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FLASH GENE
Symbol CD300LD contributors: mct - updated : 12 -11-201
HGNC name CD300 molecule-like family member d
HGNC id 16848
Location 17q25.1      Physical location : 72.576.110 - 72.588.370
Synonym name
  • CMRF35-like molecule 4
  • immune receptor CD300d
  • Synonym symbol(s) UNQ9218, CD300D, CLM-4, CMRF35-A4, CMRF35A4
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text six members (CD300ACD300F) are clustered in a 450-kb region of human chromosome 17
    STRUCTURE 12.26 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 644 21.5 194 - 2012 2229100
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticgranulocyte Homo sapiens
    Blood/Hematopoieticmonocyte Homo sapiens
    cell lineage expressed in cells of myeloid lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • type I transmembrane receptor driven by a signal peptide 18 AA in length
  • a single extracellular Ig V-type domain
  • function of CD300d would be related to the regulation of the expression of other CD300 molecules and the composition of CD300 complexes on the cell surface
  • HOMOLOGY
    intraspecies homolog to CD300LF
    Homologene
    FAMILY CD300 family of immune receptors
    CATEGORY immunity/defense , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • retained intracellularly and more specifically within the ER
  • basic FUNCTION
  • function of CD300LD would be related to the regulation of the expression of other CD300 molecules and the composition of CD300 complexes on the cell surface
  • could play a role in the regulation and/or formation of CD300 complexes on the cell surface and consequently modulate the state of activation of myeloid cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms complexes with the CD300 family members, with the exception of CD300C
  • was able to form homocomplexes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CD300LD recruited FCER1G as efficiently as CD300C
  • able to recruit the adaptor DAP12 as efficiently as CD300C
  • is able to recruit the ITAM-bearing adaptor FCER1G, suggesting that if this receptor is able to reach the cell surface, it could deliver activating signals after engagement with a specific ligand similarly to CD300C
  • interacts with all members of the CD300 family with the exception of CD300C
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS