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FLASH GENE
Symbol CD69 contributors: mct - updated : 15-02-2016
HGNC name CD69 molecule
HGNC id 1694
Location 12p13.31      Physical location : 9.905.083 - 9.913.497
Synonym name
  • cell differentiation antigen CD69, membrane glycoprotein, identified by monoclonal antibody C1.18
  • CD69 antigen (p60, early T-cell activation antigen)
  • activation inducer molecule (AIM/CD69)
  • early lymphocyte activation antigen
  • C-type lectin domain family 2, member C
  • early T-cell activation antigen p60
  • Synonym symbol(s) CLEC2C, BL-AC/P26, MLR-3, EA1, AIM, Leu-23
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text encoded within the NK C-type lectin cluster
    STRUCTURE 8.41 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure
  • existence of a cis-acting element in intron I that is more accessible to DNase I digestion and that it is developmentally regulated at the chromatin level
  • MAPPING cloned Y linked N status confirmed
    Map see NKG2@
    Physical map
    FLJ25179 12p13.31 hypothetical protein FLJ25179 PHC1 12p13 polyhomeotic-like 1 (Drosophila) M6PR 12p13.2 mannose-6-phosphate receptor (cation dependent) KLRG1 12p13.2-p13.1 killer cell lectin-like receptor subfamily G, member 1 LOC390290 12 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) LOC390291 12 similar to voltage-dependent anion channel isoform 2 MGC40170 12p13.31 hypothetical protein MGC40170 A2M 12p13.2-p13.1 alpha-2-macroglobulin PZP 12p13.2-p13.1 pregnancy-zone protein A2MP 12p13.2-p13.1 alpha-2-macroglobulin pseudogene PTMAP4 12p13.31 prothymosin, alpha pseudogene 4 (gene sequence 112) LOC387832 12 similar to helicase LOC387833 12 LOC387833 LOC387834 12 similar to DKFZp434C0631 protein LOC338812 12p13.31 similar to DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11; DEAD/H box-11 (CHL1-related helicase gene-1); yeast CHL1 homolog LOC347939 12p13.31 similar to Ran-GTP binding protein; RanBP6 LOC390292 12 similar to ovomacroglobulin, ovostatin KLRB1 12p13.1-p12.3 killer cell lectin-like receptor subfamily B, member 1 LOC374443 12p13.31 CLR pseudogene LLT1 12p13 CLR pseudogene LOC387835 12 similar to nucleophosmin 1; nucleolar phosphoprotein B23; numatrin; nucleophosmin/nucleoplasmin family, member 1 DCAL1 12p13.31 dendritic cell-associated lectin-1 CD69 12p13.2-p13.1 CD69 antigen (p60, early T-cell activation antigen) LOC390293 12 similar to ACRC protein; putative nuclear protein KLRF1 12p13.3-p13.2 killer cell lectin-like receptor subfamily F, member 1 CLECSF2 12p13.2-p13.1 C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 2 (activation-induced) LOC387836 12 similar to INPE5792 CLL-1 CLEC2 12p13.31 C-type lectin-like receptor-2 LOC387837 12 similar to macrophage antigen h LOC283420 12p13.31 similar to HEEE9341 CLEC1 12p13.31 C-type lectin-like receptor-1 LOC390294 12 similar to HNRPAB protein CLECSF12 12p13.2-p12.3 C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12 OLR1 12p13.1-p12.3 oxidised low density lipoprotein (lectin-like) receptor 1 FLJ31166 12p13.31 hypothetical protein FLJ31166 GABARAPL1 12p12.3 GABA(A) receptor-associated protein like 1 KLRD1 12p13.2-p13.1 killer cell lectin-like receptor subfamily D, member 1 KLRK1 12p13.2-p13.1 killer cell lectin-like receptor subfamily K, member 1 KLRC4 12p13.2-p13.1 killer cell lectin-like receptor subfamily C, member 4 KLRC3 12p13.2-p13.1 killer cell lectin-like receptor subfamily C, member 3 KLRC2 12p13.2-p13.1 killer cell lectin-like receptor subfamily C, member 2 KLRC1 12p13.2-p13.1 killer cell lectin-like receptor subfamily C, member 1 LOC255308 12p13.31 similar to eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa; eukaryotic translation initiation factor 2G; eukaryotic translation initiation factor 2, subunit 3 (gamma, 52kD) KLRA1 12p13.2-p13.1 killer cell lectin-like receptor subfamily A, member 1 FLJ10292 12p13.31 hypothetical protein FLJ10292
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1676 22.6 199 - 2000 11101293
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticneutrophil
    Blood/HematopoieticNK cell
    Blood/Hematopoieticplatelet
    Lymphoid/ImmuneB cell
