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FLASH GENE
Symbol CD4 contributors: mct/npt - updated : 25-04-2017
HGNC name CD4 molecule
HGNC id 1678
Location 12p13.31      Physical location : 6.898.637 - 6.929.976
Synonym name
  • antigen identified by monoclonal antibodies T4,Leu-3a,91D6
  • CD4 antigen (p55)
  • CD4 receptor
  • T-cell surface antigen T4/Leu-3
  • cluster determinant 4
  • Synonym symbol(s) CD4mut
    DNA
    TYPE functioning gene
    STRUCTURE 31.33 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure
  • a tissue-specific promoter made of an initiator-like sequence
  • a locus control region like,see LCR-CD4
  • an ETS and an ATF consensus site
  • MAPPING cloned Y linked Y status confirmed
    Physical map
    LOC390284 12 similar to signal recognition particle 14kDa (homologous Alu RNA binding protein); signal recognition particle 14kD (homologous Alu RNA-binding protein); signal recognition particle 14kD (homologous Alu RNA binding protein) TNFRSF7 12p13 tumor necrosis factor receptor superfamily, member 7 TAPBP-R 12p13.31 TAP binding protein related VAMP1 12p13.31-p13.2 vesicle-associated membrane protein 1 (synaptobrevin 1) PKP2P1 12p13 vesicle-associated membrane protein 1 (synaptobrevin 1) MRPL51 12p13.3-p13.1 mitochondrial ribosomal protein L51 CNAP1 12p13.3 chromosome condensation-related SMC-associated protein 1 GAPD 12p13.31 glyceraldehyde-3-phosphate dehydrogenase HOM-TES-103 12p13.3 HOM-TES-103 tumor antigen-like NOL1 12p13.31 nucleolar protein 1, 120kDa CHD4 12p13 chromodomain helicase DNA binding protein 4 GPR92 12p13.32 G protein-coupled receptor 92 ACRBP 12p13.32 acrosin binding protein ING4 12p13.32 inhibitor of growth family, member 4 ZNF384 12p12 zinc finger protein 384 DKFZp547D2210 12p13.31 hypothetical protein DKFZp547D2210 COPS7A 12p13.32 COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) MLF2 12p13 myeloid leukemia factor 2 PTMS 12p13.32 parathymosin LAG3 12p13.32 lymphocyte-activation gene 3 CD4 12p13.31 CD4 antigen (p55) GRCA 12p13 likely ortholog of mouse gene rich cluster, A gene LEPREL2 12q13 leprecan-like 2 protein USP5 12p13 ubiquitin specific protease 5 (isopeptidase T) GNB3 12p13.31 guanine nucleotide binding protein (G protein), beta polypeptide 3 CDCA3 12p13 cell division cycle associated 3 TPI1 12p13.31 triosephosphate isomerase 1 GRCC9 12p13.31 likely ortholog of mouse gene rich cluster, C9 gene B7 12p13 B7 gene ENO2 12p13.31 enolase 2, (gamma, neuronal) DRPLA 12p13.31 dentatorubral-pallidoluysian atrophy (atrophin-1) GRCC10 12p13.31 likely ortholog of mouse gene rich cluster, C10 gene PTPN6 12p13.31 protein tyrosine phosphatase, non-receptor type 6 REA 12p13.31 protein tyrosine phosphatase, non-receptor type 6 C2F 12p13 C2f protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 3103 58 458 - Fragoso (2003), Wittlich (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four modular ectodomains (D1-D4) (Ashish 2008)
  • an extracellular domain of 370 AAs
  • a short transmembrane region
  • a cytoplasmic domain of 40 AAs at the C-terminal end (Wittlich 2007)
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • Ig superfamily
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane glycoprotein (Wittlich 2007)
    basic FUNCTION
  • HIV and MHC class II receptor
  • CD4-induced aggregation of lipid rafts may play an additional role in CD4 signaling besides its adhesion to MHC molecules (Fragoso 2003)
  • plays essential roles in the immune defence and in T lymphocytes, with PTK2 localise to the same signalling complexes after stimulation by either the human immunodeficiency virus (HIV) gp120 glycoprotein or an antigen (Garron 2008)
  • glycoprotein involved in T-cell development and antigen recognition (Achour 2009)
  • role of CD4, which contributes to regulating CCR5 export to the plasma membrane (Achour 2009)
  • CELLULAR PROCESS cell life, cell death/apoptosis
    cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    cell-cell interaction
    a component
  • constituent of transmembrane glycoprotein
  • PTK2-CD4 complex represents an alternative route for eliciting T-cell-specific signals and it links gp120 engagement to distinctive T-cell signalling during HIV infection (Garron 2008)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • activated LCK, through T cell receptor
  • leading to BAX increase and mitochondrial damage in the absence of VAV exchange factor
  • interacting with PLSCR1 and SLPI (the same region of the cytoplasmic domain of PLSCR1 is involved in the binding to CD4 and SLPI) (Py 2009)
  • CCR5-CD4 association, which occurs in the endoplasmic reticulum, enhanced CCR5 export to the plasma membrane in a concentration-dependent manner, whereas inhibition of endogenous CD4 with small interfering RNAs decreased cell-surface expression of endogenous CCR5 (Achour 2009)
  • binding PTK2 (Garron 2008)
  • modulates reversible and epigenetic silencing of the CD4 gene
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in striatum and caudate from HD patients Mazarei 2010)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS