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FLASH GENE
Symbol CD6 contributors: mct - updated : 24-08-2016
HGNC name CD6 antigen
HGNC id 1691
Location 11q12.12      Physical location : 60.739.114 - 60.787.846
Genatlas name cell differentiation antigen CD6,identified by monoclonal antibodies M-T502,M-T606-M-T603,SPVL14
Synonym symbol(s) TP120
DNA
TYPE functioning gene
STRUCTURE 48.74 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map cen - MS4A2 - D11S461 - CD6 - D11S765 - CD5 - PGA@ - DDB1 - D11S678 - D11S2319E - D11S2224E - SYT7 - D11S734 - FEN1 - D11S699 - D11S471 - FTH1 - SCGB1A1 - AHNAK - qter
Authors Bowen (97),Cooper (98)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 3074 - 592 - 2013 23711376
11 - 3101 - 601 - 2013 23711376
13 - 3309 - 668 - 2013 23711376
- splicing - - - - 2014 24890719
  • alternatively spliced isoform that lacks the ligand-binding domain and thus no longer localizes at the immunological synapse
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Nervousnervespinal nervesciatic  
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebonesubchondral  
    Lymphoid    
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte Homo sapiens
    Blood/Hematopoieticthymocyte
    Lymphoid/ImmuneB cell Homo sapiens
    Lymphoid/ImmuneT cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • transmembrane protein (TM1) with three extracellular scavenger receptor cysteine-rich domains (SRCR,group B)
  • cytoplasmic tail lacks intrinsic catalytic activity but presents several consensus motifs for phosphorylation
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Cd6
    Homologene
    FAMILY
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type1 membrane protein
    basic FUNCTION
  • involved in cell adhesion
  • is likely a signaling attenuator whose expression alone, i.e. in the absence of ligand engagement, is sufficient to restrain signaling in T cells
  • modulator of cellular responses and implicated in several autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and psoriasis
  • role of CD6 in autoimmunity
  • lymphocyte surface receptor putatively involved in T cell development and activation
  • modulates the threshold for thymocyte selection and the generation and/or function of several peripheral T cell subpopulations, including T reg cells
  • CELLULAR PROCESS cell life
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • direct interaction between LCP2 and CD6 was shown by binding both to a phosphorylated peptide
  • contribute to DC-T-cell adhesion, stabilize DC-T-cell contacts and form a mechanical link between CD6 and the actin cortex to strengthen cell adhesion at the immunological synapse
  • upon T cell activation, SRSF1 becomes limiting, and its function in CD6 exon 5 splicing is countered by an increase in CD6 transcription, dependent on chromatin acetylation
  • interaction of LGALS1 and LGALS3 with CD6 and CD166/ALCAM might modulate some relevant aspects of T cell physiology
  • interaction between CD6 and ALCAM regulating T-cell activation
  • facilitates adhesion between T cells and antigen-presenting cells through its interaction with ALCAM, and physically associates with the T cell receptor (TCR) at the center of the immunological synapse
  • novel interactions between the SH2D2A SH2 domain and CD6 phosphotyrosine (pTyr)629 and linker of activated T cells (LAT) pTyr171 , pTyr191 and pTyr226
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to multiple sclerosis
    Variant & Polymorphism SNP rs17824933 increasing susceptibility to multiple sclerosis, and is associated with decreased expression of full-length CD6 in CD4(+) and CD8(+) T cells
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS