 pseudogene LOC392313 9 similar to olfactory receptor RECK 9p13-p12 reversion-inducing-cysteine-rich protein with kazal motifs C9orf19 9p12-p13 chromosome 9 open reading frame 19
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a C-type lectin family domain
conjugated GlycoP
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to murine Lyb-2
ortholog to murine Cd72
homolog to C.elegans Y39A1B.1
Homologene
FAMILY
CATEGORY adhesion , antigen , receptor membrane
SUBCELLULAR LOCALIZATION     plasma membrane
text type II membrane protein
basic FUNCTION involved in control of B cell proliferation and differentiation
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component homodimer disulfide-linked
INTERACTION
DNA
RNA
small molecule
protein
  • binding to CD5
  • interacting with FCGR2B to modify susceptibility to systemic lupus erythematosus
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS