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FLASH GENE
Symbol CD3G contributors: mct - updated : 20-03-2013
HGNC name CD3g molecule, gamma (CD3-TCR complex)
HGNC id 1675
Corresponding disease
CD3G immunodeficiency, severe, combined, 3G
Location 11q23.3      Physical location : 118.215.058 - 118.224.497
Synonym name
  • cell differentiation antigen CD3G (gp26), gamma polypeptide (see CD3@)
  • CD3G antigen, gamma polypeptide (TiT3 complex)
    • Synonym symbol(s) TAC12, T3G, CD3-GAMMA
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster, head to head
    text
  • see CD3@
  • head to head with CD3D
    • STRUCTURE 8.00 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure weak, lymphoid-specific TATA-less proximal promoter :
  • NFAT motifs in the proximal promoter positively or negatively regulating expression of CD3G by their differential binding of NFATc1 plus NF-kappaB p50 or NFATc2 containing complexes, respectively
    • MAPPING cloned Y linked N status provisional
    Physical map
    FXYD2 11q23,3 FXYD domain containing ion transport regulator 2 FXYD6 11q23.3 FXYD domain containing ion transport regulator 6 MSP 11q23 mosaic serine protease IL10RA 11q23.3 interleukin 10 receptor, alpha TMPRSS4 11q23.3 transmembrane protease, serine 4 SCN4B 11q23.3 sodium channel, voltage-gated, type IV, beta SCN2B 11q23 sodium channel, voltage-gated, type II, beta AMICA 11q23.3 adhesion molecule AMICA LOC196264 11q23.3 hypothetical protein LOC196264 EVA1 11q24 epithelial V-like antigen 1 CD3E 11q23.3 CD3E antigen, epsilon polypeptide (TiT3 complex) LOC390254 11 similar to carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5; N-acetylglucosamine 6-O-sulfotransferase; I-GLCNAC-6-ST CD3D 11q23.3 CD3D antigen, delta polypeptide (TiT3 complex) CD3G 11q23.3 CD3G antigen, gamma polypeptide (TiT3 complex) UBE4A 11q23.3 ubiquitination factor E4A (UFD2 homolog, yeast) ATP5L 3q27 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g MGC13053 11q23.3 hypothetical protein MGC13053 MLL 11q23 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) FLJ11783 11q23.3 hypothetical protein FLJ11783 LOC143941 11q23.3 similar to CDNA sequence BC021608 FLJ14399 11q23.3 hypothetical protein FLJ14399 FLJ21827 11q23.3 hypothetical protein FLJ21827 ARCN1 11q23.3 archain 1 KIAA0638 11q23.3 archain 1 TREH 11q23.3 trehalase (brush-border membrane glycoprotein) DDX6 11q23.3 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 LOC338656 11q23.3 similar to protein phosphatase 2A inhibitor-2 I-2PP2A BLR1 11q23.3 Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5) BCL9L 11q23.3 B-cell CLL/lymphoma 9-like UPK2 11q23 uroplakin 2 LOC283150 11q23.3 hypothetical protein LOC283150
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 822 - 182 - Krissensen
    - splicing - - - most T cells lineages Takase
    lacking the TM segments (exon 4)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
     thymus    
    Nervousbrain   moderately
    Respiratorylung    
    Urinarykidneytubuleconvoluted tubule  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an Ig extracellular domain
  • a cytoplasmic tail with the immunoreceptor tyrosine based activation motif (ITAM), isoform TAC12, 12kDa
  • three NFAT binding motifs (for NFATC1, NFATC2 and NFKB2)
  • highly evolutionarily conserved CXXC motif
  • a short extracellular stalk connecting its Ig-like domains to its transmembrane regions
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Cd3g
    homolog to C.elegans C02F5.5
    Homologene
    FAMILY immunoglobulin superfamily
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION
  • mediating signal transduction
  • the stalks of the CD3G, CD3E, CD3D, CD247 may be critical in transmitting part of the activation signal directly through the membrane
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • constituent of the CD3 (pre-T cell and T cell) antigen receptor complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CD3G
    related resource CD3Gbase: Mutation registry for autosomal recessive CD3gamma immunodeficiency
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS