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FLASH GENE
Symbol CD5L contributors: mct - updated : 01-06-2017
HGNC name CD5 molecule-like
HGNC id 1690
Location 1q23.1      Physical location : 157.800.705 - 157.811.634
Synonym name
  • lymphocyte antigen CD5-like
  • scavenger receptor cysteine-rich family, member SP-alpha
  • IgM-associated peptide
  • apoptosis inhibitor of macrophages
  • CD5 antigen-like (scavenger receptor cysteine rich family)
  • apoptosis inhibitor 6
  • Synonym symbol(s) SPA, API6, PRO229, AIM, Spalpha, CT-2, SP-ALPHA
    DNA
    TYPE functioning gene
    STRUCTURE 14.77 kb     6 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    text 3 mRNAs of 2.4, 2.1, and 1.8 kb on Northern blots (Gebe (97))
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2248 - 347 - 2015 26135353
    - - 1736 - 347 - 2015 26135353
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus    
    Lymphoid/Immunespleen   predominantly
    Reproductivefemale systemplacenta  lowly
    Visualeyeretina    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Epithelialbarrier liningretinal pigment epithelium (RPE)   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage Homo sapiens
    Nervousglia Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES globular
    STRUCTURE
    motifs/domains
  • 19AA signal sequence
  • three scavenger cysteine rich (SRCR) domains
  • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Cd5l (70.1pc)
    Homologene
    FAMILY
  • scavenger receptor cysteine-rich family
  • CATEGORY immunity/defense , regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • secreted
  • basic FUNCTION
  • potential regulator of monocyte activation
  • function and/or survival
  • may play a role in the regulation of the immune system
  • playing a role as an inhibitor of apoptosis
  • being a critical factor protecting macrophages from the apoptotic effects of oxidized lipids
  • facilitating macrophage survival within atherosclerotic lesions (Arai 2005)
  • inhibits TNF-alpha secretion by monocytes stimulated with LPS or LTA, indicating that its an active constituent of the innate immune response of the host (Sarrias 2005)
  • CD5L function in adipocytes may be physiologically relevant to obesity progression
  • induces lipolysis in a manner distinct from that of hormone-dependent lipolysis, without activation or augmentation of lipases
  • N-glycosylation plays important roles in the secretion and lipolytic function of CD5L
  • reduces mRNA levels of lipid-droplet coating proteins leading to lipolysis
  • is endocytosed into adipocytes, associates with FAS and suppresses its enzymatic activity, which reduces endogenous generation of fatty acids, resulting in decreased PPARG activity leading to downregulation of CIDEC and Perilipin mRNA levels
  • contributes to key macrophage responses to M. tuberculosis
  • plays likely a general homeostatic role by supporting innate humoral defense during pathogen aggression
  • secreted glycoprotein that participates in host response to bacterial infection
  • binds to IGFBP2, IGFBP3 and IGFBP4, and this interaction may contribute to the mechanism of CD5L-mediated anti-apoptosis function
  • regulates lipid biosynthesis and restrains Th17 cell pathogenicity
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS immunity/defense
    text cellular defense response
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associated with IgM
  • within adipocytes, CD5L associates with cytosolic fatty acid synthase (FASN), thereby decreasing FASN activity
  • CD36 is involved in autophagy and there is a significant contribution of the CD5L-CD36 axis to the induction of macrophage autophagy
  • binds to insulin&
  • 8209;like growth factor binding protein&
    8209;4 (IGFBP4)
    cell & other
  • binding to the surface of several Gram-positive and Gram-negative bacterial strains (Sarrias 2005)
  • REGULATION
    induced by oxidized lipids
    Other expression of CD5L is transcriptionally controlled by LXRs, members of the nuclear receptor family that play major roles in lipid homeostasis
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    significantly upregulated in the plasma from Atopic Dermatitis patients (Kim 2008)
    constitutional     --over  
    CD5L levels were markedly higher in patients with advanced liver damage, regardless of disease type, and correlated significantly with multiple parameters representing liver function
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • up-regulated CD5L in AD patients cause eosinophilia by inhibiting apoptosis or promoting the proliferation of eosinophils either in combination with or without IL5 (Kim 2008)
  • Marker
    Therapy target
  • can be used as a candidate marker for Atopic Dermatitis (Kim 2008)
  • SystemTypeDisorderPubmed
    obesity  
    selective regulation of lipolysis that is AIM-induced via AIM modulation might be a promising target for next-generation therapy against obesity
    diabetemetabolic syndrom 
    CD5L suppression might be therapeutically applicable for the prevention of obesity-related metabolic disorders
    ANIMAL & CELL MODELS
  • After Cd5l overexpression, lung adenocarcinoma was observed in bitransgenic mice, suggesting that dysregulation of myeloid cells populations by extracellular Cd5l signaling leads to abnormal myelopoiesis and lung cancer (Qu 2009)