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FLASH GENE
Symbol CD6 contributors: mct - updated : 24-08-2016
HGNC name CD6 antigen
HGNC id 1691
Location 11q12.12      Physical location : 60.739.114 - 60.787.846
Genatlas name cell differentiation antigen CD6,identified by monoclonal antibodies M-T502,M-T606-M-T603,SPVL14
Synonym symbol(s) TP120
DNA
TYPE functioning gene
STRUCTURE 48.74 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map cen - MS4A2 - D11S461 - CD6 - D11S765 - CD5 - PGA@ - DDB1 - D11S678 - D11S2319E - D11S2224E - SYT7 - D11S734 - FEN1 - D11S699 - D11S471 - FTH1 - SCGB1A1 - AHNAK - qter
Authors Bowen (97),Cooper (98)
Physical map
MS4A2 11q12.2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) MS4A6A 11q12.1 membrane-spanning 4-domains, subfamily A, member 6A LOC390204 11 similar to membrane-spanning 4-domains, subfamily A, member 4 isoform b; membrane-spanning 4-domains, subfamily A, member 4A; four-span transmembrane protein; Fc epsilon receptor beta subunit homolog MS4A4A 11q12 membrane-spanning 4-domains, subfamily A, member 4 MS4A6E 11q12.1 membrane-spanning 4-domains, subfamily A, member 6E MS4A7 11q12.1 membrane-spanning 4-domains, subfamily A, member 7 NYD-SP21 11q12.2 testes development-related NYD-SP21 MS4A5 11q12 membrane-spanning 4-domains, subfamily A, member 5 MS4A1 11q12.2-q13.1 membrane-spanning 4-domains, subfamily A, member 1 MS4A12 11q12.1 membrane-spanning 4-domains, subfamily A, member 12 MGC39681 11q12.2 hypothetical protein MGC39681 MS4A8B 11q12.1 membrane-spanning 4-domains, subfamily A, member 8B MGC35295 11q12.2 hypothetical protein MGC35295 LOC341116 11q12.2 similar to Membrane-spanning 4-domains subfamily A member 10 MGC2574 11q12.2 hypothetical protein MGC2574 GPR44 11q12-q13.3 G protein-coupled receptor 44 LOC255714 11q12.2 similar to ZP1 precursor NMP200 11q12.2 nuclear matrix protein NMP200 related to splicing factor PRP19 MGC5508 11q12.2 hypothetical protein MGC5508 GBP 11q12.2 likely ortholog of rat GRP78-binding protein SLC15A3 11q13.1 solute carrier family 15, member 3 CD6 11q13 CD6 antigen CD5 11q12.2 CD5 antigen (p56-62) FLJ20847 11q12.3 hypothetical protein FLJ20847 PGA5 11q13 pepsinogen 5, group I (pepsinogen A) FLJ32009 11q12.3 hypothetical protein FLJ32009 DDB1 11q12-q13.1 damage-specific DNA binding protein 1, 127kDa DKFZP586B1621 11q12.3 DKFZP586B1621 protein MGC20446 11q12.3 hypothetical protein MGC20446 HSPC196 11q12.3 hypothetical protein HSPC196 MGC:13379 11q13.1 HSPC244 FLJ12529 11q12.3 pre-mRNA cleavage factor I, 59 kDa subunit FLJ20487 11q12.3 hypothetical protein FLJ20487 FLJ32771 11q12.3 IIIG9 protein SYT7 11q12-q13.1 synaptotagmin VII LOC390205 11 similar to leucine-rich repeat-containing 10; leucine-rich repeat protein; leucine-rich containing 10 RPLP0P2 11cen-q12 ribosomal protein, large, P0 pseudogene 2 C11orf11 11q13.1 chromosome 11 open reading frame 11 C11orf9 11q12-q13.1 chromosome 11 open reading frame 9 C11orf10 11q12-q13.1 chromosome 11 open reading frame 10 FEN1 11q13.1 flap structure-specific endonuclease 1 FADS1 11q12.2-q13.1 fatty acid desaturase 1 FADS2 11q12-q13.1 fatty acid desaturase 2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 3074 - 592 - 2013 23711376
11 - 3101 - 601 - 2013 23711376
13 - 3309 - 668 - 2013 23711376
- splicing - - - - 2014 24890719
  • alternatively spliced isoform that lacks the ligand-binding domain and thus no longer localizes at the immunological synapse
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Nervousnervespinal nervesciatic  
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebonesubchondral  
    Lymphoid    
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte Homo sapiens
    Blood/Hematopoieticthymocyte
    Lymphoid/ImmuneB cell Homo sapiens
    Lymphoid/ImmuneT cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • transmembrane protein (TM1) with three extracellular scavenger receptor cysteine-rich domains (SRCR,group B)
  • cytoplasmic tail lacks intrinsic catalytic activity but presents several consensus motifs for phosphorylation
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Cd6
    Homologene
    FAMILY
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type1 membrane protein
    basic FUNCTION
  • involved in cell adhesion
  • is likely a signaling attenuator whose expression alone, i.e. in the absence of ligand engagement, is sufficient to restrain signaling in T cells
  • modulator of cellular responses and implicated in several autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and psoriasis
  • role of CD6 in autoimmunity
  • lymphocyte surface receptor putatively involved in T cell development and activation
  • modulates the threshold for thymocyte selection and the generation and/or function of several peripheral T cell subpopulations, including T reg cells
  • CELLULAR PROCESS cell life
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • direct interaction between LCP2 and CD6 was shown by binding both to a phosphorylated peptide
  • contribute to DC-T-cell adhesion, stabilize DC-T-cell contacts and form a mechanical link between CD6 and the actin cortex to strengthen cell adhesion at the immunological synapse
  • upon T cell activation, SRSF1 becomes limiting, and its function in CD6 exon 5 splicing is countered by an increase in CD6 transcription, dependent on chromatin acetylation
  • interaction of LGALS1 and LGALS3 with CD6 and CD166/ALCAM might modulate some relevant aspects of T cell physiology
  • interaction between CD6 and ALCAM regulating T-cell activation
  • facilitates adhesion between T cells and antigen-presenting cells through its interaction with ALCAM, and physically associates with the T cell receptor (TCR) at the center of the immunological synapse
  • novel interactions between the SH2D2A SH2 domain and CD6 phosphotyrosine (pTyr)629 and linker of activated T cells (LAT) pTyr171 , pTyr191 and pTyr226
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to multiple sclerosis
    Variant & Polymorphism SNP rs17824933 increasing susceptibility to multiple sclerosis, and is associated with decreased expression of full-length CD6 in CD4(+) and CD8(+) T cells
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS