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FLASH GENE

Symbol

CD320

contributors: mct - updated : 22-01-2009

HGNC name	CD320 molecule
HGNC id	16692

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	MMA methylmalonic aciduria 2
Location	19p13.2      Physical location : 8.367.010 - 8.373.240
Synonym name	8D6 antigen
	FDC-signaling molecule 8D6
	CD320 antigen
	transcobalamin receptor
Synonym symbol(s)	8D6A, 8D6, FDC-SM-8D6, TCBLR

DNA

TYPE	functioning gene
STRUCTURE	6.23 kb     5 Exon(s)

regulatory sequence	Promoter
	Binding site   transcription factor
text structure	RREB-1, C/EBP, and AP-1 may coordinately regulate CD320 expression

MAPPING

cloned

Y

linked

N

status

confirmed

Map	pter - D19S922 - D19S884 - CD320 - D19S916 - D19S865 - cen
Authors	UCSC (2009)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed CD320 5 - 1260 28.9 282 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining       Lymphoid         Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune dendritic cell Lymphoid/Immune T cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a signal sequence
	an extracellular region with two LDL-receptor class A domains
	a transmembrane domain
	a short cytoplasmic tail

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to rattus Cd320 (64.6 pc)
	homolog to murine Cd320 (60.6 pc)

Homologene

FAMILY

CATEGORY

antigen , signaling growth factor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum

basic FUNCTION	augmenting the proliferation of plasma cells precursors generated by IL-10 (Zhang 2001)
	putatively mediating follicular dendritic cells (FDC) in the germinal center stimulation of B cell growth

CELLULAR PROCESS	cell life, proliferation/growth
	cell organization/biogenesis

PHYSIOLOGICAL PROCESS

text	cell growth regulation

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other

the cell cycle associated expression of CD320 appears to be tightly regulated in synchrony with the proliferative phase of the cell cycle

ASSOCIATED DISORDERS

corresponding disease(s)

MMA

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     down-regulation of CD320 or blocking CBL uptake in cancer cells are strategies likely to arrest proliferation of cancer cells

ANIMAL & CELL MODELS