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FLASH GENE
Symbol CD300A contributors: mct - updated : 19-11-2013
HGNC name CD300a molecule
HGNC id 19319
Location 17q25.1      Physical location : 72.462.521 - 72.480.931
Synonym name
  • CD300A antigen
  • CMRF35H leukocyte immunoglobulin-like receptor
  • leukocyte membrane antigen
  • inhibitory receptor protein 60
  • NK inhibitory receptor
  • immunoglobulin superfamily member 12
    • Synonym symbol(s) IRC1, IRC2, IRp60, CMRF-35-H9, CRMF-35H, CMRF35H, IGSF12
    DNA
    TYPE functioning gene
    STRUCTURE 18.41 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    regionally located closely linked to CMRF35
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1911 - 299 - 2011 2204697
    - - 1554 - 186 - 2011 22046970
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
    Reproductivefemale systemovary   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Blood/Hematopoieticneutrophil
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two conserved N-linked glycosylation sites
  • a membrane proximal region with potential O-linked glycosylation sites
  • a proline-rich, relatively rigid hinge region
  • a transmembrane domain
  • a long cytoplasmic domain containing four potential immunoreceptor tyrosine-based inhibitory motifs (ITIMs)
  • two dileucine motifs, which are associated with endocytosis
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Cd300a
    intraspecies homolog to highly homologous with CD300C
    Homologene
    FAMILY
  • CD300 superfamily of immunoregulatory receptors
    • CATEGORY immunity/defense , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • contributed to the down-regulation of cytolytic activity in natural killer (NK) cells
  • is an inhibitory receptor expressed by human NK cells, but surprisingly, we show that not all NK clones are inhibited in a CD300A-dependent manner
  • CD300A and CD300C are indistinguishable on the surface of NK cells 1)
  • CD300A and CD300LF regulate the MYD88 and TICAM1-mediated TLR signalling pathways through differential activation of PTPN6 and PTPN11
  • CD300A/CD300C receptors are differentially expressed on human TH1 and TH17 cells and their ligation is capable of modulating TCR mediated signals
  • function of CD300A in tuning T and B cell responses
  • is a nonphagocytic phosphatidylserine receptor that regulates mast cell inflammatory responses to microbial infections
  • monocyte transendothelial migration is accompanied by an elevation of CD300A which serves an inhibitory function possibly required for termination of the actual transmigration
  • new hypoxia-inducible gene in primary human monocytes and monocyte-derived macrophages
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by by the hypoxic environment which represents a mechanism of regulation of monocyte/macrophage pro-inflammatory responses at pathologic sites
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to psoriasis
    Variant & Polymorphism SNP R111Q linked to psoriasis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS