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FLASH GENE
Symbol CD53 contributors: - updated : 14-12-2005
HGNC name CD53 molecule
HGNC id 1686
Location 1p13.3      Physical location : 111.413.820 - 111.442.557
Synonym name
  • cell differentiation antigen 53, 32-40kDa, single chain glycoprotein, identified by monoclonal antibodies H129, H136, MEM-53, HD77
  • CD53 antigen
  • Synonym symbol(s) D1S2237E, MOX44, TSPAN25
    DNA
    TYPE functioning gene
    STRUCTURE 26.00 kb     8 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   moderately
     spleen   highly
     thymus   predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Blood/Hematopoieticneutrophil
    Lymphoid/ImmuneB cell
    Lymphoid/Immunemacrophage
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophilic Hydrophobic
    STRUCTURE
    motifs/domains
  • four transmembrane hydrophobic domains
  • a major extracellular hydrophilic loop containing 2 potential N-glycosylation sites
  • conjugated GlycoP
    mono polymer complex
    HOMOLOGY
    interspecies ortholog to rattus Cd53
    ortholog to murine Cd53
    homolog to drosophila Tsp39D
    Homologene
    FAMILY transmembrane 4 superfamily member, tetraspanin (TM4SF)
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • integral to plasma membrane
  • basic FUNCTION
  • may be involved in growth regulation in hematopoietic cells
  • contributing to the transduction of CD2-generated signals in T cells and natural killer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • involved in a complex with integrins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS