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FLASH GENE
Symbol CD52 contributors: SGE/npt - updated : 16-07-2010
HGNC name CD52 molecule
HGNC id 1804
Location 1p36.11      Physical location : 26.644.410 - 26.647.013
Synonym name
  • CAMPATH1 antigen
  • CDW52 antigen (CAMPATH-1 antigen)
  • leukocyte differentiation antigen
  • CD52 antigen (CAMPATH-1 antigen)
  • cambridge pathology 1 antigen
  • epididymal secretory protein E5
  • Synonym symbol(s) HE5, CDW52
    DNA
    TYPE functioning gene
    STRUCTURE 2.60 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map pter - D1S2843 - D1S2732 - CDC42 - D1S2674 - CD52 - EYA3 - D1S2749 - D1S2639 - BAI2 - D1S247 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 523 - 61 - Xia (1991)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    reproductiveepididymis   highly
    Reproductivemale systemmale genital tractvas deferens  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
     mast cell
    Blood/Hematopoieticleukocyte
    Blood/Hematopoieticmonocyte
    Lymphoid/Immunelymphocyte
    Reproductiveepididymal cell
    cell lineage
    cell lines
    fluid/secretion male genital tract, inserted in the sperm membrane
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • antigen comprising a small glycosyl-phosphatidylinositol (GPI) anchored protein to which a large carbohydrate moiety is linked and a 24-residue signal peptide
  • conjugated GlycoP , LipoP
    HOMOLOGY
    interspecies homolog to murine B7-antigen and HE5 epididymal gene
    Homologene
    FAMILY
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • attached to the membrane by a GPI anchor
  • synthetized in cumulus cells and secreted into the cumulus matrix during ovulation (Hasegawa 2008)
  • basic FUNCTION
  • has some functional roles around fertilization (Flori 2008)
  • serving as receptor for semenogelin I during clot formation and liquefaction of semen
  • may play a role in carrying and oritentating carbohydrates
  • costimulatory molecule for induction of CD4+ regulatory T cells (Watanabe 2006)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • a complex with semenogelin (Flori 2008)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
  • CD52 polymorphism may affect the efficiency of GPI-anchor formation and thus may indirectly alter the response to anti-CD52 agents in renal transplants recipient (Oko 2009)
  • Candidate gene
    Marker
    Therapy target
  • potential therapeutic target in Waldenstrom's macroglobulinemia and mast cell disorders (Santos 2006)
  • ANIMAL & CELL MODELS