    Lymphoid/ImmuneT cell
    cell lineage many other hemopoietic cells
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an extracellular carbohydrate recognition domain homologous with C type lectin family member, group V, like Ly-49, C-type lectin-like domain (CTLD)
  • a glycosylation site with typical or atypical motif-representing the molecular basis for homo or heterodimerization
  • conjugated GlycoP , PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to rattus Cd69
    homolog to murine Cd69
    Homologene
    FAMILY
  • superfamily of type II transmembrane receptors as natural killer cell lectin like NKG2
  • CATEGORY antigen , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • single-pass type II integral membrane glycoprotein
  • expressed at the cell surface as a type II homodimeric membrane protein
  • basic FUNCTION
  • acting as a T cell activation inducer molecule
  • playing a pivotal role in cellular signaling
  • involved in lymphocyte proliferation
  • functioning as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets
  • may participate in such diverse functions as cell aggregation, cellular cytotoxicity, and release of cytokines and inflammatory mediators
  • inhibiting S1P1 chemotactic function and leading to downmodulation of S1P1
  • earliest lymphocyte activation antigen and a universal leukocyte triggering molecule expressed at sites of active immune response
  • plays a crucial role in the pathogenesis of allergen-induced eosinophilic airway inflammation and hyperresponsiveness
  • limits differentiation into proinflammatory helper T cells (Th17 cells)
  • early activation receptor acting as an intrinsic modulator of the T-cell differentiation program that conditions immune inflammatory processes
  • CD69 regulates S1P-induced skin dendritic cells migration by modulating S1P(1) function
  • is critical for the generation and maintenance of professional memory Th lymphocytes, which can efficiently help humoral immunity in the late phase
  • regulates the persistence of memory Th cells on survival niches organized by stromal cells
  • functions as a homing receptor on CD4 T cells and is required for relocation to, and persistence in, the bone marrow, and its function is essential for the generation of memory Th cells
  • is negative regulator of inflammatory responses in intestine as it decreases the expression of chemotactic receptors and ligands and reduces the accumulation of CD4 T cells in colonic lamina propria (cLP) during colitis
  • exerts a complex immunoregulatory role
  • CD69 is involved in immune cell homeostasis, regulating the T cell-mediated immune response through the control of Th17 cell differentiation
  • LGALS1 and CD69 are a novel regulatory receptor-ligand pair that modulates Th17 effector cell differentiation and function
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • disulfide-linked homodimer on the cell surface
  • homodimer composed of heavily glycosylated subunits
  • INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • Ca2+
  • carbohydrates
  • protein
  • CALR
  • integral membrane interaction between CD69 and S1PR1 (CD69 induces an S1PR1 conformation that shares some properties of the ligand-bound state, thereby facilitating S1PR1 internalization and degradation)
  • maintenance of immune tolerance by Foxp3+ regulatory T cells requires CD69 expression
  • expression of CD69, by interfering with S1PR1 function, is a critical determinant of prolonged T cell retention and local memory formation
  • cell & other
    REGULATION
    induced by antigens, mitogens or activators of PKC on the surface of T and B lymphocytes. By interaction of IL-2 with the p75 IL-2R on the surface of NK cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmune 
    target molecule for the therapy of immune-mediated diseases
    allergyasthm 
    could be a possible therapeutic target for asthmatic patients
    ANIMAL & CELL MODELS
  • Cd69 -/- mice (Sancho, 2003)
  • CD69 knockout mice exhibit an enhanced or reduced susceptibility to different experimental models of inflammatory diseases, including those mediated by T helper 17 (Th17) lymphocytes