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FLASH GENE
Symbol CD53 contributors: - updated : 14-12-2005
HGNC name CD53 molecule
HGNC id 1686
Location 1p13.3      Physical location : 111.413.820 - 111.442.557
Synonym name
  • cell differentiation antigen 53, 32-40kDa, single chain glycoprotein, identified by monoclonal antibodies H129, H136, MEM-53, HD77
  • CD53 antigen
  • Synonym symbol(s) D1S2237E, MOX44, TSPAN25
    DNA
    TYPE functioning gene
    STRUCTURE 26.00 kb     8 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    CSF1 1p21-p13.3 colony stimulating factor 1 (macrophage) AHCYL1 1p12 S-adenosylhomocysteine hydrolase-like 1 PRO0233 1p13.2 PRO0233 protein ALX3 1p23-p21 aristaless-like homeobox 3 LOC164153 1p13.2 similar to RIKEN cDNA 4930522D07 LOC388661 1 LOC388661 LOC388662 1 similar to Orphan sodium- and chloride-dependent neurotransmitter transporter NTT4 KCNC4 1p21 potassium voltage-gated channel, Shaw-related subfamily, member 4 LOC388663 1 LOC388663 RBM15 1p13 RNA binding motif protein 15 SLC16A4 1p13.1 solute carrier family 16 (monocarboxylic acid transporters), member 4 HBXIP 1p13.1 hepatitis B virus x interacting protein PROK1 1p21 prokineticin 1 LOC388664 1 similar to prochymosin KCNA10 1p13.1 potassium voltage-gated channel, shaker-related subfamily, member 10 KCNA2 1p13 potassium voltage-gated channel, shaker-related subfamily, member 2 KCNA3 1p13.3 potassium voltage-gated channel, shaker-related subfamily, member 3 LOC137829 1p13.2 similar to Nuclear receptor binding factor-2 CD53 1p13 CD53 antigen RIF1 1p13.2 receptor-interacting factor 1 MGC54289 1p13.2 hypothetical protein MGC54289 CEPT1 1p12 choline/ethanolaminephosphotransferase FLJ22457 1p13.2 hypothetical protein FLJ22457 CHI3L2 1p13.3 chitinase 3-like 2 LOC149620 1p13.2 similar to CHIA protein CHIA 1p21.3-p13.1 similar to CHIA protein LOC128344 1p13.2 hypothetical protein LOC128344 LOC388665 1 similar to DKFZP564K247 protein LOC391066 1 similar to pepsinogen B OVGP1 1p13 oviductal glycoprotein 1, 120kDa (mucin 9, oviductin) MEP50 1p13.2 MEP50 protein ATP5F1 1p12 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b, isoform 1 MGC24133 1p13.2 hypothetical protein MGC24133 AD026 1p13.1 AD026 protein ADORA3 1p13.3 adenosine A3 receptor RAP1A 1p13.3 RAP1A, member of RAS oncogene family LOC55924 1pter-q31.3 hypothetical protein LOC55924 DDX20 1p21.1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 KCND3 1p13.2 potassium voltage-gated channel, Shal-related subfamily, member 3
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   moderately
     spleen   highly
     thymus   predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Blood/Hematopoieticneutrophil
    Lymphoid/ImmuneB cell
    Lymphoid/Immunemacrophage
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophilic Hydrophobic
    STRUCTURE
    motifs/domains
  • four transmembrane hydrophobic domains
  • a major extracellular hydrophilic loop containing 2 potential N-glycosylation sites
  • conjugated GlycoP
    mono polymer complex
    HOMOLOGY
    interspecies ortholog to rattus Cd53
    ortholog to murine Cd53
    homolog to drosophila Tsp39D
    Homologene
    FAMILY transmembrane 4 superfamily member, tetraspanin (TM4SF)
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • integral to plasma membrane
  • basic FUNCTION
  • may be involved in growth regulation in hematopoietic cells
  • contributing to the transduction of CD2-generated signals in T cells and natural killer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • involved in a complex with integrins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS