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FLASH GENE
Symbol CD3D contributors: mct - updated : 01-09-2017
HGNC name CD3d molecule, delta (CD3-TCR complex)
HGNC id 1673
Corresponding disease
IMD19 Immunodeficiency 19
Location 11q23.3      Physical location : 118.209.788 - 118.213.459
Synonym name
  • cell differentiation antigen CD3D (gp20), delta polypeptide (see CD3@)
  • CD3D antigen, delta polypeptide (TiT3 complex)
  • T-cell receptor T3 delta chain
    • Synonym symbol(s) T3D, CD3-DELTA, CD3
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster, head to head
    text
  • see CD3@
  • head to head with CD3G
  • clustered with CD3epsilon, CD3gamma
    • STRUCTURE 5.16 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 771 18 171 - 1991 1831653
    4 - 639 - 127 - 1991 1831653
    lacking an exon in the coding region and the transmembrane domain
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
     thymus   highly
    Reproductivemale systemprostate  moderately
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an Ig extracellular domain
  • a cytoplasmic tail with the immunoreceptor tyrosine based activation motif (ITAM)
  • highly evolutionarily conserved CXXC motif
  • a short extracellular stalk connecting its Ig-like domains to its transmembrane regions
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Cd3d
    homolog to rattus Cd3d
    homolog to C.elegans K01A2.2
    Homologene
    FAMILY immunoglobulin superfamily
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text type I membrane protein
    basic FUNCTION
  • playing an essential role in promoting progression of early thymocytes toward double-positive stage
  • acting as a T-cell receptor
  • the stalks of the CD3G, CD3E, CD3D, CD247 may be critical in transmitting part of the activation signal directly through the membrane
  • CD3G and CD3D evolved from a common precursor gene to optimize peptide/MHC-triggered alphabeta TCR activation
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development , immunity/defense
    text
  • thymocyte development
    • PATHWAY
    metabolism hormone
    signaling signal transduction
    a component
  • constituent after pre T cell antigen reception complex
  • CD3D/CD28-inducible FAU/BCL2L14 complex may be involved in the regulation of T cell function and survival
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) IMD19
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in patients with aplastic anemia (AA)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS