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Symbol CD63 contributors: mct - updated : 16-04-2010
HGNC name CD63 molecule
HGNC id 1692
Location 12q13.2      Physical location : 56.119.230 - 56.122.910
Synonym name
  • CD63 antigen (melanoma 1 antigen)
  • cell differentiation antigen CD63 (melanoma 1 antigen)
  • granulophysin
  • ocular melanoma-associated antigen
  • melanoma-associated antigen ME491
  • tetraspanin-30
  • Synonym symbol(s) MLA1, ME491, LAMP-3, OMA81H, TSPAN30, LIMP-1
    TYPE functioning gene
    STRUCTURE 3.68 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    text structure alternate polyadenylation sites
    MAPPING cloned Y linked   status provisional
    Physical map
    LOC390321 12 similar to olfactory receptor MOR111-1 LOC254786 12q13.13 similar to olfactory receptor MOR111-4 LOC390322 12 similar to olfactory receptor MOR111-4 LOC390323 12 similar to olfactory receptor MOR112-1 LOC390324 12 similar to olfactory receptor MOR109-1 LOC390325 12 similar to olfactory receptor GA_x6K02T2PULF-11304679-11303744 LOC283368 12q13.13 similar to Polyhomeotic-like protein 1 (Early development regulator protein 1) (HPH1) LOC390326 12 similar to olfactory receptor MOR108-4 LOC341416 12q13.13 similar to olfactory receptor MOR114-1 LOC390327 12 similar to olfactory receptor GA_x6K02T2PULF-11553313-11552381 LOC390328 12 similar to olfactory receptor MOR114-12 LOC341418 12q13.13 similar to Olfactory receptor 6C4 LOC121129 12q13.13 similar to seven transmembrane helix receptor LOC390329 12 similar to seven transmembrane helix receptor LOC121130 12q13.13 similar to seven transmembrane helix receptor PSMB3P 12q12 proteasome (prosome, macropain) subunit, beta type, 3 pseudogene MGC17301 12q13.13 hypothetical protein MGC17301 ITGA7 12q13.3 integrin, alpha 7 GCN5L1 12q13-q14 GCN5 general control of amino-acid synthesis 5-like 1 (yeast) RDH5 12q13-q14 retinol dehydrogenase 5 (11-cis and 9-cis) CD63 12q12-q13 CD63 antigen (melanoma 1 antigen) GDF11 12q12 growth differentiation factor 11 CIP29 12q13.13 cytokine induced protein 29 kDa ORMDL2 12q12 ORM1-like 2 (S. cerevisiae) DNAJ 12q13.13 DnaJ protein MMP19 12q14 matrix metalloproteinase 19 PYM 12q13.13 PYM protein DGKA 12q13.3 diacylglycerol kinase, alpha 80kDa SILV 12q13-q14 silver homolog (mouse) CDK2 12q13.3 cyclin-dependent kinase 2 SUOX RAB5B 12q13 RAB5B, member RAS oncogene family ZNFN1A4 12q13 zinc finger protein, subfamily 1A, 4 (Eos) RPS26 12q14 ribosomal protein S26 ERBB3 12q13.3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) PA2G4 12q13 proliferation-associated 2G4, 38kDa RPL41 12q14 ribosomal protein L41 FLJ14451 12q13.13 hypothetical protein FLJ14451
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1031 - 238 - Lin (2008)
    8 - 1025 - 236 - Lin (2008)
    Type ubiquitous
       expressed in (based on citations)
    cell lineage
    cell lines
    at STAGE
    physiological period fetal
    Text pancreas
  • four hydrophobic domains
  • protein region defined by AAs 103-205 interacts not only with amelogenin, but also with other enamel matrix proteins (ameloblastin and enamelin
  • tetraspanin (TM4SF) family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
  • ubiquitous expressed
  • can be translocated to the plasma membrane, where it may be involved in adhesion of granulocytes to endothelial cells
  • located in the membranes of lysosomes and dense granules
  • basic FUNCTION
  • playing a role in the regulation of cell development, activation, growth and motility
  • plays a role in the regulation of KCNJ1 channels through its association with PTPRA, which in turn interacts with and activates Src family PTK, thus reducing KCNJ1 activity
  • may be involved in the integrin-dependent endocytosis and migration capacities of immature dendritic cells but also be able to modulate major histocompatibility complex class II transport to the cell
  • with CD9 ssociate with a type II phosphatidylinositol 4-kinase, PI4K55, in both resting and activated platelets
  • with CD9, CD63 and CD81 are all involved in CD9, CD63 and CD81 are all involved in MGC formation, but play distinct roles formation, but play distinct roles
  • function as organizer of multi-molecular signaling complexes involved in cell morphology, motility and proliferation
  • CD63 is thus a critical mediator of TRAF3 function in- and outside-infected (tumour) cells
  • marked differences in the signaling requirements for expression of ENPP3 and ITGAM versus CD63 expression and histamine release in human basophils
    a component
  • complexing with integrins
    small molecule metal binding,
  • CD63 is an essential cofactor to SELP
  • protein
  • interacting with SDCBP
  • interacting with AMELX (AMELX interacts with the transmembrane proteins CD63 and LAMP (lysosome-associated membrane protein) 1, which are involved in endocytosis
  • interacting with SYT7 (palmitoylation-dependent association with the tetraspanin CD63 is the mechanism by which SYT7 is targeted to lysosomes
  • AMBN bound to CD63 and promoted CD63 binding to integrin beta1
  • TIMP1 colocalizes with CD63 on the surface of mesenchymal stem cells (hMSCs)
  • cell & other
  • associated with intracellular major histocompatibility complex class II molecules in immature dendritic cells and B lymphocytes
    corresponding disease(s)
    Variant & Polymorphism
    Candidate gene
    Therapy target
    CD63 knockout mice show an increased urinary flow, water intake, reduced urine osmolality, and a higher fecal water content