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FLASH GENE
Symbol CD7 contributors: mct - updated : 11-03-2010
HGNC name CD7 molecule
HGNC id 1695
Location 17q25.3      Physical location : 80.272.745 - 80.275.480
Synonym name
  • CD7 antigen (p41)
  • cell differentiation antigen CD7 (p41), identified by monoclonal antibodies 3A1, 4A, CL1.3, G3-7
  • T-cell leukemia antigen
  • T-cell surface antigen Leu-9
  • Synonym symbol(s) GP40, TP41, Tp40 , LEU-9
    DNA
    TYPE functioning gene
    STRUCTURE 2.74 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    regionally located close to SECTM1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1318 - 240 - 1991 1711009
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/HematopoieticNK cell
    Blood/Hematopoieticthymocyte
    Lymphoid/ImmuneB cell
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an immunoglobulin-like domain
  • conjugated GlycoP , LipoP
    HOMOLOGY
    interspecies ortholog to murine Cd7
    homolog to C.elegans C14F5.2
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • CATEGORY immunity/defense , antigen , receptor membrane tyrosine kinase
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION
  • playing an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development
  • may act as an Fc receptor for IgM in lung microvascular endothelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text calcium ion transport
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to SECTM1 (K12)
  • binding to PI3k and to PI4K
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    marker of T cell acute lymphocyte leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • CD7 epxression in CD4+ T cells discriminates between Hodgkin lymphoma (overexpressed) and reactive lymphadenopathy
  • Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    loss of CD7 implies a worse prognosis in adult T-cell leukemia/lymphoma
    ANIMAL & CELL MODELS