basic FUNCTION
| potential regulator of monocyte activation |
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function and/or survival |
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may play a role in the regulation of the immune system |
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playing a role as an inhibitor of apoptosis |
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being a critical factor protecting macrophages from the apoptotic effects of oxidized lipids |
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facilitating macrophage survival within atherosclerotic lesions (Arai 2005) |
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inhibits TNF-alpha secretion by monocytes stimulated with LPS or LTA, indicating that its an active constituent of the innate immune response of the host (Sarrias 2005) |
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CD5L function in adipocytes may be physiologically relevant to obesity progression |
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induces lipolysis in a manner distinct from that of hormone-dependent lipolysis, without activation or augmentation of lipases |
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N-glycosylation plays important roles in the secretion and lipolytic function of CD5L |
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reduces mRNA levels of lipid-droplet coating proteins leading to lipolysis |
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is endocytosed into adipocytes, associates with FAS and suppresses its enzymatic activity, which reduces endogenous generation of fatty acids, resulting in decreased PPARG activity leading to downregulation of CIDEC and Perilipin mRNA levels |
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contributes to key macrophage responses to M. tuberculosis |
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plays likely a general homeostatic role by supporting innate humoral defense during pathogen aggression |
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secreted glycoprotein that participates in host response to bacterial infection |
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binds to IGFBP2, IGFBP3 and IGFBP4, and this interaction may contribute to the mechanism of CD5L-mediated anti-apoptosis function |
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regulates lipid biosynthesis and restrains Th17 cell pathogenicity |