basic FUNCTION
| playing a role in T-cell regulation and in T cell-mediated inflammatory responses |
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measles virus receptor |
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complement regulatory receptor for C3b and involved in regulation of complement activation |
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preventing complement activation in the syncytiotrophoblast layer of placenta |
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importance of CD46 as a cell target that might confer pathogens some biological advantages over the host  |
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CD46-induced Tregs might play a role in intestinal immune homeostasis where they could dampen unwanted effector T cell responses through local IL10/granzyme B production  |
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CD46-induced Treg enhance B-cell responses  |
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surface receptor able to bind several different pathogens, and sufficient to induce autophagy  |
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upon microorganism recognition, cell surface pathogen receptor that can directly trigger autophagy, a critical step to control infection  |
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having complement and T cell regulatory functions in human cells  |
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functions primarily as a complement control protein by preventing host cell lysis by autologous complement  |
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ligation of CD46 influences T cell signaling, proliferation and fate  |
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C3AR1 and CD46 activation via intrinsic generation of their respective ligands is an integral part of human Th1 (but not Th2) immunity  |
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