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FLASH GENE
Symbol CD300LF contributors: mct - updated : 14-11-2013
HGNC name CD300 antigen like family member F
HGNC id 29883
Location 17q25.1      Physical location : 72.690.452 - 72.709.108
Genatlas name CMRF-35H/IRp60 (inhibitory receptor protein of 60 kDa)/CD300a
Synonym name
  • CMRF-35-like molecule (CLM)-1
  • immune receptor expressed on myeloid cells 1
  • Synonym symbol(s) CD300f, CLM1, IREM1, IgSF13, NKIR, LMIR1
    DNA
    TYPE functioning gene
    STRUCTURE 18.72 kb     9 Exon(s)
    MAPPING cloned   linked   status
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1759 - 290 - 2003 14662855
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
    Nervousbrain     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Blood/Hematopoieticmyelocyte
    Nervousglia Homo sapiens
    Nervousneuron Homo sapiens
    Nervousoligodendrocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal signal peptide
  • a extracellular region with a single Ig V-like domain
  • a transmembrane region
  • and a cytoplasmic tail with two classical immunoreceptor tyrosine-based inhibitory motifs (ITIM)
  • HOMOLOGY
    interspecies homolog to murine Lmir1
    intraspecies homolog to CMRF35 and PIGR
    homolog to CD300LD
    Homologene
    FAMILY
    CATEGORY immunity/defense , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • ITIM-bearing receptor selectively expressed by dendritic cells and monocytes and may be potentially involved in the negative regulation of specific leukocyte population
  • inhibitory receptor, able to block osteoclastogenesis
  • inhibitory receptor of the Ig superfamily in myeloid cells
  • having inhibitory effects on mast cells and eosinophils
  • CD300A and CD300LF regulate the MYD88 and TICAM1-mediated TLR signalling pathways through differential activation of PTPN6 and PTPN11
  • is a novel regulator of eosinophil homeostasis and eosinophil accumulation is constantly governed by CD300LF, which negatively regulates eotaxin-induced eosinophil response
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal signal peptide
  • a extracellular region with a single Ig V-like domain
  • a transmembrane region
  • and a cytoplasmic tail with two classical immunoreceptor tyrosine-based inhibitory motifs (ITIM)
  • HOMOLOGY
    interspecies homolog to murine Lmir1
    intraspecies homolog to CMRF35 and PIGR
    homolog to CD300LD
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS