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FLASH GENE
Symbol CD63 contributors: mct - updated : 16-04-2010
HGNC name CD63 molecule
HGNC id 1692
Location 12q13.2      Physical location : 56.119.230 - 56.122.910
Synonym name
  • CD63 antigen (melanoma 1 antigen)
  • cell differentiation antigen CD63 (melanoma 1 antigen)
  • granulophysin
  • ocular melanoma-associated antigen
  • melanoma-associated antigen ME491
  • tetraspanin-30
  • Synonym symbol(s) MLA1, ME491, LAMP-3, OMA81H, TSPAN30, LIMP-1
    DNA
    TYPE functioning gene
    STRUCTURE 3.68 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    text structure alternate polyadenylation sites
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1031 - 238 - Lin (2008)
    8 - 1025 - 236 - Lin (2008)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text pancreas
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four hydrophobic domains
  • protein region defined by AAs 103-205 interacts not only with amelogenin, but also with other enamel matrix proteins (ameloblastin and enamelin
  • HOMOLOGY
    Homologene
    FAMILY
  • tetraspanin (TM4SF) family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,granule
    text
  • ubiquitous expressed
  • can be translocated to the plasma membrane, where it may be involved in adhesion of granulocytes to endothelial cells
  • located in the membranes of lysosomes and dense granules
  • basic FUNCTION
  • playing a role in the regulation of cell development, activation, growth and motility
  • plays a role in the regulation of KCNJ1 channels through its association with PTPRA, which in turn interacts with and activates Src family PTK, thus reducing KCNJ1 activity
  • may be involved in the integrin-dependent endocytosis and migration capacities of immature dendritic cells but also be able to modulate major histocompatibility complex class II transport to the cell
  • with CD9 ssociate with a type II phosphatidylinositol 4-kinase, PI4K55, in both resting and activated platelets
  • with CD9, CD63 and CD81 are all involved in CD9, CD63 and CD81 are all involved in MGC formation, but play distinct roles formation, but play distinct roles
  • function as organizer of multi-molecular signaling complexes involved in cell morphology, motility and proliferation
  • CD63 is thus a critical mediator of TRAF3 function in- and outside-infected (tumour) cells
  • marked differences in the signaling requirements for expression of ENPP3 and ITGAM versus CD63 expression and histamine release in human basophils
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with integrins
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • CD63 is an essential cofactor to SELP
  • protein
  • interacting with SDCBP
  • interacting with AMELX (AMELX interacts with the transmembrane proteins CD63 and LAMP (lysosome-associated membrane protein) 1, which are involved in endocytosis
  • interacting with SYT7 (palmitoylation-dependent association with the tetraspanin CD63 is the mechanism by which SYT7 is targeted to lysosomes
  • AMBN bound to CD63 and promoted CD63 binding to integrin beta1
  • TIMP1 colocalizes with CD63 on the surface of mesenchymal stem cells (hMSCs)
  • cell & other
  • associated with intracellular major histocompatibility complex class II molecules in immature dendritic cells and B lymphocytes
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    CD63 knockout mice show an increased urinary flow, water intake, reduced urine osmolality, and a higher fecal water content